Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25037970
TITLE
Applying polygenic risk scores to postpartum depression.
ABSTRACT
The etiology of major depressive disorder (MDD) is likely to be heterogeneous, but postpartum depression (PPD) is hypothesized to represent a more homogenous subset of MDD. We use genome-wide SNP data to explore this hypothesis. We assembled a total cohort of 1,420 self-report cases of PPD and 9,473 controls with genome-wide genotypes from Australia, The Netherlands, Sweden and the UK. We estimated the total variance attributable to genotyped variants. We used association results from the Psychiatric Genomics Consortia (PGC) of bipolar disorder (BPD) and MDD to create polygenic scores in PPD and related MDD data sets to estimate the genetic overlap between the disorders. We estimated that the percentage of variance on the liability scale explained by common genetic variants to be 0.22 with a standard error of 0.12, p = 0.02. The proportion of variance (R (2)) from a logistic regression of PPD case/control status in all four cohorts on a SNP profile score weighted by PGC-BPD association results was small (0.1 %) but significant (p = 0.004) indicating a genetic overlap between BPD and PPD. The results were highly significant in the Australian and Dutch cohorts (R (2) > 1.1 %, p < 0.008), where the majority of cases met criteria for MDD. The genetic overlap between BPD and MDD was not significant in larger Australian and Dutch MDD case/control cohorts after excluding PPD cases (R (2) = 0.06 %, p = 0.08), despite the larger MDD group affording more power. Our results suggest an empirical genetic evidence for a more important shared genetic etiology between BPD and PPD than between BPD and MDD.
DATE PUBLISHED
2014 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/03/24
accepted 2014/04/07
aheadofprint 2014/07/19
entrez 2014/07/20 06:00
pubmed 2014/07/20 06:00
medline 2015/06/09 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Byrne EM Byrne Enda M EM Queensland Brain Institute, The University of Queensland, Upland Road, St. Lucia, Brisbane, QLD, 4072, Australia, enda.byrne@uq.edu.au.
Carrillo-Roa T Carrillo-Roa Tania T
Penninx BW Penninx Brenda W J H BW
Sallis HM Sallis Hannah M HM
Viktorin A Viktorin Alexander A
Chapman B Chapman Brett B
Henders AK Henders Anjali K AK
Psychiatric Genomic Consortium Major Depressive Disorder Working Group
Pergadia ML Pergadia Michele L ML
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Sullivan PF Sullivan Patrick F PF
Boschloo L Boschloo Lynn L
van Grootheest G van Grootheest Gerard G
McMahon G McMahon George G
Lawlor DA Lawlor Debbie A DA
Landén M Landén Mikael M
Lichtenstein P Lichtenstein Paul P
Magnusson PK Magnusson Patrik K E PK
Evans DM Evans David M DM
Montgomery GW Montgomery Grant W GW
Boomsma DI Boomsma Dorret I DI
Martin NG Martin Nicholas G NG
Meltzer-Brody S Meltzer-Brody Samantha S
Wray NR Wray Naomi R NR
INVESTIGATORS
JOURNAL
VOLUME: 17
ISSUE: 6
TITLE: Archives of women's mental health
ISOABBREVIATION: Arch Womens Ment Health
YEAR: 2014
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1435-1102
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Arch Womens Ment Health
COUNTRY: Austria
ISSNLINKING:
NLMUNIQUEID: 9815663
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
092731 Medical Research Council United Kingdom
1RC2 MH089995 NIMH NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
DA019951 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
DK U01-066134 NIDDK NIH HHS United States
G9815508 Medical Research Council United Kingdom
K08 DA019951 NIDA NIH HHS United States
MC_UU_12013/5 Medical Research Council United Kingdom
P50 AA011998 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
RC2 MH089951 NIMH NIH HHS United States
RC2 MH089951 NIMH NIH HHS United States
RC2 MH089995 NIMH NIH HHS United States
U01 DK066134 NIDDK NIH HHS United States
U24 MH068457 NIMH NIH HHS United States
U24 MH068457-06 NIMH NIH HHS United States
WT088806 Wellcome Trust United Kingdom
WT099871MA Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Bipolar Disorder genetics
Depression, Postpartum genetics
Depressive Disorder, Major genetics
Female genetics
Genetic Predisposition to Disease genetics
Genetic Variation genetics
Genotype genetics
Humans genetics
Logistic Models genetics
Male genetics
Multifactorial Inheritance genetics
Polymorphism, Single Nucleotide genetics
Retrospective Studies genetics
Risk Factors genetics
Surveys and Questionnaires genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS614841 NLM
PMC4341990 NLM