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| PMID |
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| TITLE |
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| Genetic and phenotypic stability of measures of neuroticism over 22 years. |
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| ABSTRACT |
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| People meeting diagnostic criteria for anxiety or depressive disorders tend to score high on the personality scale of neuroticism. Studying this dimension of personality can therefore give insights into the etiology of important psychiatric disorders. Neuroticism can be assessed easily via self-report questionnaires in large population samples. We have examined the genetic and phenotypic stability of neuroticism, measured up to 4 times over 22 years, on different scales, on a data set of 4,999 families with over 20,000 individuals completing at least 1 neuroticism questionnaire. The neuroticism scales used were the Eysenck Personality Questionnaire revised (EPQ-R), the EPQ-R shortened form, and the NEO 5 factor inventory personality questionnaire. The estimates of heritability of the individual measures ranged from .26 +/- .04 to .36 +/- .03. Genetic, environmental, and phenotypic correlations averaged .91, .42, and .57 respectively. Despite the range in heritabilities, a more parsimonious 'repeatability model' of equal additive genetic variances and genetic correlations of unity could not be rejected. Use of multiple measures increases the effective heritability from .33 for a single measure to .43 for mean score because of the reduction in the estimate of the environmental variance, and this will increase power in genetic linkage or association studies of neuroticism. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2007/10/02 09:00 |
| medline |
2008/03/15 09:00 |
| entrez |
2007/10/02 09:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Wray NR |
|
Wray |
Naomi R |
NR |
|
Genetic Epidermology, Queensland Institute of Medical Research, Brisbane, Australia. Naomi.Wray@qimr.edu.au |
| Birley AJ |
|
Birley |
Andrew J |
AJ |
|
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| Sullivan PF |
|
Sullivan |
Patrick F |
PF |
|
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| Visscher PM |
|
Visscher |
Peter M |
PM |
|
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| Martin NG |
|
Martin |
Nicholas G |
NG |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 10 |
| ISSUE: 5 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2007 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| MH059160 |
NIMH NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Diseases in Twins |
genetics |
| Family |
genetics |
| Female |
genetics |
| Genetic Variation |
genetics |
| Genotype |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Multivariate Analysis |
genetics |
| Neurotic Disorders |
genetics |
| Phenotype |
genetics |
| Psychiatric Status Rating Scales |
genetics |
| Questionnaires |
genetics |
| Stress, Psychological |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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