Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data.
The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic association between personality and MDD and BD by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders. Polygenic scores reflect the weighted sum of multiple single-nucleotide polymorphism alleles associated with the trait for an individual and were based on a meta-analysis of genome-wide association studies for personality traits including 13,835 subjects. Polygenic scores were tested for MDD in the combined Genetic Association Information Network (GAIN-MDD) and MDD2000+ samples (N=8921) and for BD in the combined Systematic Treatment Enhancement Program for Bipolar Disorder and Wellcome Trust Case-Control Consortium samples (N=6329) using logistic regression analyses. At the phenotypic level, personality dimensions were associated with MDD and BD. Polygenic neuroticism scores were significantly positively associated with MDD, whereas polygenic extraversion scores were significantly positively associated with BD. The explained variance of MDD and BD, ∼0.1%, was highly comparable to the variance explained by the polygenic personality scores in the corresponding personality traits themselves (between 0.1 and 0.4%). This indicates that the proportions of variance explained in mood disorders are at the upper limit of what could have been expected. This study suggests shared genetic risk factors for neuroticism and MDD on the one hand and for extraversion and BD on the other.
entrez 2012/07/27 06:00
pubmed 2011/01/01 00:00
medline 2013/04/05 06:00
Middeldorp CM Middeldorp C M CM Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
de Moor MH de Moor M H M MH
McGrath LM McGrath L M LM
Gordon SD Gordon S D SD
Blackwood DH Blackwood D H DH
Costa PT Costa P T PT
Terracciano A Terracciano A A
Krueger RF Krueger R F RF
de Geus EJ de Geus E J C EJ
Nyholt DR Nyholt D R DR
Tanaka T Tanaka T T
Esko T Esko T T
Madden PA Madden P A F PA
Derringer J Derringer J J
Amin N Amin N N
Willemsen G Willemsen G G
Hottenga JJ Hottenga J-J JJ
Distel MA Distel M A MA
Uda M Uda M M
Sanna S Sanna S S
Spinhoven P Spinhoven P P
Hartman CA Hartman C A CA
Ripke S Ripke S S
Sullivan PF Sullivan P F PF
Realo A Realo A A
Allik J Allik J J
Heath AC Heath A C AC
Pergadia ML Pergadia M L ML
Agrawal A Agrawal A A
Lin P Lin P P
Grucza RA Grucza R A RA
Widen E Widen E E
Cousminer DL Cousminer D L DL
Eriksson JG Eriksson J G JG
Palotie A Palotie A A
Barnett JH Barnett J H JH
Lee PH Lee P H PH
Luciano M Luciano M M
Tenesa A Tenesa A A
Davies G Davies G G
Lopez LM Lopez L M LM
Hansell NK Hansell N K NK
Medland SE Medland S E SE
Ferrucci L Ferrucci L L
Schlessinger D Schlessinger D D
Montgomery GW Montgomery G W GW
Wright MJ Wright M J MJ
Aulchenko YS Aulchenko Y S YS
Janssens AC Janssens A C J W AC
Oostra BA Oostra B A BA
Metspalu A Metspalu A A
Abecasis GR Abecasis G R GR
Deary IJ Deary I J IJ
Räikkönen K Räikkönen K K
Bierut LJ Bierut L J LJ
Martin NG Martin N G NG
Wray NR Wray N R NR
van Duijn CM van Duijn C M CM
Smoller JW Smoller J W JW
Penninx BW Penninx B W J H BW
Boomsma DI Boomsma D I DI
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2011
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
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076113 Wellcome Trust United Kingdom
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BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
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DA12854 NIDA NIH HHS United States
G0700704 Medical Research Council United Kingdom
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P01CA89392 NCI NIH HHS United States
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ZIA AG000197-03 Intramural NIH HHS United States
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Biotechnology and Biological Sciences Research Council United Kingdom
Medical Research Council United Kingdom
Bipolar Disorder genetics
Depressive Disorder, Major genetics
Female genetics
Genome-Wide Association Study genetics
Humans genetics
Male genetics
Meta-Analysis as Topic genetics
Middle Aged genetics
Multifactorial Inheritance genetics
Personality genetics
Personality Inventory genetics
Registries genetics
PMC3309491 NLM