Heritability of Prolapse / Pelvic Floor Study
Study Code:PF
Sample:Female Twins aged 18-25 years and their female siblings
Start Date:Mar.2002
Status:In progress
Contact:Margie Wright
More Info:QIMR only

Introduction and Aims

This project aims to assess the contributions of genes and environment to female pelvic organ prolapse and stress incontinence of urine. A comparison of mono- and dizygotic twins is thought to be the most suitable method to investigate heritability. It is therefore intended to perform phenotype assessment on nulliparous female twins. Once heritability of this trait has been demonstrated and quantified, linkage studies will be required to determine candidate genes. A genomic screen (ABI Prism Linkage Mapping Set Version 2 (PE Applied Biosystems) with 400 markers at ~10 cM coverage) has been performed on these twins and is available for future linkage analysis at QIMR. In the medium term such work should result in the identification of target genes and polymorphisms/ mutation in these genes that would confer a heightened risk for the development of the phenotypic abnormality. Accurate risk assessment should hopefully lead to better targeting of preventative measures and better obstetric management, reducing the significant morbidity and healthcare costs arising from pelvic organ prolapse and incontinence. The Twin Adolescent (TA) Study is investigating the "Genetics of Laterality, Health and Wellbeing, Personality, Smell Sensitivity, Taste Sensitivity and Reading".


Professor Nick Martin, QIMR

Dr Hans Peter Dietz, MD (Heidelberg), FRANZCOG, DDU
Urogynaecology/ Research Fellow,
Royal Hospital for Women, Randwick NSW


Prof. S.K. Khoo, Professor of Obstetrics and Gynaecology
Extensive experience in the supervision of clinical research in Gynaecology.

Barton Clarke M.MSc.(Urogyn) FRCSE, FRACS, FRCOG, FRANZCOG
Director of Urogynaecology Royal Women's Hospital, Herston QLD