End of Talk

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Genetic Epidemiology
Related Disciplines
Some relevant human genetics
Mutation
Types of polymorphism
1 Mbp around the serotonin transporter gene (SLC6A4)
40 kbp around the serotonin transporter gene (SLC6A4)
100 bp within the serotonin transporter gene (SLC6A4)
Functional effects of variants
Recombination and haplotypes
Haplotypes and "phylogenetic" history
Population genetics
Genotype and allele frequencies
Hardy-Weinberg Equilibrium (HWE)
Testing HWE
Age of mutations
Phenotype-genotype relationships
Genetic Association Analysis
Practicalities of genotyping
Processing of samples
Technologies
Sequenom MassARRAY
Affymetrix GeneChip Mapping 100K Set
Complex Genetic Disease
What kind of groups do we study
Phenometric Studies
Relatedness of disease cases
Path analysis
Genometric Studies
Reasons to be cheerful
Causes of difficulty
Allelic Heterogeneity
Locus Heterogeneity
Low trait locus penetrances
H1H1 vs H1H2+H2H2
Between-population marker heterogeneity
Gene by Environment Interaction
Mendelian Randomization
The serotonin transporter gene (SLC6A4) promoter polymorphism
SLC6A4 promoter polymorphism and behaviour
SLC6A4 promoter polymorphism and behaviour 2
Caspi et al [2003]
Genotyping in Caspi et al [2003]
Life Events in Caspi et al [2003]
Childhood maltreatment in Caspi et al [2003]
Depression in Caspi et al [2003]
Results from Caspi et al [2003]
Results from Caspi et al [2003] 2
Replications
Population genetics of SLC6A4 promotor polymorphism