Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24694013
TITLE
Hypermethylation in the ZBTB20 gene is associated with major depressive disorder.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Although genetic variation is believed to contribute to an individual's susceptibility to major depressive disorder, genome-wide association studies have not yet identified associations that could explain the full etiology of the disease. Epigenetics is increasingly believed to play a major role in the development of common clinical phenotypes, including major depressive disorder.
RESULTS NlmCategory: RESULTS
Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression. We show that major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20, and is replicated in an independent cohort of 356 unrelated case-control individuals. The twins with major depressive disorder also show increased global variation in methylation in comparison with their unaffected co-twins. ZBTB20 plays an essential role in the specification of the Cornu Ammonis-1 field identity in the developing hippocampus, a region previously implicated in the development of major depressive disorder.
CONCLUSIONS NlmCategory: CONCLUSIONS
Our results suggest that aberrant methylation profiles affecting the hippocampus are associated with major depressive disorder and show the potential of the epigenetic twin model in neuro-psychiatric disease.
DATE PUBLISHED
2014
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/11/19
accepted 2014/04/02
aheadofprint 2014/04/02
entrez 2014/04/04 06:00
pubmed 2014/04/04 06:00
medline 2014/04/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Davies MN Davies Matthew N MN
Krause L Krause Lutz L
Bell JT Bell Jordana T JT
Gao F Gao Fei F
Ward KJ Ward Kirsten J KJ
Wu H Wu Honglong H
Lu H Lu Hanlin H
Liu Y Liu Yuan Y
Tsai PC Tsai Pei-Chein PC
Collier DA Collier David A DA
Murphy T Murphy Therese T
Dempster E Dempster Emma E
Mill J Mill Jonathan J
UK Brain Expression Consortium
Battle A Battle Alexis A
Mostafavi S Mostafavi Sara S
Zhu X Zhu Xiaowei X
Henders A Henders Anjali A
Byrne E Byrne Enda E
Wray NR Wray Naomi R NR
Martin NG Martin Nicholas G NG
Spector TD Spector Tim D TD
Wang J Wang Jun J
INVESTIGATORS
JOURNAL
VOLUME: 15
ISSUE: 4
TITLE: Genome biology
ISOABBREVIATION: Genome Biol.
YEAR: 2014
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1465-6914
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Genome Biol
COUNTRY: England
ISSNLINKING: 1474-7596
NLMUNIQUEID: 100960660
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
FP7/2007-2013 Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC4072999 NLM