!
! Genetic linkage evidence for a familial Alzheimer's disease locus on
! Chromosome 14.  Schellenberg GD, Bird TD, Wijsman E, Harry T, Anderson L,
! Nemens E et al.  Science 1992; 258: 668-671
!
! Three Volga German families taken from Figure 1 out of 14 described.
! Note these are altered to protect confidentiality and sexes were not shown.
! Genotypes at three markers are given, along with Z at r=0 (Zmax):
!
!                   .207          .025
! Family    D14S52 ------ D14S43 ------ D14S53
! AM       -2.70 (.08)    0.00 (.02)    1.49
! L         1.82          4.89         -4.57 (2.44 at r=0.05)
! SNW       0.87          2.17          0.66
!       
! Genehunter at D14S43 gave:
!      NPL    p-value
!  AM  0.3504 0.23047
!   L  0.6947 0.10021
! SNW  0.4554 0.02948
!
!
set mincount 50
set iter 50
set data ../pedigrees
set locus AD aff
set locus onset qua
set locus age qua
set locus D14S52 mar
set locus D14S43 mar
set locus D14S53 mar
set locus proband aff
rea ped volga.ped
run
ass AD 
ass proband
