Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18797396
TITLE
Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression.
ABSTRACT
OBJECTIVES NlmCategory: OBJECTIVE
Association of the valine/methionine variant at codon 66 (Val66Met) of brain derived neurotrophic factor (BDNF) has been reported inconsistently across a spectrum of psychiatric disorders. Haplotypes of six tagging single nucleotide polymorphisms (SNPs) of a 37-kb region of dystrobrevin-binding protein 1 (DTNBP1) were found to be associated with schizophrenia. These haplotypes have not been studied extensively for other psychiatric disorders but are plausible candidates for anxiety and depression disorders. Here, association between variants of BDNF and DTNBP1, and multiple anxiety and depression phenotypes is explored.
METHODS NlmCategory: METHODS
Study participants were selected as sibling pairs that were either concordant or discordant for extreme neuroticism scores from a total sample of 18 742 Australian twin individuals and their siblings. All participants completed detailed Composite International Diagnostic Interview from which diagnoses of Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV depression and anxiety disorders were determined. Six hundred and seventy-four participants had a diagnosis of anxiety and/or depression from 492 families. The BDNF Val66Met and six DTNBP1 (rs3213207, rs1011313, rs2619528, rs760761, rs1018381, rs2619538) SNPs were genotyped on samples from study participants (n=2045 from 987 families) and, where possible, their parents (n=787). Family-based association tests were conducted between the individual SNPs and the DTNBP1 six SNP haplotypes and anxiety, depression, and neuroticism.
RESULTS NlmCategory: RESULTS
We found no convincing evidence for association between any of the variants studied and anxiety, depression, or neuroticism.
CONCLUSION NlmCategory: CONCLUSIONS
This study sample is relatively large but our results do not support an association between BDNF Val66Met and anxiety, depression, or neuroticisim. DTNBP1 haplotypes, which have been found to be risk factors for schizophrenia, are unlikely to be risk factors for anxiety and depression.
DATE PUBLISHED
2008 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/09/18 09:00
medline 2008/11/15 09:00
entrez 2008/09/18 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wray NR Wray Naomi R NR Queensland Institute of Medical Research, Brisbane, Australia. Naomi.Wray@qimr.edu.au
James MR James Michael R MR
Handoko HY Handoko Herlina Y HY
Dumenil T Dumenil Troy T
Lind PA Lind Penelope A PA
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 5
TITLE: Psychiatric genetics
ISOABBREVIATION: Psychiatr. Genet.
YEAR: 2008
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1473-5873
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychiatr Genet
COUNTRY: England
ISSNLINKING: 0955-8829
NLMUNIQUEID: 9106748
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Anxiety genetics
Brain-Derived Neurotrophic Factor genetics
Depression genetics
Dystrophin-Associated Proteins genetics
Gene Frequency genetics
Humans genetics
Linkage Disequilibrium genetics
Neuropeptides genetics
Neurotic Disorders genetics
Polymorphism, Single Nucleotide genetics
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Brain-Derived Neurotrophic Factor
0 DTNA protein, human
0 Dystrophin-Associated Proteins
0 Neuropeptides
OTHER ID's