Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22833196
TITLE
The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data.
ABSTRACT
The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic association between personality and MDD and BD by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders. Polygenic scores reflect the weighted sum of multiple single-nucleotide polymorphism alleles associated with the trait for an individual and were based on a meta-analysis of genome-wide association studies for personality traits including 13,835 subjects. Polygenic scores were tested for MDD in the combined Genetic Association Information Network (GAIN-MDD) and MDD2000+ samples (N=8921) and for BD in the combined Systematic Treatment Enhancement Program for Bipolar Disorder and Wellcome Trust Case-Control Consortium samples (N=6329) using logistic regression analyses. At the phenotypic level, personality dimensions were associated with MDD and BD. Polygenic neuroticism scores were significantly positively associated with MDD, whereas polygenic extraversion scores were significantly positively associated with BD. The explained variance of MDD and BD, ∼0.1%, was highly comparable to the variance explained by the polygenic personality scores in the corresponding personality traits themselves (between 0.1 and 0.4%). This indicates that the proportions of variance explained in mood disorders are at the upper limit of what could have been expected. This study suggests shared genetic risk factors for neuroticism and MDD on the one hand and for extraversion and BD on the other.
DATE PUBLISHED
2011
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/07/27 06:00
pubmed 2011/01/01 00:00
medline 2013/04/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Middeldorp CM Middeldorp C M CM Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. cm.middeldorp@psy.vu.nl
de Moor MH de Moor M H M MH
McGrath LM McGrath L M LM
Gordon SD Gordon S D SD
Blackwood DH Blackwood D H DH
Costa PT Costa P T PT
Terracciano A Terracciano A A
Krueger RF Krueger R F RF
de Geus EJ de Geus E J C EJ
Nyholt DR Nyholt D R DR
Tanaka T Tanaka T T
Esko T Esko T T
Madden PA Madden P A F PA
Derringer J Derringer J J
Amin N Amin N N
Willemsen G Willemsen G G
Hottenga JJ Hottenga J-J JJ
Distel MA Distel M A MA
Uda M Uda M M
Sanna S Sanna S S
Spinhoven P Spinhoven P P
Hartman CA Hartman C A CA
Ripke S Ripke S S
Sullivan PF Sullivan P F PF
Realo A Realo A A
Allik J Allik J J
Heath AC Heath A C AC
Pergadia ML Pergadia M L ML
Agrawal A Agrawal A A
Lin P Lin P P
Grucza RA Grucza R A RA
Widen E Widen E E
Cousminer DL Cousminer D L DL
Eriksson JG Eriksson J G JG
Palotie A Palotie A A
Barnett JH Barnett J H JH
Lee PH Lee P H PH
Luciano M Luciano M M
Tenesa A Tenesa A A
Davies G Davies G G
Lopez LM Lopez L M LM
Hansell NK Hansell N K NK
Medland SE Medland S E SE
Ferrucci L Ferrucci L L
Schlessinger D Schlessinger D D
Montgomery GW Montgomery G W GW
Wright MJ Wright M J MJ
Aulchenko YS Aulchenko Y S YS
Janssens AC Janssens A C J W AC
Oostra BA Oostra B A BA
Metspalu A Metspalu A A
Abecasis GR Abecasis G R GR
Deary IJ Deary I J IJ
Räikkönen K Räikkönen K K
Bierut LJ Bierut L J LJ
Martin NG Martin N G NG
Wray NR Wray N R NR
van Duijn CM van Duijn C M CM
Smoller JW Smoller J W JW
Penninx BW Penninx B W J H BW
Boomsma DI Boomsma D I DI
INVESTIGATORS
JOURNAL
VOLUME: 1
ISSUE:
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2011
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Am J Psychiatry. 2000 Oct;157(10):1552-62 11007705
Cites Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):950-9 19180564
Cites Biol Psychiatry. 2003 Jun 1;53(11):1028-42 12788248
Cites Am J Psychiatry. 2004 Oct;161(10):1814-21 15465978
Cites J Affect Disord. 1986 Jul-Aug;11(1):81-9 2944932
Cites Arch Gen Psychiatry. 1993 Nov;50(11):853-62 8215811
Cites J Pers. 1996 Sep;64(3):577-91 8776880
Cites Biol Psychiatry. 2009 Dec 15;66(12):1131-8 19748081
Cites Mol Psychiatry. 2010 Feb;15(2):146-53 19078961
Cites Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5082-7 20202923
Cites Psychol Med. 2010 May;40(5):801-6 19732485
Cites Mol Psychiatry. 2010 Jun;15(6):647-56 18957941
Cites J Pers Soc Psychol. 2010 Jun;98(6):995-1008 20515254
Cites Psychol Med. 2010 Aug;40(8):1357-66 19811701
Cites Bioinformatics. 2010 Sep 1;26(17):2190-1 20616382
Cites Psychol Bull. 2010 Sep;136(5):768-821 20804236
Cites Am J Psychiatry. 2010 Oct;167(10):1254-63 20713499
Cites Twin Res Hum Genet. 2010 Dec;13(6):517-24 21142928
Cites J Pers Soc Psychol. 2011 Mar;100(3):545-56 21244174
Cites Mol Psychiatry. 2011 Jul;16(7):773-83 20567237
Cites Psychol Med. 2011 Aug;41(8):1593-604 21134316
Cites Mol Psychiatry. 2011 Oct;16(10):996-1005 21826061
Cites Mol Psychiatry. 2012 Jan;17(1):36-48 21042317
Cites Mol Psychiatry. 2012 Mar;17(3):337-49 21173776
Cites Psychiatry Res. 1997 May 5;70(2):83-94 9194202
Cites Twin Res. 2004 Dec;7(6):637-48 15607015
Cites J Affect Disord. 2005 Mar;85(1-2):207-15 15780691
Cites Ann Hum Genet. 2005 May;69(Pt 3):288-95 15845033
Cites J Pers Assess. 2005 Jun;84(3):261-70 15907162
Cites Psychol Med. 2005 May;35(5):611-24 15918338
Cites N Engl J Med. 2005 Oct 27;353(17):1802-9 16251536
Cites Twin Res Hum Genet. 2005 Dec;8(6):609-15 16354503
Cites Arch Gen Psychiatry. 2006 Oct;63(10):1113-20 17015813
Cites Diabetologia. 2006 Dec;49(12):2853-8 17096117
Cites PLoS Genet. 2006 Aug 25;2(8):e132 16934002
Cites Twin Res Hum Genet. 2006 Dec;9(6):849-57 17254420
Cites Am J Hum Genet. 2007 May;80(5):856-66 17436240
Cites Nature. 2007 Jun 7;447(7145):661-78 17554300
Cites Nat Genet. 2007 Jul;39(7):906-13 17572673
Cites Psychol Med. 2007 Aug;37(8):1163-72 17407614
Cites Am J Hum Genet. 2007 Sep;81(3):559-75 17701901
Cites Am J Hum Genet. 2007 Nov;81(5):1084-97 17924348
Cites BMC Geriatr. 2007;7:28 18053258
Cites Eur J Hum Genet. 2008 Mar;16(3):335-42 18197199
Cites Psychosom Med. 2008 Apr;70(3):306-13 18378874
Cites Psychol Med. 2008 Sep;38(9):1219-29 17988414
Cites Int J Methods Psychiatr Res. 2008;17(3):121-40 18763692
Cites J Abnorm Psychol. 2008 Nov;117(4):812-25 19025228
Cites Mol Psychiatry. 2009 Jan;14(1):10-7 19002139
Cites Lancet. 2009 Jan 17;373(9659):234-9 19150704
Cites Am J Hum Genet. 2009 Feb;84(2):210-23 19200528
Cites Mol Psychiatry. 2009 Apr;14(4):359-75 19065144
Cites Nature. 2009 Aug 6;460(7256):748-52 19571811
Cites Annu Rev Genomics Hum Genet. 2009;10:387-406 19715440
Cites Psychiatry Res. 2009 Sep 30;169(2):159-63 19699536
Cites Arch Gen Psychiatry. 2003 May;60(5):497-502 12742871
GRANTS
GRANTID AGENCY COUNTRY
076113 Wellcome Trust United Kingdom
AA07535 NIAAA NIH HHS United States
AA07580 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
DA019951 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
G0700704 Medical Research Council United Kingdom
HHSN268200782096C PHS HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
N01-AG-1-2109 NIA NIH HHS United States
P01 CA089392 NCI NIH HHS United States
P01CA89392 NCI NIH HHS United States
R01 079799 PHS HHS United States
R01 DA013423 NIDA NIH HHS United States
R01 DA019963 NIDA NIH HHS United States
R01 MH059160 NIMH NIH HHS United States
U01 HG004422 NHGRI NIH HHS United States
U01 HG004446 NHGRI NIH HHS United States
U01HG004438 NHGRI NIH HHS United States
U10 AA008401 NIAAA NIH HHS United States
U10AA008401 NIAAA NIH HHS United States
Z99 AG999999 Intramural NIH HHS United States
ZIA AG000196-03 Intramural NIH HHS United States
ZIA AG000196-04 Intramural NIH HHS United States
ZIA AG000197-03 Intramural NIH HHS United States
ZIA AG000197-04 Intramural NIH HHS United States
Biotechnology and Biological Sciences Research Council United Kingdom
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Bipolar Disorder genetics
Depressive Disorder, Major genetics
Female genetics
Genome-Wide Association Study genetics
Humans genetics
Male genetics
Meta-Analysis as Topic genetics
Middle Aged genetics
Multifactorial Inheritance genetics
Personality genetics
Personality Inventory genetics
Registries genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3309491 NLM