Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18158375
TITLE
Shared temperament risk factors for anorexia nervosa: a twin study.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
To answer two questions about the nature of the relationship between anorexia nervosa (AN) and dimensional temperament traits: Which traits are comorbid with AN? Which traits share transmitted liabilities with AN?
METHODS NlmCategory: METHODS
A community sample of 1002 same-gender female twins was selected with respect to participation in two earlier waves of data collection. Measures of eating disorder diagnoses and features were ascertained through interview and continuous measures of temperament were ascertained from self-report measures.
RESULTS NlmCategory: RESULTS
Four temperaments were comorbid with AN, namely, higher levels of perfectionism (concern over mistakes, personal standards, doubt about actions), and higher need for organization. Comparison between the female co-twins of AN probands and controls (who had never had an eating disorder) showed that the former group reported higher levels of personal standards, organization, and reward dependence. The association between personal standards and reward dependence remained when controlling for the temperament of the proband or control in monozygotic twins.
CONCLUSIONS NlmCategory: CONCLUSIONS
The evidence overall supports the suggestion that AN may represent the expression of a common underlying familial liability to a temperament style that reflects a striving for perfectionism, a need for order, and a sensitivity to praise and reward. The nature of the shared risk factors is likely to be, in part, genetic.
DATE PUBLISHED
2008 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2007/12/24
pubmed 2007/12/26 09:00
medline 2008/04/30 09:00
entrez 2007/12/26 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wade TD Wade Tracey D TD School of Psychology, Flinders University, P.O. Box 2100, Adelaide, SA 5001, Australia. tracey.wade@flinders.edu.au
Tiggemann M Tiggemann Marika M
Bulik CM Bulik Cynthia M CM
Fairburn CG Fairburn Christopher G CG
Wray NR Wray Naomi R NR
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 70
ISSUE: 2
TITLE: Psychosomatic medicine
ISOABBREVIATION: Psychosom Med
YEAR: 2008
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1534-7796
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychosom Med
COUNTRY: United States
ISSNLINKING: 0033-3174
NLMUNIQUEID: 0376505
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
046386 Wellcome Trust United Kingdom
046386 Wellcome Trust United Kingdom
079113 Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Anorexia Nervosa psychology
Australia epidemiology
Case-Control Studies epidemiology
Comorbidity epidemiology
Diseases in Twins psychology
Female psychology
Humans psychology
Linear Models psychology
Logistic Models psychology
Personality psychology
Risk Factors psychology
Temperament psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's