!
! Episodic Ataxia/Myokymia pedigrees from Litt et al AJHG 1994; 55: 702-9
! used as an example for APM mapping by Davis et al. AJHG 1996; 58: 867-80
! 10 C 13 markers
! pter--S91 S100 CACNL1A1 S372 S99 pY2/1 pY21/1 KCNA5 S93--cen
!          1.0  1.0     3.0 ------ 3.0 ------ 1.0   1.0
!
! multipoint LOD score analysis gives Zmax=11.35 between D12S99 and KCNA5
!
set impute on
set datadir ../pedigrees
set locus ep_ataxia aff
set locus S91 nam
set locus S100 nam
set locus CACNL1A1 nam
set locus S372 nam
set locus S99 nam
set locus pY2/1 nam
set locus pY21/1 nam
set locus KCNA5 nam
set locus S93 nam
read pedigree ataxia.ped
run
set ple 1
set iter 5000
dis S91 S100
bye
apm ep_ataxia ibd
tdt ep_ataxia
assoc ep_ataxia
sibpair ep_ataxia 
