The Candidate Gene Study - (IRPG1)
Study Code:CG
Sample:Twins and twins' biological family ie siblings and parents. Spouses of twins and spouses' biological family ie siblings and parents.
Start Date:Jan.2003
Status:In progress
Contact:Anjali Henders
More Info:QIMR only


Brief description of the Project:

This is the first project (in a group of 3) which form an Interactive Research Project Grant (IRPG). The IRPG mechanism was developed by NIH out of recognition of (a) the need to reconcile congressional mandates for large numbers of research projects to be funded, and (b) the need for complex large budget projects requiring multiple teams of investigators. Each IRPG project component must be feasible if it alone is funded, but with the expectation that the whole will be more than the sum of the parts. Our projects are identical in terms of the protocols, the procedures, the subjects and the genetic work. They differ only in their experimental design. IRPG 1 uses an unmatched case-control design; IRPG 2 uses a "big-sibship" design (families that have 5 or more siblings); IRPG 3 uses an EDAC design (families that are extremely discordant or concordant). These projects aim to use combined candidate gene association and quantitative trait locus (QTL) linkage approaches to map genes contributing to heavy drinking and alcohol dependence risk.