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| PMID |
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| TITLE |
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| Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins. |
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| ABSTRACT |
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| Cytokines and vitamin D both have a role in modulating the immune system, and are also potentially useful biomarkers in mental illnesses such as major depressive disorder (MDD) and schizophrenia. Studying the variability of cytokines and vitamin D in a healthy population sample may add to understanding the association between these biomarkers and mental illness. To assess genetic and environmental contributions to variation in circulating levels of cytokines and vitamin D (25-hydroxy vitamin D: 25(OH)D3), we analyzed data from a healthy adolescent twin cohort (mean age 16.2 years; standard deviation 0.25). Plasma cytokine measures were available for 400 individuals (85 MZ, 115 DZ pairs), dried blood spot sample vitamin D measures were available for 378 individuals (70 MZ, 118 DZ pairs). Heritability estimates were moderate but significant for the cytokines transforming growth factor-β1 (TGF-β1), 0.57 (95% CI 0.26-0.80) and tumor necrosis factor-receptor type 1 (TNFR1), 0.50 (95% CI 0.11-0.63) respectively. Measures of 25(OH)D3 were within normal range and heritability was estimated to be high (0.86, 95% CI 0.61-0.94). Assays of other cytokines did not generate meaningful results. These potential biomarkers may be useful in mental illness, with further research warranted in larger sample sizes. They may be particularly important in adolescents with mental illness where diagnostic uncertainty poses a significant clinical challenge. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2014/12/04 06:00 |
| pubmed |
2014/12/04 06:00 |
| medline |
2014/12/04 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Mills NT |
|
Mills |
Natalie T |
NT |
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Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Wright MJ |
|
Wright |
Margie J |
MJ |
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Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Henders AK |
|
Henders |
Anjali K |
AK |
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Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Eyles DW |
|
Eyles |
Darryl W |
DW |
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Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
| Baune BT |
|
Baune |
Bernhard T |
BT |
|
Discipline of Psychiatry,School of Medicine,University of Adelaide,Adelaide,South Australia,Australia. |
| McGrath JJ |
|
McGrath |
John J |
JJ |
|
Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
| Byrne EM |
|
Byrne |
Enda M |
EM |
|
Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
| Hansell NK |
|
Hansell |
Narelle K |
NK |
|
Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Birosova E |
|
Birosova |
Eva |
E |
|
School of Medicine,James Cook University,Townsville,Queensland,Australia. |
| Scott JG |
|
Scott |
James G |
JG |
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Metro North Mental Health,Royal Brisbane and Women's Hospital,Brisbane,Queensland,Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
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Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Wray NR |
|
Wray |
Naomi R |
NR |
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Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
| Vinkhuyzen AA |
|
Vinkhuyzen |
Anna A E |
AA |
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Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2014 |
| MONTH: Dec |
| DAY: 3 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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