Dr Naomi Wray Email
Telephone: +61 7 3845 3581
Facsimile: +61 7 3362 0101
Email: naomiWr@qimrberghofer.edu.au

Naomi Wray is an ARC Future Fellow and an NHMRC Honorary Senior Research Fellow. She is a statistical geneticist and leads the Psychiatric Genetics Laboratory at QIMR. Her early training was in quantitative genetics with application in livestock which provides a strong theoretical foundation for her research today. She holds a BSc in Animal Science from the University of Edinburgh (1984), an MS in Animal Breeding and Statistics from Cornell (1986) and a PhD in Quantitative Genetics from the University of Edinburgh (1989). Her career path (which includes 7 years off from research and 9 years working part-time) from livestock genetics through epidemiology of childhood leukaemia to psychiatric genetics has been underpinned at each stage by a strong interest in underlying theory and practical applications. She moved to Australia to join QIMR in 2005. She is currently involved in a number of international collaborations of genome-wide association studies (GWAS) for psychiatric disorders, including the International Schizophrenia Consortium, the Psychiatric GWAS Consortium for major depression and the Anxiety Genetics Study Team. Her current research also focuses on prediction of genetic risk to disease from genome-wide association data.


Publications
2015
 Oh G, Wang SC, Pal M, Chen ZF, Khare T, Tochigi M, Ng C, Yang YA, Kwan A, Kaminsky ZA, Mill J, Gunasinghe C, Tackett JL, Gottesman II, Willemsen G, de Geus EJ, Vink JM, Slagboom PE, Wray NR, Heath AC, Montgomery GW, Turecki G, Martin NG, Boomsma DI, McGuffin P, Kustra R, Petronis A: DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons. Biological Psychiatry 77(3):246-255, 2015 [PDF] [OSI] [PubMed] [More...]
 Mills NT, Wright MJ, Henders AK, Eyles DW, Baune BT, McGrath JJ, Byrne EM, Hansell NK, Birosova E, Scott JG, Martin NG, Montgomery GW, Wray NR, Vinkhuyzen AA: Heritability of Transforming Growth Factor-beta1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins. Twin Research and Human Genetics 18(1):28-35, 2015 [PDF] [N/OSI] [PubMed] [More...]
 Byrne EM, Psychiatric Genetics Consortium Major Depressive Disorder Working Group, Raheja UK, Stephens SH, Heath AC, Madden PA, Vaswani D, Nijjar GV, Ryan KA, Youssufi H, Gehrman PR, Shuldiner AR, Martin NG, Montgomery GW, Wray NR, Nelson EC, Mitchell BD, Postolache TT: Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder. The Journal of clinical psychiatry 76(2):128-134, 2015 [PDF] [PubMed] [More...]
 Marioni RE, Shah S, McRae AF, Chen BH, Colicino E, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, Feinberg AP, Fallin MD, Multhaup ML, Jaffe AE, Joehanes R, Schwartz J, Just AC, Lunetta KL, Murabito JM, Starr JM, Horvath S, Baccarelli AA, Levy D, Visscher PM, Wray NR, Deary IJ: DNA methylation age of blood predicts all-cause mortality in later life. Genome biology 16:25: 2015 [PDF] [N/OSI] [PubMed] [More...]
 Maier R, Moser G, Chen GB, Ripke S, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Coryell W, Potash JB, Scheftner WA, Shi J, Weissman MM, Hultman CM, Landén M, Levinson DF, Kendler KS, Smoller JW, Wray NR, Lee SH: Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder. American Journal of Human Genetics 96(2):283-294, 2015 [PDF] [OSI] [PubMed] [More...]
2014
 Nelson EC, Lynskey MT, Heath AC, Wray N, Agrawal A, Shand FL, Henders AK, Wallace L, Todorov AA, Schrage AJ, Madden PA, Degenhardt L, Martin NG, Montgomery GW: Association of OPRD1 polymorphisms with heroin dependence in a large case-control series. Addiction Biology 19(1):111-121, 2014 [PDF] [OSI] [PubMed] [More...]
 Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai PC, Collier DA, Murphy T, Dempster E, Mill J, UK Brain Expression Consortium, Battle A, Mostafavi S, Zhu X, Henders A, Byrne E, Wray NR, Martin NG, Spector TD, Wang J: Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. Genome biology 15(4):R56, 2014 [PDF] [OSI] [PubMed] [More...]
 Byrne EM, Heath AC, Madden PA, Pergadia ML, Hickie IB, Montgomery GW, Martin NG, Wray NR: Testing the role of circadian genes in conferring risk for psychiatric disorders. American journal of medical genetics. Part B, Neuropsychiatric genetics 165(3):254-260, 2014 [PDF] [PubMed] [More...]
 Chen GB, Lee SH, Brion MJ, Montgomery GW, Wray NR, Radford-Smith GL, Visscher PM, International IBD Genetics Consortium: Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data. Human Molecular Genetics 2014 [PDF unavailable] [PubMed] [More...]
 Power RA, Verweij KJ, Zuhair M, Montgomery GW, Henders AK, Heath AC, Madden PA, Medland SE, Wray NR, Martin NG: Genetic predisposition to schizophrenia associated with increased use of cannabis. Molecular Psychiatry 19(11):1201-1204, 2014 [PDF] [N/OSI] [PubMed] [More...]
 Byrne EM, Carrillo-Roa T, Penninx BW, Sallis HM, Viktorin A, Chapman B, Henders AK, Psychiatric Genomic Consortium Major Depressive Disorder Working Group, Pergadia ML, Heath AC, Madden PA, Sullivan PF, Boschloo L, van Grootheest G, McMahon G, Lawlor DA, Landén M, Lichtenstein P, Magnusson PK, Evans DM, Montgomery GW, Boomsma DI, Martin NG, Meltzer-Brody S, Wray NR: Applying polygenic risk scores to postpartum depression. Archives of women's mental health 17(6):519-528, 2014 [PDF] [N/OSI] [PubMed] [More...]
 Shah S, McRae AF, Marioni RE, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, Starr JM, Wray NR, Deary IJ, Visscher PM: Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Research 24(11):1725-1733, 2014 [PDF] [OSI] [PubMed] [More...]
2013
 Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G, Byrne EM, Blackwood DH, Boomsma DI, Cichon S, Heath AC, Holsboer F, Lucae S, Madden PA, Martin NG, McGuffin P, Muglia P, Noethen MM, Penninx BP, Pergadia ML, Potash JB, Rietschel M, Lin D, Müller-Myhsok B, Shi J, Steinberg S, Grabe HJ, Lichtenstein P, Magnusson P, Perlis RH, Preisig M, Smoller JW, Stefansson K, Uher R, Kutalik Z, Tansey KE, Teumer A, Viktorin A, Barnes MR, Bettecken T, Binder EB, Breuer R, Castro VM, Churchill SE, Coryell WH, Craddock N, Craig IW, Czamara D, De Geus EJ, Degenhardt F, Farmer AE, Fava M, Frank J, Gainer VS, Gallagher PJ, Gordon SD, Goryachev S, Gross M, Guipponi M, Henders AK, Herms S, Hickie IB, Hoefels S, Hoogendijk W, Hottenga JJ, Iosifescu DV, Ising M, Jones I, Jones L, Jung-Ying T, Knowles JA, Kohane IS, Kohli MA, Korszun A, Landen M, Lawson WB, Lewis G, Macintyre D, Maier W, Mattheisen M, McGrath PJ, McIntosh A, McLean A, Middeldorp CM, Middleton L, Montgomery GM, Murphy SN, Nauck M, Nolen WA, Nyholt DR, O'Donovan M, Oskarsson H, Pedersen N, Scheftner WA, Schulz A, Schulze TG, Shyn SI, Sigurdsson E, Slager SL, Smit JH, Stefansson H, Steffens M, Thorgeirsson T, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Völzke H, Weilburg JB, Willemsen G, Zitman FG, Neale B, Daly M, Levinson DF, Sullivan PF: A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry 18(4):497-511, 2013 [PDF] [OSI] [PubMed] [More...]
 Lee SH, Harold D, Nyholt DR, ANZGene Consortium, International Endogene Consortium, Genetic and Environmental Risk for Alzheimer's disease Consortium, Goddard ME, Zondervan KT, Williams J, Montgomery GW, Wray NR, Visscher PM: Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Human Molecular Genetics 22:832-841, 2013 [PDF unavailable] [PubMed] [More...]
 Byrne EM, Gehrman PR, Medland SE, Nyholt DR, Heath AC, Madden PA, Hickie IB, Van Duijn CM, Henders AK, Montgomery GW, Martin NG, Wray NR, Chronogen Consortium: A genome-wide association study of sleep habits and insomnia. American journal of medical genetics. Part B, Neuropsychiatric genetics 162(5):439-451, 2013 [PDF] [OSI] [PubMed] [More...]
 Byrne EM, Carrillo-Roa T, Henders AK, Bowdler L, McRae AF, Heath AC, Martin NG, Montgomery GW, Krause L, Wray NR: Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin. Translational Psychiatry 3:e269, 2013 [PDF] [OSI] [PubMed] [More...]
 Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisén L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kähler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landén M, Långström N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Mühleisen TW, Muir WJ, Müller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nöthen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnström K, Reif A, Ribasés M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zöllner S, Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Sullivan PF, Smoller JW, Kendler KS, Wray NR, International Inflammatory Bowel Disease Genetics Consortium (IIBDGC): Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45(9):984-994, 2013 [PDF] [OSI] [PubMed] [More...]
 Yang L, Neale BM, Liu L, Lee SH, Wray NR, Ji N, Li H, Qian Q, Wang D, Li J, Faraone SV, Wang Y, Psychiatric GWAS Consortium: ADHD Subgroup, Doyle AE, Reif A, Rothenberger A, Franke B, Sonuga-Barke EJ, Steinhausen HC, Buitelaar JK, Kuntsi J, Biederman J, Lesch KP, Kent L, Asherson P, Oades RD, Loo SK, Nelson SF, Faraone SV, Smalley SL, Banaschewski T, Arias Vasquez A, Todorov A, Charach A, Miranda A, Warnke A, Thapar A, Neale BM, Cormand B, Freitag C, Mick E, Mulas F, Middleton F, HakonarsonHakonarson H, Palmason H, Schäfer H, Roeyers H, McGough JJ, Romanos J, Crosbie J, Meyer J, Ramos-Quiroga JA, Sergeant J, Elia J, Langely K, Nisenbaum L, Romanos M, Daly MJ, Ribasés M, Gill M, O'Donovan M, Owen M, Casas M, Bayés M, Lambregts-Rommelse N, Williams N, Holmans P, Anney RJ, Ebstein RP, Schachar R, Medland SE, Ripke S, Walitza S, Nguyen TT, Renner TJ, Hu X: Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. American journal of medical genetics. Part B, Neuropsychiatric genetics 162B(5):419-430, 2013 [PDF unavailable] [PubMed] [More...]
 Robinson EB, Howrigan D, Yang J, Ripke S, Anttila V, Duncan LE, Jostins L, Barrett JC, Medland SE, MacArthur DG, Breen G, O'Donovan MC, Wray NR, Devlin B, Daly MJ, Visscher PM, Sullivan PF, Neale BM: Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'. Molecular Psychiatry 2013 [PDF unavailable] [PubMed] [More...]
2012
 Amin N, Byrne E, Johnson J, Chenevix-Trench G, Walter S, Nolte IM, kConFab Investigators, Vink JM, Rawal R, Mangino M, Teumer A, Keers JC, Verwoert G, Baumeister S, Biffar R, Petersmann A, Dahmen N, Doering A, Isaacs A, Broer L, Wray NR, Montgomery GW, Levy D, Psaty BM, Gudnason V, Chakravarti A, Sulem P, Gudbjartsson DF, Kiemeney LA, Thorsteinsdottir U, Stefansson K, van Rooij FJ, Aulchenko YS, Hottenga JJ, Rivadeneira FR, Hofman A, Uitterlinden AG, Hammond CJ, Shin SY, Ikram A, Witteman JC, Janssens AC, Snieder H, Tiemeier H, Wolfenbuttel BH, Oostra BA, Heath AC, Wichmann E, Spector TD, Grabe HJ, Boomsma DI, Martin NG, van Duijn CM: Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Molecular Psychiatry 17:1116-1129, 2012 [PDF] [OSI] [PubMed] [More...]
 Hansell NK, Wright MJ, Medland SE, Davenport TA, Wray NR, Martin NG, Hickie IB: Genetic co-morbidity between neuroticism, anxiety/depression and somatic distress in a population sample of adolescent and young adult twins. Psychological Medicine 42(6):1249-1260, 2012 [PDF] [N/OSI] [PubMed] [More...]
 Webb BT, Guo AY, Maher BS, Zhao Z, van den Oord EJ, Kendler KS, Riley BP, Gillespie NA, Prescott CA, Middeldorp CM, Willemsen G, de Geus EJ, Hottenga JJ, Boomsma DI, Slagboom EP, Wray NR, Montgomery GW, Martin NG, Wright MJ, Heath AC, Madden PA, Gelernter J, Knowles JA, Hamilton SP, Weissman MM, Fyer AJ, Huezo-Diaz P, McGuffin P, Farmer A, Craig IW, Lewis C, Sham P, Crowe RR, Flint J, Hettema JM: Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. European Journal of Human Genetics 20:1078-1084, 2012 [PDF] [OSI] [PubMed] [More...]
 Vinkhuyzen AA, Pedersen NL, Yang J, Lee SH, Magnusson PKE, Iacono WG, McGue M, Madden PAF, Heath AC, Luciano M, Payton A, Horan M, Ollier W, Pendleton N, Deary IJ, Montgomery GW, Martin NG, Visscher PM, Wray NR: Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. Translational Psychiatry 2:e102, 2012 [PDF] [OSI]
 Service SK, Verweij KJ, Lahti J, Congdon E, Ekelund J, Hintsanen M, Räikkönen K, Lehtimäki T, Kähönen M, Widen E, Taanila A, Veijola J, Heath AC, Madden PA, Montgomery GW, Sabatti C, Järvelin MR, Palotie A, Raitakari O, Viikari J, Martin NG, Eriksson JG, Keltikangas-Järvinen L, Wray NR, Freimer NB: A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. Translational Psychiatry 2:e116, 2012 [PDF] [N/OSI] [PubMed] [More...]
 Vinkhuyzen AA, Pedersen NL, Yang J, Lee SH, Magnusson PK, Iacono WG, McGue M, Madden PA, Heath AC, Luciano M, Payton A, Horan M, Ollier W, Pendleton N, Deary IJ, Montgomery GW, Martin NG, Visscher PM, Wray NR: Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. Translational Psychiatry 2:e102, 2012 [PDF unavailable] [PubMed] [More...]
 Tielbeek JJ, Medland SE, Benyamin B, Byrne EM, Heath AC, Madden PA, Martin NG, Wray NR, Verweij KJ: Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study. PLoS ONE 7(10):e45086, 2012 [PDF] [PubMed] [More...]
 Lee PH, Perlis RH, Jung JY, Byrne EM, Rueckert E, Siburian R, Haddad S, Mayerfeld CE, Heath AC, Pergadia ML, Madden PA, Boomsma DI, Penninx BW, Sklar P, Martin NG, Wray NR, Purcell SM, Smoller JW: Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder. Translational Psychiatry 2:e184, 2012 [PDF] [OSI] [PubMed] [More...]
61.Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR, Ripke S, MacIntyre DJ, McGhee KA, Maclean AW, Smit JH, Hottenga JJ, Willemsen G, Middeldorp CM, de Geus EJ, Lewis CM, McGuffin P, Hickie IB, van den Oord EJ, Liu JZ, Macgregor S, McEvoy BP, Byrne EM, Medland SE, Statham DJ, Henders AK, Heath AC, Montgomery GW, Martin NG, Boomsma DI, Madden PA, Sullivan PF: Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Molecular Psychiatry 17:36-48, 2012 [PDF] [OSI] [PubMed] [More...]
2011
 Lee SH, Wray NR, Goddard ME, Visscher PM: Estimating Missing Heritability for Disease from Genome-wide Association Studies. American Journal of Human Genetics 88(3):294-305, 2011 [PDF unavailable] [PubMed] [More...]
 Pergadia ML, Glowinski AL, Wray NR, Agrawal A, Saccone SF, Loukola A, Broms U, Korhonen T, Penninx BW, Grant JD, Nelson EC, Henders AK, Schrage AJ, Chou YL, Keskitalo-Vuokko K, Zhu Q, Gordon SD, Vink JM, de Geus EJ, Macgregor S, Liu JZ, Willemsen G, Medland SE, Boomsma DI, Montgomery GW, Rice JP, Goate AM, Heath AC, Kaprio J, Martin NG, Madden PA: A 3p26-3p25 Genetic Linkage Finding for DSM-IV Major Depression in Heavy Smoking Families. The American journal of psychiatry 168:848-852, 2011 [PDF] [OSI] [PubMed] [More...]
 Vinkhuyzen AA, Dumenil T, Ryan L, Gordon SD, Henders AK, Madden PA, Heath AC, Montgomery GW, Martin NG, Wray NR: Identification of tag haplotypes for 5HTTLPR for different genome-wide SNP platforms. Molecular Psychiatry 16:1073-1075, 2011 [PDF] [OSI] [PubMed] [More...]
 Visscher PM, Goddard ME, Derks EM, Wray NR: Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. Molecular Psychiatry 2011 [PDF unavailable] [PubMed] [More...]
 Stringer S, Wray NR, Kahn RS, Derks EM: Underestimated Effect Sizes in GWAS: Fundamental Limitations of Single SNP Analysis for Dichotomous Phenotypes. PLoS ONE 6(11):e27964, 2011 [PDF unavailable] [PubMed] [More...]
 Middeldorp CM, de Moor MH, McGrath LM, Gordon SD, Blackwood DH, Costa PT, Terracciano A, Krueger RF, de Geus EJ, Nyholt DR, Tanaka T, Esko T, Madden PA, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Ripke S, Sullivan PF, Realo A, Allik J, Heath AC, Pergadia ML, Agrawal A, Lin P, Grucza RA, Widen E, Cousminer DL, Eriksson JG, Palotie A, Barnett JH, Lee PH, Luciano M, Tenesa A, Davies G, Lopez LM, Hansell NK, Medland SE, Ferrucci L, Schlessinger D, Montgomery GW, Wright MJ, Aulchenko YS, Janssens AC, Oostra BA, Metspalu A, Abecasis GR, Deary IJ, Räikkönen K, Bierut LJ, Martin NG, Wray NR, van Duijn CM, Smoller JW, Penninx BW, Boomsma DI: The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Translational Psychiatry 1:e50, 2011 [PDF] [N/OSI] [PubMed] [More...]
64.Wray NR, Purcell SM, Visscher PM: Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results. PLoS biology 9(1):e1000579, 2011 [PDF unavailable] [PubMed] [More...]
63.Berk M, Johansson S, Wray NR, Williams L, Olsson C, Haavik J, Bjerkeset O: Glutamate cysteine ligase (GCL) and self reported depression: An association study from the HUNT. Journal of affective disorders 131:207-213, 2011 [PDF unavailable] [PubMed] [More...]
62.Ferreira MA, McRae AF, Medland SE, Nyholt DR, Gordon SD, Wright MJ, Henders AK, Madden PA, Visscher PM, Wray NR, Heath AC, Montgomery GW, Duffy DL, Martin NG: Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. European Journal of Human Genetics 19:458-464, 2011 [PDF] [PubMed] [More...]
58.Demirkan A, Penninx BW, Hek K, Wray NR, Amin N, Aulchenko YS, van Dyck R, de Geus EJ, Hofman A, Uitterlinden AG, Hottenga JJ, Nolen WA, Oostra BA, Sullivan PF, Willemsen G, Zitman FG, Tiemeier H, Janssens AC, Boomsma DI, van Duijn CM, Middeldorp CM: Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry 16:773-783, 2011 [PDF unavailable] [PubMed] [More...]
2010
60.Verweij KJ, Zietsch BP, Medland SE, Gordon SD, Benyamin B, Nyholt DR, McEvoy BP, Sullivan PF, Heath AC, Madden PA, Henders AK, Montgomery GW, Martin NG, Wray NR: A genome-wide association study of Cloninger's Temperament scales: Implications for the evolutionary genetics of personality. Biological Psychology 85:306-317, 2010 [PDF] [PubMed] [More...]
59.Liu JZ, McRae AF, Nyholt DR, Medland SE, Wray NR, Brown KM, AMFS Investigators, Hayward NK, Montgomery GW, Visscher PM, Martin NG, Macgregor S: A versatile gene-based test for genome-wide association studies. American Journal of Human Genetics 87(1):139-145, 2010 [PDF] [PubMed] [More...]
57.Moskvina V, Smith M, Ivanov D, Blackwood D, StClair D, Hultman C, Toncheva D, Gill M, Corvin A, O'Dushlaine C, Morris DW, Wray NR, Sullivan P, Pato C, Pato MT, Sklar P, Purcell S, Holmans P, O'Donovan MC, Owen MJ, Kirov G, International Schizophrenia Consortium: Genetic Differences between Five European Populations. Human Heredity 70(2):141-149, 2010 [PDF unavailable] [PubMed] [More...]
56.Coventry WL, James MR, Eaves LJ, Gordon SD, Gillespie NA, Ryan L, Heath AC, Montgomery GW, Martin NG, Wray NR: Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample. American journal of medical genetics. Part B, Neuropsychiatric genetics 153B(3):757-765, 2010 [PDF] [PubMed] [More...]
55.Wray NR, Visscher PM: Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophrenia bulletin 36(1):14-23, 2010 [PDF] [PubMed] [More...]
54.Wray NR, Goddard ME: Multi-locus models of genetic risk of disease. Genome medicine 2(2):10-10, 2010 [PDF] [PubMed] [More...]
53.Wray NR, Yang J, Goddard ME, Visscher PM: The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genetics 6(2):e1000864, 2010 [PDF] [PubMed] [More...]
52.Yang J, Wray NR, Visscher PM: Comparing apples and oranges: equating the power of case-control and quantitative trait association studies. Genetic Epidemiology 34(3):254-257, 2010 [PDF unavailable] [PubMed] [More...]
51.Yang J, Visscher PM, Wray NR: Sporadic cases are the norm for complex disease. European Journal of Human Genetics 18:1039-1043, 2010 [PDF unavailable] [PubMed] [More...]
2009
50.Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Farmer A, Fava M, Gordon SD, He Q, Heath AC, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hu Y, Kohli M, Lin D, Lucae S, Macintyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery GW, Muir WJ, Nolen WA, Nöthen MM, Perlis RH, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit AB, Smoller JW, Tzeng JY, van Dyck R, Verhage M, Zitman FG, Martin NG, Wray NR, Boomsma DI, Penninx BW: Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Molecular Psychiatry 14:359-375, 2009 [PDF] [PubMed] [More...]
49.Wray NR, James MR, Gordon SD, Dumenil T, Ryan L, Coventry WL, Statham DJ, Pergadia ML, Madden PA, Heath AC, Montgomery GW, Martin NG: Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures. Biological Psychiatry 66:468-476, 2009 [PDF] [PubMed] [More...]
48.Mosing MA, Gordon SD, Medland SE, Statham DJ, Nelson EC, Heath AC, Martin NG, Wray NR: Genetic and environmental influences on the co-morbidity between depression, panic disorder, agoraphobia, and social phobia: a twin study. Depression and anxiety 26(11):1004-1011, 2009 [PDF] [PubMed] [More...]
47.Coventry WL, Medland SE, Wray NR, Thorsteinsson EB, Heath AC, Byrne B: Phenotypic and discordant-monozygotic analyses of stress and perceived social support as antecedents to or sequelae of risk for depression. Twin Research and Human Genetics 12(5):469-488, 2009 [PDF unavailable] [PubMed] [More...]
46.: Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009 [PDF] [PubMed] [More...]
45.Evans DM, Visscher PM, Wray NR: Harnessing the Information Contained Within Genome-wide Association Studies to Improve Individual Prediction of Complex Disease Risk. Human Molecular Genetics 18:3525-3531, 2009 [PDF unavailable] [PubMed] [More...]
44.Middeldorp CM, Sullivan PF, Wray NR, Hottenga JJ, de Geus EJ, van den Berg M, Montgomery GW, Coventry WL, Statham DJ, Andrews G, Slagboom PE, Boomsma DI, Martin NG: Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(3):352-358, 2009 [PDF] [PubMed] [More...]
2008
43.Wray NR, James MR, Handoko HY, Dumenil T, Lind PA, Montgomery GW, Martin NG: Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression. American journal of medical genetics. Part B, Neuropsychiatric genetics 18(5):219-225, 2008 [PDF] [PubMed] [More...]
42.Wray NR, Middeldorp CM, Birley AJ, Gordon SD, Sullivan PF, Visscher PM, Nyholt DR, Willemsen G, de Geus EJ, Slagboom PE, Montgomery GW, Martin NG, Boomsma DI: Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. Archives of General Psychiatry 65(6):649-658, 2008 [PDF] [PubMed] [More...]
41.Wray NR, Goddard ME, Visscher PM: Prediction of individual genetic risk of complex disease. Current opinion in genetics & development 18:257-263, 2008 [PDF] [PubMed] [More...]
40.Wray NR, Coventry WL, James MR, Montgomery GW, Eaves LJ, Martin NG: Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory. Novartis Foundation symposium 293:48-59, 2008 [PDF] [PubMed] [More...]
39.Wray NR, James MR, Dumenil T, Handoko HY, Lind PA, Montgomery GW, Martin NG: Association study of candidate variants of COMT with neuroticism, anxiety and depression. American journal of medical genetics. Part B, Neuropsychiatric genetics 147B:1314-1318, 2008 [PDF] [PubMed] [More...]
38.Wade TD, Tiggemann M, Bulik CM, Fairburn CG, Wray NR, Martin NG: Shared temperament risk factors for anorexia nervosa: a twin study. Psychosomatic Medicine 70(2):239-244, 2008 [PDF] [PubMed] [More...]
37.Shifman S, Bhomra A, Smiley S, Wray NR, James MR, Martin NG, Hettema JM, An SS, Neale MC, van den Oord EJ, Kendler KS, Chen X, Boomsma DI, Middeldorp CM, Hottenga JJ, Slagboom PE, Flint J: A whole genome association study of Neuroticism using DNA pooling. Molecular Psychiatry 13(3):302-312, 2008 [PDF] [PubMed] [More...]
2007
36.Wray NR, Goddard ME, Visscher PM: Prediction of individual genetic risk to disease from genome-wide association studies. Genome Research 17(10):1520-1528, 2007 [PDF] [PubMed] [More...]
35.Christoforou A, Le Hellard S, Thomson PA, Morris SW, Tenesa A, Pickard BS, Wray NR, Muir WJ, Blackwood DH, Porteous DJ, Evans KL: Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. Molecular Psychiatry 12(11):1011-1025, 2007 [PDF] [PubMed] [More...]
34.Wray NR, Birley AJ, Sullivan PF, Visscher PM, Martin NG: Genetic and phenotypic stability of measures of neuroticism over 22 years. Twin Research and Human Genetics 10(5):695-702, 2007 [PDF] [PubMed] [More...]
33.Tomlinson VA, Newbery HJ, Bergmann JH, Boyd J, Scott D, Wray NR, Sellar GC, Gabra H, Graham A, Williams AR, Abbott CM: Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus. British Journal of Cancer 96(10):1613-1620, 2007 [PDF] [PubMed] [More...]
32.Le Hellard S, Lee AJ, Underwood S, Thomson PA, Morris SW, Torrance HS, Anderson SM, Adams RR, Navarro P, Christoforou A, Houlihan LM, Detera-Wadleigh S, Owen MJ, Asherson P, Muir WI, Blackwood DHR, Wray NR, Porteous DI, Evans KL: Haplotype Analysis and a Novel Allele-Sharing Method Refines a Chromosome 4p Locus Linked to Bipolar Affective Disorder. Biological Psychiatry 61(6):797-805, 2007 [PDF]
31.Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, Montgomery GW, Birley AJ, Braun A, Martin NG: Anxiety and Comorbid Measures Associated With PLXNA2. Archives of General Psychiatry 64(3):318-326, 2007 [PDF] [PubMed] [More...]
30.Wray NR, Visscher PM: Mapping common disease genes. In: Wright A,Hastie N, eds. Genes and common diseases - genetics in modern medicine: Cambridge University Press, 2007. [PDF unavailable]
2006
29.Middeldorp CM, Wray NR, Andrews G, Martin NG, Boomsma DI: Sex differences in symptoms of depression in unrelated individuals and opposite-sex twin and sibling pairs. Twin Research and Human Genetics 9(5):632-636, 2006 [PDF] [PubMed] [More...]
28.Sullivan PF, Montgomery GW, Hottenga JJ, Wray NR, Boomsma DI, Martin NG: Empirical evaluation of the genetic similarity of samples from twin registries in Australia and The Netherlands using 359 STRP markers. Twin Research and Human Genetics 9(4):600-602, 2006 [PDF] [PubMed] [More...]
27.Underwood SL, Christoforou A, Thomson PA, Wray NR, Tenesa A, Whittaker J, Adams RA, Le Hellard S, Morris SW, Blackwood DHR, Muir WJ, Porteous DJ, Evans KL: Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia. Molecular Psychiatry 11(4):384-394, 2006 [PDF]
2005
26.Wray NR: Allele Frequencies and the r2 Measure of Linkage Disequilibrium: Impact on Design and Interpretation of Association Studies. Twin Research and Human Genetics 8(2):87-94, 2005 [PDF]
25.Tomlinson VAL, Newbery HJ, Wray NR, Jackson J, Larionov A, Miller WR, Dixon JM, Abbott CM: Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours. BMC Cancer 5: 2005 [PDF]
24.Thomson PA, Wray NR, Millar JK, Evans KL, Le Hellard S, Condie A, Muir WJ, Blackwood DHR, Porteous DJ: Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. Molecular Psychiatry 10(7):657-668, 2005 [PDF]
23.Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DHR, Porteous DJ: Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. Molecular Psychiatry 10(5):470-478, 2005 [PDF]
2004
22.Visscher PM, Wray NR: Conventional Multipoint Nonparametric Linkage Analysis is not Necessarily Inherently Biased. American Journal of Human Genetics 75(4):718-720, 2004 [PDF]
2003
21.Porteous DJ, Evans KL, Millar JK, Pickard BS, Thomson PA, James R, Macgregor S, Wray NR, Visscher PM, Muir WJ, Blackwood DHR: Genetics of Schizophrenia and Bipolar Affective Disorder: Strategies to Identify Candidate Genes. [PDF]
20.Millar JK, Thomson PA, Wray NR, Muir WJ, Blackwood DHR, Porteous DJ: Response to Amar J. Klar: The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders. Genetics 163(2):833-835, 2003 [PDF]
1999
19.Alexander FE, Boyle P, Carli PM, Coebergh JW, Ekbom A, Levi F, McKinney PA, McWhirter W, Michaelis J, Peris-Bonet R, Petridou E, Pompe-Kirn V, Plesko I, Pukkala E, Rahu M, Stiller CA, Storm H, Terracini B, Vatten L, Wray NR: Population density and childhood leukaemia: Results of the EUROCLUS study. European Journal of Cancer 35:439-444, 1999 [PDF]
18.Wray NR, Alexander FE, Muirhead CR, Pukkala E, Schmidtmann I, Stiller CA: A comparison of some simple methods to identify geographical areas with excess incidence of a rare disease such as childhood leukaemia. Statistics in Medicine 18(12):1501-1516, 1999 [PDF]
1998
17.Alexander FE, Boyle P, Carli PM, Coebergh JW, Draper GJ, Ekbom A, Levi F, McKinney PA, McWhirter W, Michaelis J, Peris-Bonet R, Petridou E, Pompe-Kirn V, Plisko I, Pukkala E, Rahu M, Storm H, Terracini B, Vatten L, Wray NR: Spatial clustering of childhood leukaemia: summary results from the EUROCLUS project. British Journal of Cancer 77:818-824, 1998 [PDF unavailable]
16.Alexander FE, Boyle P, Carli PM, Coebergh JW, Draper GJ, Ekbom A, Levi F, McKinney PA, McWhirter W, Michaelis J, Peris-Bonet R, Petridou E, Pompe-Kirn V, Plisko I, Pukkala E, Rahu M, Storm H, Terracini B, Vatten L, Wray NR: Spatial temporal patterns in childhood leukaemia: further evidence for an infectious origin. British Journal of Cancer 77:812-817, 1998 [PDF unavailable]
1997
15.Petridou E, Alexander FE, Trichopoulos D, Revinthi K, Dessypris N, Wray NR, Haidas S, Koliouskas D, Kosmidis H, Piperopoulou F, Tzortzatou F: Aggregation of childhood leukemia in geographic areas of Greece. Cancer Causes and Control 8:239-245, 1997 [PDF]
14.Crump RE, Wray NR, Thompson R, Simm G: Assigning pedigree beef performance records to contemporary groups taking account of within-herd calving patterns. Animal Science 65:193-198, 1997 [PDF unavailable]
1996
13.Brash LD, Wray NR, Goddard ME: Use of MOET in Merino breeding programmes: A practical and economic appraisal. Animal Science 62:241-254, 1996 [PDF]
1994
12.Wray NR, Goddard ME: Increasing Long-Term Response to Selection. Genetics Selection Evolution 26(5):431-451, 1994 [PDF]
11.Wray NR, Goddard ME: Moet Breeding Schemes for Wool Sheep .1. Design Alternatives. Animal Production 59:71-86, 1994 [PDF unavailable]
10.Wray NR, Goddard ME: Moet Breeding Schemes for Wool Sheep .2. Selection for Adult Fleece Traits. Animal Production 59:87-98, 1994 [PDF unavailable]
9.Thompson R, Wray NR, Crump RE: Calculation of Prediction Error Variances Using Sparse-Matrix Methods. Journal of Animal Breeding and Genetics: Zeitschrift Fur Tierzuchtung Und Zuchtungsbiologie 111(2):102-109, 1994 [PDF]
8.Wray NR, Woolliams JA, Thompson R: Prediction of Rates of Inbreeding in Populations Undergoing Index Selection. Theoretical and Applied Genetics 87(7):878-892, 1994 [PDF unavailable]
1993
7.Woolliams JA, Wray NR, Thompson R: Prediction of Long-Term Contributions and Inbreeding in Populations Undergoing Mass Selection. Genetical Research 62(3):231-242, 1993 [PDF unavailable]
6.Villanueva B, Wray NR, Thompson R: Prediction of Asymptotic Rates of Response from Selection on Multiple Traits Using Univariate and Multivariate Best Linear Unbiased Predictors. Animal Production 57:1-13, 1993 [PDF unavailable]
1990
5.Wray NR, Thompson R: Prediction of Rates of Inbreeding in Selected Populations. Genetical Research 55(1):41-54, 1990 [PDF]
4.Wray NR: Accounting for Mutation Effects in the Additive Genetic Variance Covariance-Matrix and Its Inverse. Biometrics 46(1):177-186, 1990 [PDF]
3.Wray NR, Woolliams JA, Thompson R: Methods for Predicting Rates of Inbreeding in Selected Populations. Theoretical and Applied Genetics 80(4):503-512, 1990 [PDF]
1989
2.Wray NR, Hill WG: Asymptotic Rates of Response from Index Selection. Animal Production 49:217-227, 1989 [PDF]
1987
1.Wray NR, Quaas RL, Pollak EJ: Analysis of Gestation Length in American Simmental Cattle. Journal of Animal Science 65(4):970-974, 1987 [PDF]