Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22832902
TITLE
Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion.
ABSTRACT
The personality traits of neuroticism and extraversion are predictive of a number of social and behavioural outcomes and psychiatric disorders. Twin and family studies have reported moderate heritability estimates for both traits. Few associations have been reported between genetic variants and neuroticism/extraversion, but hardly any have been replicated. Moreover, the ones that have been replicated explain only a small proportion of the heritability (<~2%). Using genome-wide single-nucleotide polymorphism (SNP) data from ~12,000 unrelated individuals we estimated the proportion of phenotypic variance explained by variants in linkage disequilibrium with common SNPs as 0.06 (s.e. = 0.03) for neuroticism and 0.12 (s.e. = 0.03) for extraversion. In an additional series of analyses in a family-based sample, we show that while for both traits ~45% of the phenotypic variance can be explained by pedigree data (that is, expected genetic similarity) one third of this can be explained by SNP data (that is, realized genetic similarity). A part of the so-called 'missing heritability' has now been accounted for, but some of the reported heritability is still unexplained. Possible explanations for the remaining missing heritability are that: (i) rare variants that are not captured by common SNPs on current genotype platforms make a major contribution; and/ or (ii) the estimates of narrow sense heritability from twin and family studies are biased upwards, for example, by not properly accounting for nonadditive genetic factors and/or (common) environmental factors.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/07/27 06:00
pubmed 2012/07/27 06:00
medline 2013/03/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Vinkhuyzen AA Vinkhuyzen A A E AA Queensland Institute of Medical Research, Brisbane, Queensland, Australia. anna.vinkhuyzen@uq.edu.au
Pedersen NL Pedersen N L NL
Yang J Yang J J
Lee SH Lee S H SH
Magnusson PK Magnusson P K E PK
Iacono WG Iacono W G WG
McGue M McGue M M
Madden PA Madden P A F PA
Heath AC Heath A C AC
Luciano M Luciano M M
Payton A Payton A A
Horan M Horan M M
Ollier W Ollier W W
Pendleton N Pendleton N N
Deary IJ Deary I J IJ
Montgomery GW Montgomery G W GW
Martin NG Martin N G NG
Visscher PM Visscher P M PM
Wray NR Wray N R NR
INVESTIGATORS
JOURNAL
VOLUME: 2
ISSUE:
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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ErratumIn Transl Psychiatry. 2012;2:e125 19812666
GRANTS
GRANTID AGENCY COUNTRY
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
BB/F022441/1 Biotechnology and Biological Sciences Research Council United Kingdom
CZB/4/505 Chief Scientist Office United Kingdom
ETM/55 Chief Scientist Office United Kingdom
G0100594 Medical Research Council United Kingdom
G0700704 Medical Research Council United Kingdom
G0701120 Medical Research Council United Kingdom
G0901461 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
R01 AA009367 NIAAA NIH HHS United States
R01 AA09367 NIAAA NIH HHS United States
R01 AA11886 NIAAA NIH HHS United States
R01 DA05147 NIDA NIH HHS United States
R01 DA13240 NIDA NIH HHS United States
R37 DA005147 NIDA NIH HHS United States
U01 DA024417 NIDA NIH HHS United States
U01 DK066134 NIDDK NIH HHS United States
Biotechnology and Biological Sciences Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Anxiety Disorders genetics
Character genetics
Child genetics
Cohort Studies genetics
Diseases in Twins psychology
Extraversion (Psychology) psychology
Female psychology
Gene-Environment Interaction psychology
Genetic Variation genetics
Genome-Wide Association Study genetics
Humans genetics
Linear Models genetics
Male genetics
Middle Aged genetics
Phenotype genetics
Polymorphism, Single Nucleotide genetics
Sex Factors genetics
SUPPLEMENTARY MESH
SUPPLMESHNAME SUPPLMESHTYPE
Neuroticism Disease
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3337075 NLM