Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
20691247
TITLE
A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
ABSTRACT
Variation in personality traits is 30-60% attributed to genetic influences. Attempts to unravel these genetic influences at the molecular level have, so far, been inconclusive. We performed the first genome-wide association study of Cloninger's temperament scales in a sample of 5117 individuals, in order to identify common genetic variants underlying variation in personality. Participants' scores on Harm Avoidance, Novelty Seeking, Reward Dependence, and Persistence were tested for association with 1,252,387 genetic markers. We also performed gene-based association tests and biological pathway analyses. No genetic variants that significantly contribute to personality variation were identified, while our sample provides over 90% power to detect variants that explain only 1% of the trait variance. This indicates that individual common genetic variants of this size or greater do not contribute to personality trait variation, which has important implications regarding the genetic architecture of personality and the evolutionary mechanisms by which heritable variation is maintained.
Copyright 2010 Elsevier B.V. All rights reserved.
DATE PUBLISHED
2010 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/04/04
revised 2010/07/16
accepted 2010/07/25
aheadofprint 2010/08/04
entrez 2010/08/10 06:00
pubmed 2010/08/10 06:00
medline 2011/01/12 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Verweij KJ Verweij Karin J H KJ Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. karin.verweij@qimr.edu.au
Zietsch BP Zietsch Brendan P BP
Medland SE Medland Sarah E SE
Gordon SD Gordon Scott D SD
Benyamin B Benyamin Beben B
Nyholt DR Nyholt Dale R DR
McEvoy BP McEvoy Brian P BP
Sullivan PF Sullivan Patrick F PF
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Henders AK Henders Anjali K AK
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Wray NR Wray Naomi R NR
INVESTIGATORS
JOURNAL
VOLUME: 85
ISSUE: 2
TITLE: Biological psychology
ISOABBREVIATION: Biol Psychol
YEAR: 2010
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1873-6246
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Biol Psychol
COUNTRY: Netherlands
ISSNLINKING: 0301-0511
NLMUNIQUEID: 0375566
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
R01 AA007535 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Exploratory Behavior
Female
Genome-Wide Association Study
Genotype
Humans
Life Style
Male
Middle Aged
Personality genetics
Reward genetics
Surveys and Questionnaires genetics
Temperament genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS235348 NLM
PMC2963646 NLM