Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
20567237
TITLE
Genetic risk profiles for depression and anxiety in adult and elderly cohorts.
ABSTRACT
The first generation of genome-wide association studies (GWA studies) for psychiatric disorders has led to new insights regarding the genetic architecture of these disorders. We now start to realize that a larger number of genes, each with a small contribution, are likely to explain the heritability of psychiatric diseases. The contribution of a large number of genes to complex traits can be analyzed with genome-wide profiling. In a discovery sample, a genetic risk profile for depression was defined based on a GWA study of 1738 adult cases and 1802 controls. The genetic risk scores were tested in two population-based samples of elderly participants. The genetic risk profiles were evaluated for depression and anxiety in the Rotterdam Study cohort and the Erasmus Rucphen Family (ERF) study. The genetic risk scores were significantly associated with different measures of depression and explained up to ∼0.7% of the variance in depression in Rotterdam Study and up to ∼1% in ERF study. The genetic score for depression was also significantly associated with anxiety explaining up to 2.1% in Rotterdam study. These findings suggest the presence of many genetic loci of small effect that influence both depression and anxiety. Remarkably, the predictive value of these profiles was as large in the sample of elderly participants as in the middle-aged samples.
DATE PUBLISHED
2011 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2010/06/22
entrez 2010/06/23 06:00
pubmed 2010/06/23 06:00
medline 2011/11/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Demirkan A Demirkan A A Genetic Epidemiology Unit of the Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Penninx BW Penninx B W J H BW
Hek K Hek K K
Wray NR Wray N R NR
Amin N Amin N N
Aulchenko YS Aulchenko Y S YS
van Dyck R van Dyck R R
de Geus EJ de Geus E J C EJ
Hofman A Hofman A A
Uitterlinden AG Uitterlinden A G AG
Hottenga JJ Hottenga J-J JJ
Nolen WA Nolen W A WA
Oostra BA Oostra B A BA
Sullivan PF Sullivan P F PF
Willemsen G Willemsen G G
Zitman FG Zitman F G FG
Tiemeier H Tiemeier H H
Janssens AC Janssens A C J W AC
Boomsma DI Boomsma D I DI
van Duijn CM van Duijn C M CM
Middeldorp CM Middeldorp C M CM
INVESTIGATORS
JOURNAL
VOLUME: 16
ISSUE: 7
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2011
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
MH081802 NIMH NIH HHS United States
R01 MH059160 NIMH NIH HHS United States
R01 MH074027 NIMH NIH HHS United States
R01 MH077139 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Anxiety genetics
Cohort Studies genetics
Depression genetics
Female genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study methods
Humans methods
Male methods
Middle Aged methods
Risk Factors methods
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3142964 NLM
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