Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25466434
TITLE
Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins.
ABSTRACT
Cytokines and vitamin D both have a role in modulating the immune system, and are also potentially useful biomarkers in mental illnesses such as major depressive disorder (MDD) and schizophrenia. Studying the variability of cytokines and vitamin D in a healthy population sample may add to understanding the association between these biomarkers and mental illness. To assess genetic and environmental contributions to variation in circulating levels of cytokines and vitamin D (25-hydroxy vitamin D: 25(OH)D3), we analyzed data from a healthy adolescent twin cohort (mean age 16.2 years; standard deviation 0.25). Plasma cytokine measures were available for 400 individuals (85 MZ, 115 DZ pairs), dried blood spot sample vitamin D measures were available for 378 individuals (70 MZ, 118 DZ pairs). Heritability estimates were moderate but significant for the cytokines transforming growth factor-β1 (TGF-β1), 0.57 (95% CI 0.26-0.80) and tumor necrosis factor-receptor type 1 (TNFR1), 0.50 (95% CI 0.11-0.63) respectively. Measures of 25(OH)D3 were within normal range and heritability was estimated to be high (0.86, 95% CI 0.61-0.94). Assays of other cytokines did not generate meaningful results. These potential biomarkers may be useful in mental illness, with further research warranted in larger sample sizes. They may be particularly important in adolescents with mental illness where diagnostic uncertainty poses a significant clinical challenge.
DATE PUBLISHED
2014 Dec 3
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2014/12/04 06:00
pubmed 2014/12/04 06:00
medline 2014/12/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Mills NT Mills Natalie T NT Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Wright MJ Wright Margie J MJ Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Henders AK Henders Anjali K AK Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Eyles DW Eyles Darryl W DW Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
Baune BT Baune Bernhard T BT Discipline of Psychiatry,School of Medicine,University of Adelaide,Adelaide,South Australia,Australia.
McGrath JJ McGrath John J JJ Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
Byrne EM Byrne Enda M EM Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
Hansell NK Hansell Narelle K NK Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Birosova E Birosova Eva E School of Medicine,James Cook University,Townsville,Queensland,Australia.
Scott JG Scott James G JG Metro North Mental Health,Royal Brisbane and Women's Hospital,Brisbane,Queensland,Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Montgomery GW Montgomery Grant W GW Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Wray NR Wray Naomi R NR Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
Vinkhuyzen AA Vinkhuyzen Anna A E AA Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2014
MONTH: Dec
DAY: 3
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
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