|
|
| PMID |
|
|
| TITLE |
|
| DNA methylation age of blood predicts all-cause mortality in later life. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biological age. |
| RESULTS |
NlmCategory: RESULTS |
| Here we test whether differences between people's chronological ages and estimated ages, DNA methylation age, predict all-cause mortality in later life. The difference between DNA methylation age and chronological age (Δage) was calculated in four longitudinal cohorts of older people. Meta-analysis of proportional hazards models from the four cohorts was used to determine the association between Δage and mortality. A 5-year higher Δage is associated with a 21% higher mortality risk, adjusting for age and sex. After further adjustments for childhood IQ, education, social class, hypertension, diabetes, cardiovascular disease, and APOE e4 status, there is a 16% increased mortality risk for those with a 5-year higher Δage. A pedigree-based heritability analysis of Δage was conducted in a separate cohort. The heritability of Δage was 0.43. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| DNA methylation-derived measures of accelerated aging are heritable traits that predict mortality independently of health status, lifestyle factors, and known genetic factors. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2014/07/10 |
| accepted |
2015/01/12 |
| aheadofprint |
2015/01/30 |
| entrez |
2015/01/31 06:00 |
| pubmed |
2015/01/31 06:00 |
| medline |
2015/12/15 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Marioni RE |
|
Marioni |
Riccardo E |
RE |
|
Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia. riccardo.marioni@ed.ac.uk. |
| Shah S |
|
Shah |
Sonia |
S |
|
University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, 4072, QLD, Australia. s.shah1@uq.edu.au. |
| McRae AF |
|
McRae |
Allan F |
AF |
|
University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, 4072, QLD, Australia. a.mcrae@uq.edu.au. |
| Chen BH |
|
Chen |
Brian H |
BH |
|
Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, 01702, USA. brian.chen@nih.gov. |
| Colicino E |
|
Colicino |
Elena |
E |
|
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. ecolicin@hsph.harvard.edu. |
| Harris SE |
|
Harris |
Sarah E |
SE |
|
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. Sarah.Harris@igmm.ed.ac.uk. |
| Gibson J |
|
Gibson |
Jude |
J |
|
Wellcome Trust Clinical Research Facility, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. jgibson6@staffmail.ed.ac.uk. |
| Henders AK |
|
Henders |
Anjali K |
AK |
|
Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, 4029, QLD, Australia. Anjali.Henders@qimrberghofer.edu.au. |
| Redmond P |
|
Redmond |
Paul |
P |
|
Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. paul.redmond@ed.ac.uk. |
| Cox SR |
|
Cox |
Simon R |
SR |
|
Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. simon.cox@ed.ac.uk. |
| Pattie A |
|
Pattie |
Alison |
A |
|
Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. Alison.Pattie@ed.ac.uk. |
| Corley J |
|
Corley |
Janie |
J |
|
Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. janie.corley@ed.ac.uk. |
| Murphy L |
|
Murphy |
Lee |
L |
|
Wellcome Trust Clinical Research Facility, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. Lee.Murphy@ed.ac.uk. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, 4029, QLD, Australia. Nick.Martin@qimrberghofer.edu.au. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, 4029, QLD, Australia. Grant.Montgomery@qimrberghofer.edu.au. |
| Feinberg AP |
|
Feinberg |
Andrew P |
AP |
|
Departments of Medicine, Molecular Biology/Genetics, Oncology, and Biostatistics, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. afeinberg@jhu.edu. |
| Fallin MD |
|
Fallin |
M Daniele |
MD |
|
Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA. dfallin@jhu.edu. |
| Multhaup ML |
|
Multhaup |
Michael L |
ML |
|
Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. mmulthaup@gmail.com. |
| Jaffe AE |
|
Jaffe |
Andrew E |
AE |
|
Lieber Institute for Brain Development, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org. |
| Joehanes R |
|
Joehanes |
Roby |
R |
|
Hebrew Senior Life, Boston, MA, 02131, USA. robyjoehanes@hsl.harvard.edu. |
| Schwartz J |
|
Schwartz |
Joel |
J |
|
Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA. jschwrtz@hsph.harvard.edu. |
| Just AC |
|
Just |
Allan C |
AC |
|
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. acjust@hsph.harvard.edu. |
| Lunetta KL |
|
Lunetta |
Kathryn L |
KL |
|
Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA. klunetta@bu.edu. |
| Murabito JM |
|
Murabito |
Joanne M |
JM |
|
Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA. murabito@bu.edu. |
| Starr JM |
|
Starr |
John M |
JM |
|
Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK. jstarr@staffmail.ed.ac.uk. |
| Horvath S |
|
Horvath |
Steve |
S |
|
Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA, 90095, USA. shorvath@mednet.ucla.edu. |
| Baccarelli AA |
|
Baccarelli |
Andrea A |
AA |
|
Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA. abaccare@hsph.harvard.edu. |
| Levy D |
|
Levy |
Daniel |
D |
|
Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, 01702, USA. levyd@nhlbi.nih.gov. |
| Visscher PM |
|
Visscher |
Peter M |
PM |
|
University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, 4072, QLD, Australia. peter.visscher@uq.edu.au. |
| Wray NR |
|
Wray |
Naomi R |
NR |
|
Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia. naomi.wray@uq.edu.au. |
| Deary IJ |
|
Deary |
Ian J |
IJ |
|
Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. i.deary@ed.ac.uk. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 16 |
| ISSUE: |
| TITLE: Genome biology |
| ISOABBREVIATION: Genome Biol. |
| YEAR: 2015 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1474-760X |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Genome Biol |
| COUNTRY: England |
| ISSNLINKING: 1474-7596 |
| NLMUNIQUEID: 100960660 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| CZB/4/505 |
Chief Scientist Office |
United Kingdom |
| ETM/55 |
Chief Scientist Office |
United Kingdom |
| G0700704 |
Medical Research Council |
United Kingdom |
| MR/K026992/1 |
Medical Research Council |
United Kingdom |
| R01 ES020268 |
NIEHS NIH HHS |
United States |
| R01AG029451 |
NIA NIH HHS |
United States |
| R01ES015172 |
NIEHS NIH HHS |
United States |
| R01ES021733 |
NIEHS NIH HHS |
United States |
|
Biotechnology and Biological Sciences Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Aged |
|
| Aging |
genetics |
| Blood |
metabolism |
| Cause of Death |
metabolism |
| Cohort Studies |
metabolism |
| DNA Methylation |
genetics |
| Demography |
genetics |
| Female |
genetics |
| Humans |
genetics |
| Inheritance Patterns |
genetics |
| Leukocyte Count |
genetics |
| Male |
genetics |
| Mortality |
genetics |
| Risk Factors |
genetics |
| Survival Analysis |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| PMC4350614 |
NLM |
|
|
