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| PMID |
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| TITLE |
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| Genetic predisposition to schizophrenia associated with increased use of cannabis. |
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| ABSTRACT |
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| Cannabis is the most commonly used illicit drug worldwide. With debate surrounding the legalization and control of use, investigating its health risks has become a pressing area of research. One established association is that between cannabis use and schizophrenia, a debilitating psychiatric disorder affecting ~1% of the population over their lifetime. Although considerable evidence implicates cannabis use as a component cause of schizophrenia, it remains unclear whether this is entirely due to cannabis directly raising risk of psychosis, or whether the same genes that increases psychosis risk may also increase risk of cannabis use. In a sample of 2082 healthy individuals, we show an association between an individual's burden of schizophrenia risk alleles and use of cannabis. This was significant both for comparing those who have ever versus never used cannabis (P=2.6 Ã? 10(-4)), and for quantity of use within users (P=3.0 Ã? 10(-3)). Although directly predicting only a small amount of the variance in cannabis use, these findings suggest that part of the association between schizophrenia and cannabis is due to a shared genetic aetiology. This form of gene-environment correlation is an important consideration when calculating the impact of environmental risk factors, including cannabis use. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2014/01/22 |
| revised |
2014/03/18 |
| accepted |
2014/04/22 |
| aheadofprint |
2014/06/24 |
| entrez |
2014/06/25 06:00 |
| pubmed |
2014/06/25 06:00 |
| medline |
2014/06/25 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Power RA |
|
Power |
R A |
RA |
|
1] MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK [2] Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia. |
| Verweij KJ |
|
Verweij |
K J H |
KJ |
|
Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University, Amsterdam, The Netherlands. |
| Zuhair M |
|
Zuhair |
M |
M |
|
MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK. |
| Montgomery GW |
|
Montgomery |
G W |
GW |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Henders AK |
|
Henders |
A K |
AK |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Heath AC |
|
Heath |
A C |
AC |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. |
| Madden PA |
|
Madden |
P A F |
PA |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. |
| Medland SE |
|
Medland |
S E |
SE |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Wray NR |
|
Wray |
N R |
NR |
|
Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia. |
| Martin NG |
|
Martin |
N G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
|
| VOLUME: 19 |
| ISSUE: 11 |
| TITLE: Molecular psychiatry |
| ISOABBREVIATION: Mol. Psychiatry |
| YEAR: 2014 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1476-5578 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Mol Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 1359-4184 |
| NLMUNIQUEID: 9607835 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07580 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| AA14041 |
NIAAA NIH HHS |
United States |
| AA17688 |
NIAAA NIH HHS |
United States |
| DA012854 |
NIDA NIH HHS |
United States |
| DA018267 |
NIDA NIH HHS |
United States |
| DA018660 |
NIDA NIH HHS |
United States |
| DA019951 |
NIDA NIH HHS |
United States |
| DA23668 |
NIDA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| K08 DA019951 |
NIDA NIH HHS |
United States |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| R01 AA010249 |
NIAAA NIH HHS |
United States |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
| R01 DA012854 |
NIDA NIH HHS |
United States |
| R01 DA023668 |
NIDA NIH HHS |
United States |
| R37 AA007728 |
NIAAA NIH HHS |
United States |
| T32 AA007580 |
NIAAA NIH HHS |
United States |
|
Department of Health |
United Kingdom |
|
Medical Research Council |
United Kingdom |
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| GENERAL NOTE |
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