|
|
| PMID |
|
|
| TITLE |
|
| A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families. |
|
| ABSTRACT |
|
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking. |
| METHOD |
NlmCategory: METHODS |
| The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking. Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pairs design, the authors conducted nonparametric linkage analysis. |
| RESULTS |
NlmCategory: RESULTS |
| The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking. Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pairs design, the authors conducted nonparametric linkage analysis. In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking. Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pairs design, the authors conducted nonparametric linkage analysis. In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2011/05/17 06:00 |
| pubmed |
2011/05/17 06:00 |
| medline |
2011/10/01 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Pergadia ML |
|
Pergadia |
Michele L |
ML |
|
Department of Psychiatry, WashingtonUniversity School of Medicine, Saint Louis, MO 63110, USA. pergadim@psychiatry.wustl.edu |
| Glowinski AL |
|
Glowinski |
Anne L |
AL |
|
|
| Wray NR |
|
Wray |
Naomi R |
NR |
|
|
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
|
| Saccone SF |
|
Saccone |
Scott F |
SF |
|
|
| Loukola A |
|
Loukola |
Anu |
A |
|
|
| Broms U |
|
Broms |
Ulla |
U |
|
|
| Korhonen T |
|
Korhonen |
Tellervo |
T |
|
|
| Penninx BW |
|
Penninx |
Brenda W J H |
BW |
|
|
| Grant JD |
|
Grant |
Julia D |
JD |
|
|
| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
|
| Henders AK |
|
Henders |
Anjali K |
AK |
|
|
| Schrage AJ |
|
Schrage |
Andrew J |
AJ |
|
|
| Chou YL |
|
Chou |
Yi-Ling |
YL |
|
|
| Keskitalo-Vuokko K |
|
Keskitalo-Vuokko |
Kaisu |
K |
|
|
| Zhu Q |
|
Zhu |
Qin |
Q |
|
|
| Gordon SD |
|
Gordon |
Scott D |
SD |
|
|
| Vink JM |
|
Vink |
Jacqueline M |
JM |
|
|
| de Geus EJ |
|
de Geus |
Eco J C |
EJ |
|
|
| Macgregor S |
|
Macgregor |
Stuart |
S |
|
|
| Liu JZ |
|
Liu |
Jimmy Z |
JZ |
|
|
| Willemsen G |
|
Willemsen |
Gonneke |
G |
|
|
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Rice JP |
|
Rice |
John P |
JP |
|
|
| Goate AM |
|
Goate |
Alison M |
AM |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Kaprio J |
|
Kaprio |
Jaakko |
J |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 168 |
| ISSUE: 8 |
| TITLE: The American journal of psychiatry |
| ISOABBREVIATION: Am J Psychiatry |
| YEAR: 2011 |
| MONTH: Aug |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1535-7228 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Am J Psychiatry |
| COUNTRY: United States |
| ISSNLINKING: 0002-953X |
| NLMUNIQUEID: 0370512 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| CommentIn |
Am J Psychiatry. 2011 Aug;168(8):783-9 |
21813496 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 MH081802 |
NIMH NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| K08 DA019951-05 |
NIDA NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| P60 AA011998 |
NIAAA NIH HHS |
United States |
| DA024722 |
NIDA NIH HHS |
United States |
| P50 AA011998 |
NIAAA NIH HHS |
United States |
| R01 MH073151 |
NIMH NIH HHS |
United States |
| R01 AA007728 |
NIAAA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| R01 DA023668 |
NIDA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| R01 MH059160 |
NIMH NIH HHS |
United States |
| MH-073151 |
NIMH NIH HHS |
United States |
| MH-081802 |
NIMH NIH HHS |
United States |
| R01 MH-059160 |
NIMH NIH HHS |
United States |
| AA011998 |
NIAAA NIH HHS |
United States |
| AA015210 |
NIAAA NIH HHS |
United States |
| DA027995 |
NIDA NIH HHS |
United States |
| R56 DA012854 |
NIDA NIH HHS |
United States |
| T32 AA007580 |
NIAAA NIH HHS |
United States |
| K01 DA024722 |
NIDA NIH HHS |
United States |
| AA017915 |
NIAAA NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
| 230374 |
European Research Council |
International |
| R01 DA018267 |
NIDA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| R49CE001510 |
NCIPC CDC HHS |
United States |
| R01 DA012854 |
NIDA NIH HHS |
United States |
| K08 DA019951 |
NIDA NIH HHS |
United States |
| AA07580 |
NIAAA NIH HHS |
United States |
| R01 AA017915 |
NIAAA NIH HHS |
United States |
| R01 AA015210 |
NIAAA NIH HHS |
United States |
| AA017688 |
NIAAA NIH HHS |
United States |
| R37 AA007728 |
NIAAA NIH HHS |
United States |
| DA018267 |
NIDA NIH HHS |
United States |
| R25 DA027995 |
NIDA NIH HHS |
United States |
| R49 CE001510 |
NCIPC CDC HHS |
United States |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
| DA23668 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Alleles |
|
| Chromosomes, Human, Pair 3 |
genetics |
| Depressive Disorder, Major |
psychology |
| Diagnostic and Statistical Manual of Mental Disorders |
psychology |
| Diseases in Twins |
genetics |
| Finland |
genetics |
| Genetic Linkage |
genetics |
| Genome-Wide Association Study |
genetics |
| Genotype |
genetics |
| Humans |
genetics |
| Lod Score |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
| Queensland |
genetics |
| Receptors, Metabotropic Glutamate |
genetics |
| Smoking |
psychology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Receptors, Metabotropic Glutamate |
| 0 |
metabotropic glutamate receptor 7 |
|
| OTHER ID's |
|
|
|
