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| PMID |
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| TITLE |
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| Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. |
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| ABSTRACT |
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| Several independent linkage studies have identified chromosome 4p15-p16 as a putative region of susceptibility for bipolar disorder (BP), schizophrenia (SCZ) and related phenotypes. Previously, we identified two subregions (B and D) of the 4p15-p16 region that are shared by three of four 4p-linked families examined. Here, we describe a large-scale association analysis of regions B and D (3.8 and 4.5 Mb, respectively). We selected 408 haplotype-tagging single nucleotide polymorphisms (SNPs) on a block-by-block basis from the International HapMap project and tested them in 368 BP, 386 SCZ and 458 control individuals. Nominal significance thresholds were determined using principal component analysis as implemented in the program SNPSpD. In region B, overlapping SNPs and haplotypes met the region-wide threshold (P
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2007/04/24 |
| pubmed |
2007/04/26 09:00 |
| medline |
2008/01/10 09:00 |
| entrez |
2007/04/26 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Christoforou A |
|
Christoforou |
A |
A |
|
Medical Genetics Section, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, UK. a.christoforou@ed.ac.uk |
| Le Hellard S |
|
Le Hellard |
S |
S |
|
|
| Thomson PA |
|
Thomson |
P A |
PA |
|
|
| Morris SW |
|
Morris |
S W |
SW |
|
|
| Tenesa A |
|
Tenesa |
A |
A |
|
|
| Pickard BS |
|
Pickard |
B S |
BS |
|
|
| Wray NR |
|
Wray |
N R |
NR |
|
|
| Muir WJ |
|
Muir |
W J |
WJ |
|
|
| Blackwood DH |
|
Blackwood |
D H |
DH |
|
|
| Porteous DJ |
|
Porteous |
D J |
DJ |
|
|
| Evans KL |
|
Evans |
K L |
KL |
|
|
|
| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 12 |
| ISSUE: 11 |
| TITLE: Molecular psychiatry |
| ISOABBREVIATION: Mol. Psychiatry |
| YEAR: 2007 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1359-4184 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Mol Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 1359-4184 |
| NLMUNIQUEID: 9607835 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
|
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| G0100266 |
Medical Research Council |
United Kingdom |
|
Wellcome Trust |
United Kingdom |
|
| GENERAL NOTE |
|
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| KEYWORDS |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Bipolar Disorder |
etiology |
| Chi-Square Distribution |
etiology |
| Chromosome Mapping |
etiology |
| Chromosomes, Human, Pair 4 |
etiology |
| Female |
etiology |
| Genetic Predisposition to Disease |
etiology |
| Genotype |
etiology |
| Haplotypes |
etiology |
| Humans |
etiology |
| Lod Score |
etiology |
| Male |
etiology |
| Polymorphism, Single Nucleotide |
etiology |
| Principal Component Analysis |
etiology |
| Schizophrenia |
genetics |
|
| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
|
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| OTHER ID's |
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