Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18615541
TITLE
Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression.
ABSTRACT
It is well established that major depressive disorder (MDD) is partly heritable. We present a genome-wide linkage study aiming to find regions on the genome that influence the vulnerability for MDD. Our sample consists of 110 Australian and 23 Dutch pedigrees with two or more siblings affected with MDD (total N = 278). Linkage analysis was carried out in MERLIN. Three regions showed suggestive linkage signals. The highest LOD-score of 2.1 was found on chromosome 17 at 52.6 cM along with LOD scores of 1.9 and 1.7 on chromosome 8 at 2.7 cM and chromosome 2 at 90.6 cM, respectively. The result on chromosome 8 seems most promising as two previous studies also found linkage in this region, once suggestive and once significant. The linkage peak on chromosome 17 harbors the serotonin transporter gene. In the Australian and Dutch sample, the serotonin transporter length polymorphism did not show evidence for association, thus other genes in this region or other polymorphisms in the serotonin transporter gene might be associated with MDD. Further replication is needed to establish the relevance of our linkage finding on chromosome 2.
(c) 2008 Wiley-Liss, Inc.
DATE PUBLISHED
2009 Apr 5
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/07/11 09:00
medline 2009/05/20 09:00
entrez 2008/07/11 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Middeldorp CM Middeldorp Christel M CM Department of Biological Psychology, VU University, Amsterdam, The Netherlands. cm.middeldorp@psy.vu.nl
Sullivan PF Sullivan Patrick F PF
Wray NR Wray Naomi R NR
Hottenga JJ Hottenga Jouke-Jan JJ
de Geus EJ de Geus Eco J C EJ
van den Berg M van den Berg Mireille M
Montgomery GW Montgomery Grant W GW
Coventry WL Coventry Will L WL
Statham DJ Statham Dixie J DJ
Andrews G Andrews Gavin G
Slagboom PE Slagboom P Eline PE
Boomsma DI Boomsma Dorret I DI
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 150B
ISSUE: 3
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2009
MONTH: Apr
DAY: 5
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
R01 HL055976-04 NHLBI NIH HHS United States
R01 HL55976 NHLBI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alleles
Australia
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 8
DNA isolation & purification
Depressive Disorder, Major genetics
Female genetics
Gene Frequency genetics
Genetic Linkage genetics
Genetic Markers genetics
Genetic Predisposition to Disease genetics
Humans genetics
Interviews as Topic genetics
Male genetics
Middle Aged genetics
Netherlands genetics
Pedigree genetics
Physical Chromosome Mapping genetics
Registries genetics
Siblings genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
9007-49-2 DNA
OTHER ID's
OTHERID SOURCE
NIHMS151574 NLM
PMC2784956 NLM
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