Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23077488
TITLE
Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.
ABSTRACT
Crime poses a major burden for society. The heterogeneous nature of criminal behavior makes it difficult to unravel its causes. Relatively little research has been conducted on the genetic influences of criminal behavior. The few twin and adoption studies that have been undertaken suggest that about half of the variance in antisocial behavior can be explained by genetic factors. In order to identify the specific common genetic variants underlying this behavior, we conduct the first genome-wide association study (GWAS) on adult antisocial behavior. Our sample comprised a community sample of 4816 individuals who had completed a self-report questionnaire. No genetic polymorphisms reached genome-wide significance for association with adult antisocial behavior. In addition, none of the traditional candidate genes can be confirmed in our study. While not genome-wide significant, the gene with the strongest association (p-value = 8.7×10(-5)) was DYRK1A, a gene previously related to abnormal brain development and mental retardation. Future studies should use larger, more homogeneous samples to disentangle the etiology of antisocial behavior. Biosocial criminological research allows a more empirically grounded understanding of criminal behavior, which could ultimately inform and improve current treatment strategies.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/03/05
accepted 2012/08/17
entrez 2012/10/19 06:00
pubmed 2012/10/19 06:00
medline 2013/03/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Tielbeek JJ Tielbeek Jorim J JJ Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. tielbeekjorim@gmail.com
Medland SE Medland Sarah E SE
Benyamin B Benyamin Beben B
Byrne EM Byrne Enda M EM
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Martin NG Martin Nicholas G NG
Wray NR Wray Naomi R NR
Verweij KJ Verweij Karin J H KJ
INVESTIGATORS
JOURNAL
VOLUME: 7
ISSUE: 10
TITLE: PloS one
ISOABBREVIATION: PLoS One
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1932-6203
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS One
COUNTRY: United States
ISSNLINKING: 1932-6203
NLMUNIQUEID: 101285081
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Trends Cogn Sci. 2006 Sep;10(9):419-23 16901745
Cites Adv Genet. 2005;55:41-104 16291212
Cites Am J Med Genet B Neuropsychiatr Genet. 2008 Mar 5;147B(2):228-32 18023041
Cites J Neurosci. 2008 May 7;28(19):5099-104 18463263
Cites Nature. 2008 Nov 6;456(7218):18-21 18987709
Cites J Am Acad Child Adolesc Psychiatry. 2009 Jan;48(1):42-50 19034046
Cites Clin Psychol Rev. 2009 Mar;29(2):163-78 19193479
Cites Psychiatr Genet. 2009 Dec;19(6):312-9 19829167
Cites Am J Hum Genet. 2009 Nov;85(5):750-5 19896111
Cites Compr Psychiatry. 2010 Mar-Apr;51(2):130-4 20152292
Cites Am J Hum Genet. 2010 Feb 12;86(2):113-25 20060087
Cites J Soc Psychol. 2010 Mar-Apr;150(2):160-80 20397592
Cites Mol Psychiatry. 2010 Jun;15(6):647-56 18957941
Cites Nat Genet. 2010 Jul;42(7):565-9 20562875
Cites Am J Hum Genet. 2010 Jul 9;87(1):139-45 20598278
Cites Genet Epidemiol. 2010 Dec;34(8):816-34 21058334
Cites Twin Res Hum Genet. 2010 Dec;13(6):517-24 21142928
Cites Psychiatry Res. 2011 Feb 28;185(3):382-6 20850185
Cites Compr Psychiatry. 2011 Mar-Apr;52(2):188-94 21295226
Cites J Abnorm Child Psychol. 2011 Apr;39(3):321-32 21152968
Cites Mol Psychiatry. 2011 May;16(5):516-32 20351714
Cites Br J Psychiatry. 2011 Jun;198(6):457-63 21628708
Cites Mol Psychiatry. 2011 Aug;16(8):800-8 20585324
Cites Behav Genet. 2011 Sep;41(5):629-40 21431322
Cites Psychiatr Genet. 2011 Oct;21(5):240-8 21399568
Cites Cell. 2011 Sep 30;147(1):57-69 21962507
Cites Am J Psychiatry. 2011 Oct;168(10):1041-9 21890791
Cites Annu Rev Psychol. 2012;63:571-91 19575613
Cites Int J Law Psychiatry. 2012 Jan-Feb;35(1):19-26 22154472
Cites Addict Biol. 2012 May;17(3):687-90 21507154
Cites Psychol Sci. 2012;23(11):1314-23 23012269
Cites Nat Genet. 2002 Jan;30(1):97-101 11731797
Cites Nat Rev Genet. 2002 Nov;3(11):872-82 12415317
Cites Clin Psychol Rev. 2002 Nov;22(8):1179-207 12436810
Cites Bioinformatics. 2003 Jan;19(1):149-50 12499305
Cites Brain Res. 2003 Feb 28;964(2):250-63 12576186
Cites Behav Genet. 2003 Sep;33(5):575-89 14574134
Cites J Neural Transm Suppl. 2003;(67):129-37 15068245
Cites Twin Res. 2004 Apr;7(2):162-75 15169601
Cites Arch Gen Psychiatry. 2004 Jul;61(7):738-44 15237086
Cites Neuropsychopharmacology. 2004 Aug;29(8):1498-505 15150530
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites J Pers Soc Psychol. 1997 Jan;72(1):207-17 9008382
Cites Psychol Bull. 2005 Jul;131(4):533-54 16060801
Cites Nat Genet. 2005 Nov;37(11):1243-6 16228001
Cites EMBO Rep. 2007 Jul;8 Spec No:S52-6 17726445
GRANTS
GRANTID AGENCY COUNTRY
AA13320 NIAAA NIH HHS United States
DA12854 NIDA NIH HHS United States
AA013326 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
AA014041 NIAAA NIH HHS United States
AA013321 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA014041 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
R56 DA012854 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Antisocial Personality Disorder genetics
Genome-Wide Association Study genetics
Humans genetics
Polymorphism, Genetic genetics
Surveys and Questionnaires genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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