Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23756378
TITLE
Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin.
ABSTRACT
Our understanding of major depressive disorder (MDD) has focused on the influence of genetic variation and environmental risk factors. Growing evidence suggests the additional role of epigenetic mechanisms influencing susceptibility for complex traits. DNA sequence within discordant monozygotic twin (MZT) pairs is virtually identical; thus, they represent a powerful design for studying the contribution of epigenetic factors to disease liability. The aim of this study was to investigate whether specific methylation profiles in white blood cells could contribute to the aetiology of MDD. Participants were drawn from the Queensland Twin Registry and comprised 12 MZT pairs discordant for MDD and 12 MZT pairs concordant for no MDD and low neuroticism. Bisulphite treatment and genome-wide interrogation of differentially methylated CpG sites using the Illumina Human Methylation 450 BeadChip were performed in WBC-derived DNA. No overall difference in mean global methylation between cases and their unaffected co-twins was found; however, the differences in females was significant (P=0.005). The difference in variance across all probes between affected and unaffected twins was highly significant (P<2.2 × 10⁻¹⁶), with 52.4% of probes having higher variance in cases (binomial P-value<2.2 × 10⁻¹⁶). No significant differences in methylation were observed between discordant MZT pairs and their matched concordant MZT (permutation minimum P=0.11) at any individual probe. Larger samples are likely to be needed to identify true associations between methylation differences at specific CpG sites.
DATE PUBLISHED
2013
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2013/06/13 06:00
pubmed 2013/06/13 06:00
medline 2013/12/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Byrne EM Byrne E M EM Queensland Brain Institute, The University of Queensland, Queensland, Australia. Enda.byrne@uq.edu.au
Carrillo-Roa T Carrillo-Roa T T
Henders AK Henders A K AK
Bowdler L Bowdler L L
McRae AF McRae A F AF
Heath AC Heath A C AC
Martin NG Martin N G NG
Montgomery GW Montgomery G W GW
Krause L Krause L L
Wray NR Wray N R NR
INVESTIGATORS
JOURNAL
VOLUME: 3
ISSUE:
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2013
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
K05 AA017688 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Anxiety Disorders psychology
DNA Methylation genetics
Depressive Disorder, Major metabolism
Diseases in Twins psychology
Female psychology
Humans psychology
Male psychology
Registries psychology
Sex Factors psychology
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
SUPPLMESHNAME SUPPLMESHTYPE
Neuroticism Disease
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3693404 NLM