Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22832960
TITLE
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
ABSTRACT
Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify significant genetic associations. We have assembled the largest sample to date of persons with genome-wide genotype data, who have been assessed with Cloninger's Temperament and Character Inventory. Sum scores for novelty seeking, harm avoidance, reward dependence and persistence have been measured in over 11,000 persons collected in four different cohorts. Our study had >80% power to identify genome-wide significant loci (P<1.25 × 10(-8), with correction for testing four scales) accounting for ≥0.4% of the phenotypic variance in temperament scales. Using meta-analysis techniques, gene-based tests and pathway analysis we have tested over 1.2 million single-nucleotide polymorphisms (SNPs) for association to each of the four temperament dimensions. We did not discover any SNPs, genes, or pathways to be significantly related to the four temperament dimensions, after correcting for multiple testing. Less than 1% of the variability in any temperament dimension appears to be accounted for by a risk score derived from the SNPs showing strongest association to the temperament dimensions. Elucidation of genetic loci significantly influencing temperament and personality will require potentially very large samples, and/or a more refined phenotype. Item response theory methodology may be a way to incorporate data from cohorts assessed with multiple personality instruments, and might be a method by which a large sample of a more refined phenotype could be acquired.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/07/27 06:00
pubmed 2012/07/27 06:00
medline 2013/03/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Service SK Service S K SK Center for Neurobehavioral Genetics, University of California, Los Angeles, CA, USA.
Verweij KJ Verweij K J H KJ
Lahti J Lahti J J
Congdon E Congdon E E
Ekelund J Ekelund J J
Hintsanen M Hintsanen M M
Räikkönen K Räikkönen K K
Lehtimäki T Lehtimäki T T
Kähönen M Kähönen M M
Widen E Widen E E
Taanila A Taanila A A
Veijola J Veijola J J
Heath AC Heath A C AC
Madden PA Madden P A F PA
Montgomery GW Montgomery G W GW
Sabatti C Sabatti C C
Järvelin MR Järvelin M-R MR
Palotie A Palotie A A
Raitakari O Raitakari O O
Viikari J Viikari J J
Martin NG Martin N G NG
Eriksson JG Eriksson J G JG
Keltikangas-Järvinen L Keltikangas-Järvinen L L
Wray NR Wray N R NR
Freimer NB Freimer N B NB
INVESTIGATORS
JOURNAL
VOLUME: 2
ISSUE:
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
1RL1MH083268-01 NIMH NIH HHS United States
5R01HL087679-02 NHLBI NIH HHS United States
5R01MH63706:02 NIMH NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
G0500539 Medical Research Council United Kingdom
G0600705 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
RL1MH083268 NIMH NIH HHS United States
T32NS048004 NINDS NIH HHS United States
UL1-DE019580 NIDCR NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia
Cohort Studies
Female
Finland
Genetic Heterogeneity
Genome-Wide Association Study
Genotype
Humans
Linkage Disequilibrium
Longitudinal Studies
Male
Middle Aged
Personality genetics
Personality Inventory statistics & numerical data
Phenotype statistics & numerical data
Polymorphism, Single Nucleotide genetics
Psychometrics statistics & numerical data
Reproducibility of Results statistics & numerical data
Temperament statistics & numerical data
Twins psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3365256 NLM