Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23728906
TITLE
A genome-wide association study of sleep habits and insomnia.
ABSTRACT
Several aspects of sleep behavior such as timing, duration and quality have been demonstrated to be heritable. To identify common variants that influence sleep traits in the population, we conducted a genome-wide association study of six sleep phenotypes assessed by questionnaire in a sample of 2,323 individuals from the Australian Twin Registry. Genotyping was performed on the Illumina 317, 370, and 610K arrays and the SNPs in common between platforms were used to impute non-genotyped SNPs. We tested for association with more than 2,000,000 common polymorphisms across the genome. While no SNPs reached the genome-wide significance threshold, we identified a number of associations in plausible candidate genes. Most notably, a group of SNPs in the third intron of the CACNA1C gene ranked as most significant in the analysis of sleep latency (P = 1.3 × 10⁻⁶). We attempted to replicate this association in an independent sample from the Chronogen Consortium (n = 2,034), but found no evidence of association (P = 0.73). We have identified several other suggestive associations that await replication in an independent sample. We did not replicate the results from previous genome-wide analyses of self-reported sleep phenotypes after correction for multiple testing.
Copyright 2013 Wiley Periodicals, Inc.
DATE PUBLISHED
2013 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/06/27
accepted 2013/04/11
aheadofprint 2013/05/31
entrez 2013/06/04 06:00
pubmed 2013/06/04 06:00
medline 2013/10/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Byrne EM Byrne Enda M EM Queensland Institute of Medical Research, Brisbane, Queensland, Australia. e.byrne3@uq.edu.au
Gehrman PR Gehrman Philip R PR
Medland SE Medland Sarah E SE
Nyholt DR Nyholt Dale R DR
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Hickie IB Hickie Ian B IB
Van Duijn CM Van Duijn Cornelia M CM
Henders AK Henders Anjali K AK
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Wray NR Wray Naomi R NR
Chronogen Consortium
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Amin Najaf N
Allebrandt Karla V KV
Müller-Myhsok Bertram B
Teder-Laving Maris M
Hayward Caroline C
Esko Tõnu T
van Mill Josine G JG
Melville Scott A SA
Vogelzangs Nicole N
Campbell Harry H
Borovecki Fran F
Huffman Jennifer E JE
Wichmann Erich E
Oostra Ben A BA
Wright Alan F AF
Wilson James F JF
Pramstaller Peter P PP
Hicks Andrew A AA
Merrow Martha M
Rudan Igor I
Penninx Brenda W BW
Metspalu Andres A
Meitinger Thomas T
Roenneberg Till T
van Duijn Cornelia M CM
JOURNAL
VOLUME: 162B
ISSUE: 5
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2013
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites PLoS One. 2010;5(2):e9259 20174623
Cites Nat Genet. 2009 Dec;41(12):1303-7 19915576
Cites Neuropsychopharmacology. 2010 May;35(6):1279-89 20072116
Cites Am J Hum Genet. 2010 Jul 9;87(1):139-45 20598278
Cites Hum Genet. 2010 Oct;128(4):433-41 20677014
Cites Mol Psychiatry. 2010 Oct;15(10):1016-22 19621016
Cites Nature. 2010 Oct 14;467(7317):832-8 20881960
Cites Nat Genet. 2010 Nov;42(11):937-48 20935630
Cites Sleep. 2012 Jul;35(7):967-75 22754043
Cites Mol Psychiatry. 2013 Jan;18(1):122-32 22105623
Cites J Sleep Res. 2000 Mar;9(1):49-54 10733689
Cites Nat Genet. 2002 Jan;30(1):97-101 11731797
Cites Sleep Med Rev. 2002 Apr;6(2):97-111 12531146
Cites Am J Med Genet B Neuropsychiatr Genet. 2003 Aug 15;121B(1):35-8 12898572
Cites Psychiatr Neurol (Basel). 1966;152(6):363-9 5958255
Cites Br J Psychol. 1969 May;60(2):203-8 5787679
Cites Psychol Med. 1975 Feb;5(1):83-8 1118533
Cites Sleep. 1980;3(1):59-65 7466126
Cites Sleep. 1983;6(3):179-85 6684786
Cites Sleep. 1990 Aug;13(4):318-35 2267475
Cites Sleep. 1994 Aug;17(5):456-61 7991958
Cites Twin Res. 1998 Dec;1(4):176-88 10100809
Cites J Psychosom Res. 2005 Mar;58(3):271-8 15865952
Cites Sleep. 2005 Apr;28(4):395-409 16171284
Cites FEBS J. 2005 Nov;272(22):5689-93 16279934
Cites Curr Probl Cardiol. 2005 Dec;30(12):625-62 16301095
Cites Chronobiol Int. 2006;23(1-2):63-70 16687280
Cites Cancer Res. 2006 Oct 1;66(19):9445-52 17018599
Cites Curr Biol. 2007 Apr 3;17(7):613-8 17346965
Cites Nature. 2007 Jun 7;447(7145):661-78 17554300
Cites Am J Hum Genet. 2007 Sep;81(3):559-75 17701901
Cites BMC Med Genet. 2007;8 Suppl 1:S9 17903308
Cites Am J Hum Genet. 2007 Nov;81(5):913-26 17924335
Cites Sleep. 2007 Oct;30(10):1378-86 17969472
Cites Curr Biol. 2007 Nov 20;17(22):1996-2000 17964164
Cites PLoS One. 2007;2(12):e1274 18060068
Cites Sleep. 2007 Dec;30(12):1739-45 18246983
Cites Genome Res. 2008 Apr;18(4):640-3 18256235
Cites Ann Neurol. 2008 Oct;64(4):455-60 18688819
Cites Am J Epidemiol. 2009 Jan 15;169(2):206-13 19015202
Cites Nat Genet. 2008 Sep;40(9):1056-8 18711365
Cites Sleep. 2009 Feb;32(2):189-99 19238806
Cites PLoS Genet. 2009 Jun;5(6):e1000529 19543373
Cites Annu Rev Genomics Hum Genet. 2009;10:387-406 19715440
Cites Nature. 2009 Oct 8;461(7265):747-53 19812666
Cites JAMA. 2009 Nov 11;302(18):2028-9 19903925
Cites Am J Hum Genet. 2009 Nov;85(5):750-5 19896111
Cites BMC Bioinformatics. 2010;11:134 20233392
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
R01 AA007535 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia
Female
Genome-Wide Association Study
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Registries
Sleep genetics
Sleep Initiation and Maintenance Disorders genetics
Twin Studies as Topic genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS573147 NLM
PMC4083458 NLM