!
! Psoriasis families from Matthews et al Nat Genet 1996; 14: 231-3
! 8 chromosome 4q markers from genome scan.
!
! Previous linkage to 17q was not replicable in these families
! (a single family with LOD of 1.2 for D17S795 is excluded)
!
! Best 2-point LOD is 3.0 (th=0.08) for D4S1535 using
!   P(D)=0.0133 Pen(DD)=Pen(Dd)=0.7 Pen(dd)=0.05
! For D4S408, LOD=2.6 (th=0.10), for D4S1540, LOD=2.8 (th=0.07), 
! for D4S171, LOD=1.1 (th=0.17), for D4S1652, LOD=2.8 (th=0.13) 
!
! Genehunter gave a NPLmax close to D4S1540 (P=0.0026)
!
! Map used:
! Mar: D4S2920 D4S1554 D4S1535 D4S408 D4S1540 D4S171 D4S2921 D4S1652 -- tel
! Th :      0.02    0.03     0.01   0.04    0.005  0.065   0.01
!
set data ../pedigrees
set locus psor aff
set locus D4S2920 mar
set locus D4S1554 mar
set locus D4S1535 mar
set locus D4S408 mar
set locus D4S1540 mar
set locus D4S171 mar
set locus D4S2921 mar
set locus D4S1652 mar
read pedigree psoriasis.ped
run
freq
tdt psor
assoc psor
sibpair psor 
asp psor
apm psor ibd
! wri lin psor.pre
! wri loc lin psor.loc

