Phenometric Studies

• "General" population samples eg degree of relatedness of pairs of cancer cases compared to that of pairs of controls eg prostate cancer in Utah (expressed as mean coefficient of relationship so clustering in terms of genetic distance); all cancers and sharing surnames in UK.
• Weinberg proband-control studies eg CASH study of breast cancer, Cooke's studies of asthma.
• Path analysis of family material eg Tambs on hypertension
• Twin studies
• Segregation analysis of family material eg Morton on total sIgE