!
! Genetic linkage evidence for a familial Alzheimer's disease locus on
! Chromosome 14.  Schellenberg GD, Bird TD, Wijsman E, Harry T, Anderson L,
! Nemens E et al.  Science 1992; 258: 668-671
!
! Three Volga German families taken from Figure 1 out of 14 described.
! Note these are altered to protect confidentiality and sexes were not shown.
! Genotypes at three markers are given, along with Z at r=0 (Zmax):
!
!                   .207          .025
! Family    D14S52 ------ D14S43 ------ D14S53
! AM       -2.70 (.08)    0.00 (.02)    1.49
! L         1.82          4.89         -4.57 (2.44 at r=0.05)
! SNW       0.87          2.17          0.66
!       
! Genehunter at D14S43 gave:
!      NPL    p-value
!  AM  0.3504 0.23047
!   L  0.6947 0.10021
! SNW  0.4554 0.02948
!
!
set mincount 50
set iter 5000
set data ../pedigrees
set locus AD aff
set locus onset qua
set locus age qua
set locus D14S52 mar
set locus D14S43 mar
set locus D14S53 mar
set locus proband aff
rea ped volga.ped
run
wri
dis
bye
lin
kap onset AD res
des onset
var onset
sib onset
qtl onset
bye
keep AD D14S43
set ple 2
set iter 0
tdt AD
bye
nuclear
write pedigree x.xxx
bye
kap onset AD res
! desc onset
! ass onset 
set ple 1
asp AD
sib onset sim
bye
nuclear
all onset anova
sib AD
freq AD
davie AD proband
davie AD
assoc AD
apm AD
apm AD ibd
