Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19803775
TITLE
Phenotypic and discordant-monozygotic analyses of stress and perceived social support as antecedents to or sequelae of risk for depression.
ABSTRACT
The associations between social support and depression, and between stress and depression have been the subject of considerable research, and although this has included longitudinal designs, these have rarely controlled for genetic effects that mediate these associations. The sample comprised 7,356 female and 4,882 male participants aged 18-95 from the Australian NHMRC Twin Registry (ATR). Of these, between 100 and 324 female pairs and between 41 and 169 male pairs, depending on the measure, were monozygotic (MZ) pairs discordant for depression. We use the co-twin control design in combination with prospective analyses to explore the association between a composite of predictors (perceived social support, stress, and support x stress) and depression. With familial effects included, both perceived support and stress were antecedents to, and sequelae of, depression, but no stress-buffering occurred. With familial effects controlled, stress was a sequela of a prior depressive episode, and neither lack of support nor stress were antecedents to depression, though their interaction approached significance for males. The male twin who later became depressed had previously reported lower perceived support in the face of multiple stressors compared to his co-twin who did not become depressed. We show that associations commonly observed with prospective designs are partly due to familial factors.
DATE PUBLISHED
2009 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2009/10/07 06:00
pubmed 2009/10/07 06:00
medline 2010/01/23 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Coventry WL Coventry William L WL School of Behavioural, Cognitive and Social Sciences, University of New England, Armidale, Australia. coventrywill@gmail.com
Medland SE Medland Sarah E SE
Wray NR Wray Naomi R NR
Thorsteinsson EB Thorsteinsson Einar B EB
Heath AC Heath Andrew C AC
Byrne B Byrne Brian B
INVESTIGATORS
JOURNAL
VOLUME: 12
ISSUE: 5
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2009
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 AA007535 NIAAA NIH HHS United States
R01 AA007535-08 NIAAA NIH HHS United States
R01 AA010249-04 NIAAA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R37 AA007728-20 NIAAA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adaptation, Psychological
Depression psychology
Diseases in Twins psychology
Female psychology
Humans psychology
Male psychology
Phenotype psychology
Prospective Studies psychology
Psychiatric Status Rating Scales psychology
Risk Factors psychology
Social Environment psychology
Social Support psychology
Stress, Psychological complications
Twins, Monozygotic psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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