# # Per-litter data from teratogenicity study of boric acid # Reproduced in Slaton SL, Piegorsch WW, Durham SD (2000). # Estimation and Testing with Overdispersed Proportions Using the # Beta-Logistic Regression Model of Heckman and Willis # Biometrics 56:125-133 # # Originally appeared in: # National Toxicology Program (1989). Developmental toxicity of # boric acid (CAS No. 10043-35-3) administered to CS-1 Swiss mice. # Technical Report NTP-89-250, US National Toxicology Program, # Research Triangle Park, North Carolina. # # dose = 0 dose = 0.1 dose = 0.2 dose = 0.4 # Nonvia Implants Nonvia Implants Nonvia Implants Nonvia Implants # 0 15 0 6 1 12 12 12 # 0 3 1 14 0 12 1 12 # 1 9 1 12 0 11 0 13 # 1 12 0 10 0 13 2 8 # 1 13 2 14 0 12 2 12 # 2 13 0 12 0 14 4 13 # 0 16 0 14 4 15 0 13 # 0 11 3 14 0 14 1 13 # 1 11 0 10 0 12 0 12 # 2 8 2 12 1 6 1 9 # 0 14 3 13 2 13 3 9 # 0 13 1 11 0 10 0 11 # 3 14 1 11 1 14 1 14 # 1 13 0 11 1 12 0 10 # 0 8 0 13 0 10 3 12 # 0 13 0 10 0 9 2 21 # 2 14 1 12 1 12 3 10 # 3 14 0 11 0 13 3 11 # 0 11 2 10 1 14 1 11 # 2 12 2 12 0 13 1 11 # 0 15 2 15 0 14 8 14 # 0 15 3 12 1 13 0 15 # 2 14 1 12 2 12 2 13 # 1 11 0 12 1 14 8 11 # 1 16 1 12 0 13 4 12 # 0 12 1 13 0 12 2 12 # 0 14 1 15 1 7 0 0 # # AIC BIC logLik deviance # y ~ dose + (1 | litter) + (1 | dose.group) 787.0702 807.7415 -389.5351 779.0702 # y ~ dose + (1 | litter) 785.1210 800.6244 -389.5605 779.1210 # y ~ 1 + (1 | litter) 793.9393 804.2749 -394.9697 789.9393 # Random effects: # Groups Name Variance Std.Dev. # litter (Intercept) 1.027175 1.01350 # dose.group (Intercept) 0.016316 0.12773 # Fixed effects: # Estimate Std. Error z value Pr(>|z|) # (Intercept) -3.19864 0.25956 -12.3234 < 2.2e-16 *** # dose 3.26470 1.05148 3.1049 0.001904 ** # # Generalized linear mixed model fit using Laplace # Formula: y ~ dose + (1 | litter) # Data: x # Family: binomial(logit link) # AIC BIC logLik deviance # 785.121 800.6244 -389.5605 779.121 # Random effects: # Groups Name Variance Std.Dev. # litter (Intercept) 1.0583 1.0287 # # of obs: 1297, groups: litter, 107 # # Estimated scale (compare to 1) 0.8398359 # # Fixed effects: # Estimate Std. Error z value Pr(>|z|) # (Intercept) -3.20829 0.24362 -13.1693 < 2.2e-16 *** # dose 3.29906 0.97237 3.3928 0.0006918 *** # # The thrust of the Slaton et al paper is that there are significant # differences in the sibship binary correlation across the 4 dosage # levels (mainly the highest dose). This means a traditional beta-binomial # model (assuming no GxE) would be inappropriate. # # Dose Litters N Nonviable i-c r Tarone Chi-square Variance Chisq # 0 28 334 0.069 0.17 0.51 31.3 # 0.1 28 323 0.087 0.13 0.04 25.35 # 0.2 28 326 0.052 0.23 1.71 33.83 # 0.4 27 314 0.204 0.36 140.81 108.25 # # Total 108 1297 0.102 0.19 189.59 303.68 # # A homogeneity chi-square based on the Tarone score tests would be # 189.59-(0.51+0.04+1.71+140.59) = 46.52 (3 df) # or on the variance test (conventional analysis of 2 x 108 contingency table) # 303.68-(108.25+33.83+25.35+31.30) = 104.95 (3 df) # set loc nonviable aff set loc dose qua read pedigree inline dose0 1 fa.1 mo.1 x n 0 dose0 2 fa.1 mo.1 x n 0 dose0 3 fa.1 mo.1 x n 0 dose0 4 fa.1 mo.1 x n 0 dose0 5 fa.1 mo.1 x n 0 dose0 6 fa.1 mo.1 x n 0 dose0 7 fa.1 mo.1 x n 0 dose0 8 fa.1 mo.1 x n 0 dose0 9 fa.1 mo.1 x n 0 dose0 10 fa.1 mo.1 x n 0 dose0 11 fa.1 mo.1 x n 0 dose0 12 fa.1 mo.1 x n 0 dose0 13 fa.1 mo.1 x n 0 dose0 14 fa.1 mo.1 x n 0 dose0 15 fa.1 mo.1 x n 0 dose0 16 fa.5 mo.5 x n 0 dose0 17 fa.5 mo.5 x n 0 dose0 18 fa.5 mo.5 x n 0 dose0 19 fa.9 mo.9 x y 0 dose0 20 fa.9 mo.9 x n 0 dose0 21 fa.9 mo.9 x n 0 dose0 22 fa.9 mo.9 x n 0 dose0 23 fa.9 mo.9 x n 0 dose0 24 fa.9 mo.9 x n 0 dose0 25 fa.9 mo.9 x n 0 dose0 26 fa.9 mo.9 x n 0 dose0 27 fa.9 mo.9 x n 0 dose0 28 fa.13 mo.13 x y 0 dose0 29 fa.13 mo.13 x n 0 dose0 30 fa.13 mo.13 x n 0 dose0 31 fa.13 mo.13 x n 0 dose0 32 fa.13 mo.13 x n 0 dose0 33 fa.13 mo.13 x n 0 dose0 34 fa.13 mo.13 x n 0 dose0 35 fa.13 mo.13 x n 0 dose0 36 fa.13 mo.13 x n 0 dose0 37 fa.13 mo.13 x n 0 dose0 38 fa.13 mo.13 x n 0 dose0 39 fa.13 mo.13 x n 0 dose0 40 fa.17 mo.17 x y 0 dose0 41 fa.17 mo.17 x n 0 dose0 42 fa.17 mo.17 x n 0 dose0 43 fa.17 mo.17 x n 0 dose0 44 fa.17 mo.17 x n 0 dose0 45 fa.17 mo.17 x n 0 dose0 46 fa.17 mo.17 x n 0 dose0 47 fa.17 mo.17 x n 0 dose0 48 fa.17 mo.17 x n 0 dose0 49 fa.17 mo.17 x n 0 dose0 50 fa.17 mo.17 x n 0 dose0 51 fa.17 mo.17 x n 0 dose0 52 fa.17 mo.17 x n 0 dose0 53 fa.21 mo.21 x y 0 dose0 54 fa.21 mo.21 x y 0 dose0 55 fa.21 mo.21 x n 0 dose0 56 fa.21 mo.21 x n 0 dose0 57 fa.21 mo.21 x n 0 dose0 58 fa.21 mo.21 x n 0 dose0 59 fa.21 mo.21 x n 0 dose0 60 fa.21 mo.21 x n 0 dose0 61 fa.21 mo.21 x n 0 dose0 62 fa.21 mo.21 x n 0 dose0 63 fa.21 mo.21 x n 0 dose0 64 fa.21 mo.21 x n 0 dose0 65 fa.21 mo.21 x n 0 dose0 66 fa.25 mo.25 x n 0 dose0 67 fa.25 mo.25 x n 0 dose0 68 fa.25 mo.25 x n 0 dose0 69 fa.25 mo.25 x n 0 dose0 70 fa.25 mo.25 x n 0 dose0 71 fa.25 mo.25 x n 0 dose0 72 fa.25 mo.25 x n 0 dose0 73 fa.25 mo.25 x n 0 dose0 74 fa.25 mo.25 x n 0 dose0 75 fa.25 mo.25 x n 0 dose0 76 fa.25 mo.25 x n 0 dose0 77 fa.25 mo.25 x n 0 dose0 78 fa.25 mo.25 x n 0 dose0 79 fa.25 mo.25 x n 0 dose0 80 fa.25 mo.25 x n 0 dose0 81 fa.25 mo.25 x n 0 dose0 82 fa.29 mo.29 x n 0 dose0 83 fa.29 mo.29 x n 0 dose0 84 fa.29 mo.29 x n 0 dose0 85 fa.29 mo.29 x n 0 dose0 86 fa.29 mo.29 x n 0 dose0 87 fa.29 mo.29 x n 0 dose0 88 fa.29 mo.29 x n 0 dose0 89 fa.29 mo.29 x n 0 dose0 90 fa.29 mo.29 x n 0 dose0 91 fa.29 mo.29 x n 0 dose0 92 fa.29 mo.29 x n 0 dose0 93 fa.33 mo.33 x y 0 dose0 94 fa.33 mo.33 x n 0 dose0 95 fa.33 mo.33 x n 0 dose0 96 fa.33 mo.33 x n 0 dose0 97 fa.33 mo.33 x n 0 dose0 98 fa.33 mo.33 x n 0 dose0 99 fa.33 mo.33 x n 0 dose0 100 fa.33 mo.33 x n 0 dose0 101 fa.33 mo.33 x n 0 dose0 102 fa.33 mo.33 x n 0 dose0 103 fa.33 mo.33 x n 0 dose0 104 fa.37 mo.37 x y 0 dose0 105 fa.37 mo.37 x y 0 dose0 106 fa.37 mo.37 x n 0 dose0 107 fa.37 mo.37 x n 0 dose0 108 fa.37 mo.37 x n 0 dose0 109 fa.37 mo.37 x n 0 dose0 110 fa.37 mo.37 x n 0 dose0 111 fa.37 mo.37 x n 0 dose0 112 fa.41 mo.41 x n 0 dose0 113 fa.41 mo.41 x n 0 dose0 114 fa.41 mo.41 x n 0 dose0 115 fa.41 mo.41 x n 0 dose0 116 fa.41 mo.41 x n 0 dose0 117 fa.41 mo.41 x n 0 dose0 118 fa.41 mo.41 x n 0 dose0 119 fa.41 mo.41 x n 0 dose0 120 fa.41 mo.41 x n 0 dose0 121 fa.41 mo.41 x n 0 dose0 122 fa.41 mo.41 x n 0 dose0 123 fa.41 mo.41 x n 0 dose0 124 fa.41 mo.41 x n 0 dose0 125 fa.41 mo.41 x n 0 dose0 126 fa.45 mo.45 x n 0 dose0 127 fa.45 mo.45 x n 0 dose0 128 fa.45 mo.45 x n 0 dose0 129 fa.45 mo.45 x n 0 dose0 130 fa.45 mo.45 x n 0 dose0 131 fa.45 mo.45 x n 0 dose0 132 fa.45 mo.45 x n 0 dose0 133 fa.45 mo.45 x n 0 dose0 134 fa.45 mo.45 x n 0 dose0 135 fa.45 mo.45 x n 0 dose0 136 fa.45 mo.45 x n 0 dose0 137 fa.45 mo.45 x n 0 dose0 138 fa.45 mo.45 x n 0 dose0 139 fa.49 mo.49 x y 0 dose0 140 fa.49 mo.49 x y 0 dose0 141 fa.49 mo.49 x y 0 dose0 142 fa.49 mo.49 x n 0 dose0 143 fa.49 mo.49 x n 0 dose0 144 fa.49 mo.49 x n 0 dose0 145 fa.49 mo.49 x n 0 dose0 146 fa.49 mo.49 x n 0 dose0 147 fa.49 mo.49 x n 0 dose0 148 fa.49 mo.49 x n 0 dose0 149 fa.49 mo.49 x n 0 dose0 150 fa.49 mo.49 x n 0 dose0 151 fa.49 mo.49 x n 0 dose0 152 fa.49 mo.49 x n 0 dose0 153 fa.53 mo.53 x y 0 dose0 154 fa.53 mo.53 x n 0 dose0 155 fa.53 mo.53 x n 0 dose0 156 fa.53 mo.53 x n 0 dose0 157 fa.53 mo.53 x n 0 dose0 158 fa.53 mo.53 x n 0 dose0 159 fa.53 mo.53 x n 0 dose0 160 fa.53 mo.53 x n 0 dose0 161 fa.53 mo.53 x n 0 dose0 162 fa.53 mo.53 x n 0 dose0 163 fa.53 mo.53 x n 0 dose0 164 fa.53 mo.53 x n 0 dose0 165 fa.53 mo.53 x n 0 dose0 166 fa.57 mo.57 x n 0 dose0 167 fa.57 mo.57 x n 0 dose0 168 fa.57 mo.57 x n 0 dose0 169 fa.57 mo.57 x n 0 dose0 170 fa.57 mo.57 x n 0 dose0 171 fa.57 mo.57 x n 0 dose0 172 fa.57 mo.57 x n 0 dose0 173 fa.57 mo.57 x n 0 dose0 174 fa.61 mo.61 x n 0 dose0 175 fa.61 mo.61 x n 0 dose0 176 fa.61 mo.61 x n 0 dose0 177 fa.61 mo.61 x n 0 dose0 178 fa.61 mo.61 x n 0 dose0 179 fa.61 mo.61 x n 0 dose0 180 fa.61 mo.61 x n 0 dose0 181 fa.61 mo.61 x n 0 dose0 182 fa.61 mo.61 x n 0 dose0 183 fa.61 mo.61 x n 0 dose0 184 fa.61 mo.61 x n 0 dose0 185 fa.61 mo.61 x n 0 dose0 186 fa.61 mo.61 x n 0 dose0 187 fa.65 mo.65 x y 0 dose0 188 fa.65 mo.65 x y 0 dose0 189 fa.65 mo.65 x n 0 dose0 190 fa.65 mo.65 x n 0 dose0 191 fa.65 mo.65 x n 0 dose0 192 fa.65 mo.65 x n 0 dose0 193 fa.65 mo.65 x n 0 dose0 194 fa.65 mo.65 x n 0 dose0 195 fa.65 mo.65 x n 0 dose0 196 fa.65 mo.65 x n 0 dose0 197 fa.65 mo.65 x n 0 dose0 198 fa.65 mo.65 x n 0 dose0 199 fa.65 mo.65 x n 0 dose0 200 fa.65 mo.65 x n 0 dose0 201 fa.69 mo.69 x y 0 dose0 202 fa.69 mo.69 x y 0 dose0 203 fa.69 mo.69 x y 0 dose0 204 fa.69 mo.69 x n 0 dose0 205 fa.69 mo.69 x n 0 dose0 206 fa.69 mo.69 x n 0 dose0 207 fa.69 mo.69 x n 0 dose0 208 fa.69 mo.69 x n 0 dose0 209 fa.69 mo.69 x n 0 dose0 210 fa.69 mo.69 x n 0 dose0 211 fa.69 mo.69 x n 0 dose0 212 fa.69 mo.69 x n 0 dose0 213 fa.69 mo.69 x n 0 dose0 214 fa.69 mo.69 x n 0 dose0 215 fa.73 mo.73 x n 0 dose0 216 fa.73 mo.73 x n 0 dose0 217 fa.73 mo.73 x n 0 dose0 218 fa.73 mo.73 x n 0 dose0 219 fa.73 mo.73 x n 0 dose0 220 fa.73 mo.73 x n 0 dose0 221 fa.73 mo.73 x n 0 dose0 222 fa.73 mo.73 x n 0 dose0 223 fa.73 mo.73 x n 0 dose0 224 fa.73 mo.73 x n 0 dose0 225 fa.73 mo.73 x n 0 dose0 226 fa.77 mo.77 x y 0 dose0 227 fa.77 mo.77 x y 0 dose0 228 fa.77 mo.77 x n 0 dose0 229 fa.77 mo.77 x n 0 dose0 230 fa.77 mo.77 x n 0 dose0 231 fa.77 mo.77 x n 0 dose0 232 fa.77 mo.77 x n 0 dose0 233 fa.77 mo.77 x n 0 dose0 234 fa.77 mo.77 x n 0 dose0 235 fa.77 mo.77 x n 0 dose0 236 fa.77 mo.77 x n 0 dose0 237 fa.77 mo.77 x n 0 dose0 238 fa.81 mo.81 x n 0 dose0 239 fa.81 mo.81 x n 0 dose0 240 fa.81 mo.81 x n 0 dose0 241 fa.81 mo.81 x n 0 dose0 242 fa.81 mo.81 x n 0 dose0 243 fa.81 mo.81 x n 0 dose0 244 fa.81 mo.81 x n 0 dose0 245 fa.81 mo.81 x n 0 dose0 246 fa.81 mo.81 x n 0 dose0 247 fa.81 mo.81 x n 0 dose0 248 fa.81 mo.81 x n 0 dose0 249 fa.81 mo.81 x n 0 dose0 250 fa.81 mo.81 x n 0 dose0 251 fa.81 mo.81 x n 0 dose0 252 fa.81 mo.81 x n 0 dose0 253 fa.85 mo.85 x n 0 dose0 254 fa.85 mo.85 x n 0 dose0 255 fa.85 mo.85 x n 0 dose0 256 fa.85 mo.85 x n 0 dose0 257 fa.85 mo.85 x n 0 dose0 258 fa.85 mo.85 x n 0 dose0 259 fa.85 mo.85 x n 0 dose0 260 fa.85 mo.85 x n 0 dose0 261 fa.85 mo.85 x n 0 dose0 262 fa.85 mo.85 x n 0 dose0 263 fa.85 mo.85 x n 0 dose0 264 fa.85 mo.85 x n 0 dose0 265 fa.85 mo.85 x n 0 dose0 266 fa.85 mo.85 x n 0 dose0 267 fa.85 mo.85 x n 0 dose0 268 fa.89 mo.89 x y 0 dose0 269 fa.89 mo.89 x y 0 dose0 270 fa.89 mo.89 x n 0 dose0 271 fa.89 mo.89 x n 0 dose0 272 fa.89 mo.89 x n 0 dose0 273 fa.89 mo.89 x n 0 dose0 274 fa.89 mo.89 x n 0 dose0 275 fa.89 mo.89 x n 0 dose0 276 fa.89 mo.89 x n 0 dose0 277 fa.89 mo.89 x n 0 dose0 278 fa.89 mo.89 x n 0 dose0 279 fa.89 mo.89 x n 0 dose0 280 fa.89 mo.89 x n 0 dose0 281 fa.89 mo.89 x n 0 dose0 282 fa.93 mo.93 x y 0 dose0 283 fa.93 mo.93 x n 0 dose0 284 fa.93 mo.93 x n 0 dose0 285 fa.93 mo.93 x n 0 dose0 286 fa.93 mo.93 x n 0 dose0 287 fa.93 mo.93 x n 0 dose0 288 fa.93 mo.93 x n 0 dose0 289 fa.93 mo.93 x n 0 dose0 290 fa.93 mo.93 x n 0 dose0 291 fa.93 mo.93 x n 0 dose0 292 fa.93 mo.93 x n 0 dose0 293 fa.97 mo.97 x y 0 dose0 294 fa.97 mo.97 x n 0 dose0 295 fa.97 mo.97 x n 0 dose0 296 fa.97 mo.97 x n 0 dose0 297 fa.97 mo.97 x n 0 dose0 298 fa.97 mo.97 x n 0 dose0 299 fa.97 mo.97 x n 0 dose0 300 fa.97 mo.97 x n 0 dose0 301 fa.97 mo.97 x n 0 dose0 302 fa.97 mo.97 x n 0 dose0 303 fa.97 mo.97 x n 0 dose0 304 fa.97 mo.97 x n 0 dose0 305 fa.97 mo.97 x n 0 dose0 306 fa.97 mo.97 x n 0 dose0 307 fa.97 mo.97 x n 0 dose0 308 fa.97 mo.97 x n 0 dose0 309 fa.101 mo.101 x n 0 dose0 310 fa.101 mo.101 x n 0 dose0 311 fa.101 mo.101 x n 0 dose0 312 fa.101 mo.101 x n 0 dose0 313 fa.101 mo.101 x n 0 dose0 314 fa.101 mo.101 x n 0 dose0 315 fa.101 mo.101 x n 0 dose0 316 fa.101 mo.101 x n 0 dose0 317 fa.101 mo.101 x n 0 dose0 318 fa.101 mo.101 x n 0 dose0 319 fa.101 mo.101 x n 0 dose0 320 fa.101 mo.101 x n 0 dose0 321 fa.105 mo.105 x n 0 dose0 322 fa.105 mo.105 x n 0 dose0 323 fa.105 mo.105 x n 0 dose0 324 fa.105 mo.105 x n 0 dose0 325 fa.105 mo.105 x n 0 dose0 326 fa.105 mo.105 x n 0 dose0 327 fa.105 mo.105 x n 0 dose0 328 fa.105 mo.105 x n 0 dose0 329 fa.105 mo.105 x n 0 dose0 330 fa.105 mo.105 x n 0 dose0 331 fa.105 mo.105 x n 0 dose0 332 fa.105 mo.105 x n 0 dose0 333 fa.105 mo.105 x n 0 dose0 334 fa.105 mo.105 x n 0 dose1 335 fa.2 mo.2 x n 0.1 dose1 336 fa.2 mo.2 x n 0.1 dose1 337 fa.2 mo.2 x n 0.1 dose1 338 fa.2 mo.2 x n 0.1 dose1 339 fa.2 mo.2 x n 0.1 dose1 340 fa.2 mo.2 x n 0.1 dose1 341 fa.6 mo.6 x y 0.1 dose1 342 fa.6 mo.6 x n 0.1 dose1 343 fa.6 mo.6 x n 0.1 dose1 344 fa.6 mo.6 x n 0.1 dose1 345 fa.6 mo.6 x n 0.1 dose1 346 fa.6 mo.6 x n 0.1 dose1 347 fa.6 mo.6 x n 0.1 dose1 348 fa.6 mo.6 x n 0.1 dose1 349 fa.6 mo.6 x n 0.1 dose1 350 fa.6 mo.6 x n 0.1 dose1 351 fa.6 mo.6 x n 0.1 dose1 352 fa.6 mo.6 x n 0.1 dose1 353 fa.6 mo.6 x n 0.1 dose1 354 fa.6 mo.6 x n 0.1 dose1 355 fa.10 mo.10 x n 0.1 dose1 356 fa.10 mo.10 x n 0.1 dose1 357 fa.10 mo.10 x n 0.1 dose1 358 fa.10 mo.10 x n 0.1 dose1 359 fa.10 mo.10 x n 0.1 dose1 360 fa.10 mo.10 x n 0.1 dose1 361 fa.10 mo.10 x n 0.1 dose1 362 fa.10 mo.10 x n 0.1 dose1 363 fa.10 mo.10 x y 0.1 dose1 364 fa.10 mo.10 x n 0.1 dose1 365 fa.10 mo.10 x n 0.1 dose1 366 fa.10 mo.10 x n 0.1 dose1 367 fa.14 mo.14 x n 0.1 dose1 368 fa.14 mo.14 x n 0.1 dose1 369 fa.14 mo.14 x n 0.1 dose1 370 fa.14 mo.14 x n 0.1 dose1 371 fa.14 mo.14 x n 0.1 dose1 372 fa.14 mo.14 x n 0.1 dose1 373 fa.14 mo.14 x n 0.1 dose1 374 fa.14 mo.14 x n 0.1 dose1 375 fa.14 mo.14 x n 0.1 dose1 376 fa.14 mo.14 x n 0.1 dose1 377 fa.18 mo.18 x y 0.1 dose1 378 fa.18 mo.18 x y 0.1 dose1 379 fa.18 mo.18 x n 0.1 dose1 380 fa.18 mo.18 x n 0.1 dose1 381 fa.18 mo.18 x n 0.1 dose1 382 fa.18 mo.18 x n 0.1 dose1 383 fa.18 mo.18 x n 0.1 dose1 384 fa.18 mo.18 x n 0.1 dose1 385 fa.18 mo.18 x n 0.1 dose1 386 fa.18 mo.18 x n 0.1 dose1 387 fa.18 mo.18 x n 0.1 dose1 388 fa.18 mo.18 x n 0.1 dose1 389 fa.18 mo.18 x n 0.1 dose1 390 fa.18 mo.18 x n 0.1 dose1 391 fa.22 mo.22 x n 0.1 dose1 392 fa.22 mo.22 x n 0.1 dose1 393 fa.22 mo.22 x n 0.1 dose1 394 fa.22 mo.22 x n 0.1 dose1 395 fa.22 mo.22 x n 0.1 dose1 396 fa.22 mo.22 x n 0.1 dose1 397 fa.22 mo.22 x n 0.1 dose1 398 fa.22 mo.22 x n 0.1 dose1 399 fa.22 mo.22 x n 0.1 dose1 400 fa.22 mo.22 x n 0.1 dose1 401 fa.22 mo.22 x n 0.1 dose1 402 fa.22 mo.22 x n 0.1 dose1 403 fa.26 mo.26 x n 0.1 dose1 404 fa.26 mo.26 x n 0.1 dose1 405 fa.26 mo.26 x n 0.1 dose1 406 fa.26 mo.26 x n 0.1 dose1 407 fa.26 mo.26 x n 0.1 dose1 408 fa.26 mo.26 x n 0.1 dose1 409 fa.26 mo.26 x n 0.1 dose1 410 fa.26 mo.26 x n 0.1 dose1 411 fa.26 mo.26 x n 0.1 dose1 412 fa.26 mo.26 x n 0.1 dose1 413 fa.26 mo.26 x n 0.1 dose1 414 fa.26 mo.26 x n 0.1 dose1 415 fa.26 mo.26 x n 0.1 dose1 416 fa.26 mo.26 x n 0.1 dose1 417 fa.30 mo.30 x y 0.1 dose1 418 fa.30 mo.30 x y 0.1 dose1 419 fa.30 mo.30 x y 0.1 dose1 420 fa.30 mo.30 x n 0.1 dose1 421 fa.30 mo.30 x n 0.1 dose1 422 fa.30 mo.30 x n 0.1 dose1 423 fa.30 mo.30 x n 0.1 dose1 424 fa.30 mo.30 x n 0.1 dose1 425 fa.30 mo.30 x n 0.1 dose1 426 fa.30 mo.30 x n 0.1 dose1 427 fa.30 mo.30 x n 0.1 dose1 428 fa.30 mo.30 x n 0.1 dose1 429 fa.30 mo.30 x n 0.1 dose1 430 fa.30 mo.30 x n 0.1 dose1 431 fa.34 mo.34 x n 0.1 dose1 432 fa.34 mo.34 x n 0.1 dose1 433 fa.34 mo.34 x n 0.1 dose1 434 fa.34 mo.34 x n 0.1 dose1 435 fa.34 mo.34 x n 0.1 dose1 436 fa.34 mo.34 x n 0.1 dose1 437 fa.34 mo.34 x n 0.1 dose1 438 fa.34 mo.34 x n 0.1 dose1 439 fa.34 mo.34 x n 0.1 dose1 440 fa.34 mo.34 x n 0.1 dose1 441 fa.38 mo.38 x y 0.1 dose1 442 fa.38 mo.38 x y 0.1 dose1 443 fa.38 mo.38 x n 0.1 dose1 444 fa.38 mo.38 x n 0.1 dose1 445 fa.38 mo.38 x n 0.1 dose1 446 fa.38 mo.38 x n 0.1 dose1 447 fa.38 mo.38 x n 0.1 dose1 448 fa.38 mo.38 x n 0.1 dose1 449 fa.38 mo.38 x n 0.1 dose1 450 fa.38 mo.38 x n 0.1 dose1 451 fa.38 mo.38 x n 0.1 dose1 452 fa.38 mo.38 x n 0.1 dose1 453 fa.42 mo.42 x y 0.1 dose1 454 fa.42 mo.42 x y 0.1 dose1 455 fa.42 mo.42 x y 0.1 dose1 456 fa.42 mo.42 x n 0.1 dose1 457 fa.42 mo.42 x n 0.1 dose1 458 fa.42 mo.42 x n 0.1 dose1 459 fa.42 mo.42 x n 0.1 dose1 460 fa.42 mo.42 x n 0.1 dose1 461 fa.42 mo.42 x n 0.1 dose1 462 fa.42 mo.42 x n 0.1 dose1 463 fa.42 mo.42 x n 0.1 dose1 464 fa.42 mo.42 x n 0.1 dose1 465 fa.42 mo.42 x n 0.1 dose1 466 fa.46 mo.46 x y 0.1 dose1 467 fa.46 mo.46 x n 0.1 dose1 468 fa.46 mo.46 x n 0.1 dose1 469 fa.46 mo.46 x n 0.1 dose1 470 fa.46 mo.46 x n 0.1 dose1 471 fa.46 mo.46 x n 0.1 dose1 472 fa.46 mo.46 x n 0.1 dose1 473 fa.46 mo.46 x n 0.1 dose1 474 fa.46 mo.46 x n 0.1 dose1 475 fa.46 mo.46 x n 0.1 dose1 476 fa.46 mo.46 x n 0.1 dose1 477 fa.50 mo.50 x y 0.1 dose1 478 fa.50 mo.50 x n 0.1 dose1 479 fa.50 mo.50 x n 0.1 dose1 480 fa.50 mo.50 x n 0.1 dose1 481 fa.50 mo.50 x n 0.1 dose1 482 fa.50 mo.50 x n 0.1 dose1 483 fa.50 mo.50 x n 0.1 dose1 484 fa.50 mo.50 x n 0.1 dose1 485 fa.50 mo.50 x n 0.1 dose1 486 fa.50 mo.50 x n 0.1 dose1 487 fa.50 mo.50 x n 0.1 dose1 488 fa.54 mo.54 x n 0.1 dose1 489 fa.54 mo.54 x n 0.1 dose1 490 fa.54 mo.54 x n 0.1 dose1 491 fa.54 mo.54 x n 0.1 dose1 492 fa.54 mo.54 x n 0.1 dose1 493 fa.54 mo.54 x n 0.1 dose1 494 fa.54 mo.54 x n 0.1 dose1 495 fa.54 mo.54 x n 0.1 dose1 496 fa.54 mo.54 x n 0.1 dose1 497 fa.54 mo.54 x n 0.1 dose1 498 fa.54 mo.54 x n 0.1 dose1 499 fa.58 mo.58 x n 0.1 dose1 500 fa.58 mo.58 x n 0.1 dose1 501 fa.58 mo.58 x n 0.1 dose1 502 fa.58 mo.58 x n 0.1 dose1 503 fa.58 mo.58 x n 0.1 dose1 504 fa.58 mo.58 x n 0.1 dose1 505 fa.58 mo.58 x n 0.1 dose1 506 fa.58 mo.58 x n 0.1 dose1 507 fa.58 mo.58 x n 0.1 dose1 508 fa.58 mo.58 x n 0.1 dose1 509 fa.58 mo.58 x n 0.1 dose1 510 fa.58 mo.58 x n 0.1 dose1 511 fa.58 mo.58 x n 0.1 dose1 512 fa.62 mo.62 x n 0.1 dose1 513 fa.62 mo.62 x n 0.1 dose1 514 fa.62 mo.62 x n 0.1 dose1 515 fa.62 mo.62 x n 0.1 dose1 516 fa.62 mo.62 x n 0.1 dose1 517 fa.62 mo.62 x n 0.1 dose1 518 fa.62 mo.62 x n 0.1 dose1 519 fa.62 mo.62 x n 0.1 dose1 520 fa.62 mo.62 x n 0.1 dose1 521 fa.62 mo.62 x n 0.1 dose1 522 fa.66 mo.66 x y 0.1 dose1 523 fa.66 mo.66 x n 0.1 dose1 524 fa.66 mo.66 x n 0.1 dose1 525 fa.66 mo.66 x n 0.1 dose1 526 fa.66 mo.66 x n 0.1 dose1 527 fa.66 mo.66 x n 0.1 dose1 528 fa.66 mo.66 x n 0.1 dose1 529 fa.66 mo.66 x n 0.1 dose1 530 fa.66 mo.66 x n 0.1 dose1 531 fa.66 mo.66 x n 0.1 dose1 532 fa.66 mo.66 x n 0.1 dose1 533 fa.66 mo.66 x n 0.1 dose1 534 fa.70 mo.70 x n 0.1 dose1 535 fa.70 mo.70 x n 0.1 dose1 536 fa.70 mo.70 x n 0.1 dose1 537 fa.70 mo.70 x n 0.1 dose1 538 fa.70 mo.70 x n 0.1 dose1 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fa.7 mo.7 x n 0.2 dose2 672 fa.7 mo.7 x n 0.2 dose2 673 fa.7 mo.7 x n 0.2 dose2 674 fa.7 mo.7 x n 0.2 dose2 675 fa.7 mo.7 x n 0.2 dose2 676 fa.7 mo.7 x n 0.2 dose2 677 fa.7 mo.7 x n 0.2 dose2 678 fa.7 mo.7 x n 0.2 dose2 679 fa.7 mo.7 x n 0.2 dose2 680 fa.7 mo.7 x n 0.2 dose2 681 fa.7 mo.7 x n 0.2 dose2 682 fa.11 mo.11 x n 0.2 dose2 683 fa.11 mo.11 x n 0.2 dose2 684 fa.11 mo.11 x n 0.2 dose2 685 fa.11 mo.11 x n 0.2 dose2 686 fa.11 mo.11 x n 0.2 dose2 687 fa.11 mo.11 x n 0.2 dose2 688 fa.11 mo.11 x n 0.2 dose2 689 fa.11 mo.11 x n 0.2 dose2 690 fa.11 mo.11 x n 0.2 dose2 691 fa.11 mo.11 x n 0.2 dose2 692 fa.11 mo.11 x n 0.2 dose2 693 fa.15 mo.15 x n 0.2 dose2 694 fa.15 mo.15 x n 0.2 dose2 695 fa.15 mo.15 x n 0.2 dose2 696 fa.15 mo.15 x n 0.2 dose2 697 fa.15 mo.15 x n 0.2 dose2 698 fa.15 mo.15 x n 0.2 dose2 699 fa.15 mo.15 x n 0.2 dose2 700 fa.15 mo.15 x n 0.2 dose2 701 fa.15 mo.15 x n 0.2 dose2 702 fa.15 mo.15 x n 0.2 dose2 703 fa.15 mo.15 x n 0.2 dose2 704 fa.15 mo.15 x n 0.2 dose2 705 fa.15 mo.15 x n 0.2 dose2 706 fa.19 mo.19 x n 0.2 dose2 707 fa.19 mo.19 x n 0.2 dose2 708 fa.19 mo.19 x n 0.2 dose2 709 fa.19 mo.19 x n 0.2 dose2 710 fa.19 mo.19 x n 0.2 dose2 711 fa.19 mo.19 x n 0.2 dose2 712 fa.19 mo.19 x n 0.2 dose2 713 fa.19 mo.19 x n 0.2 dose2 714 fa.19 mo.19 x n 0.2 dose2 715 fa.19 mo.19 x n 0.2 dose2 716 fa.19 mo.19 x n 0.2 dose2 717 fa.19 mo.19 x n 0.2 dose2 718 fa.23 mo.23 x n 0.2 dose2 719 fa.23 mo.23 x n 0.2 dose2 720 fa.23 mo.23 x n 0.2 dose2 721 fa.23 mo.23 x n 0.2 dose2 722 fa.23 mo.23 x n 0.2 dose2 723 fa.23 mo.23 x n 0.2 dose2 724 fa.23 mo.23 x n 0.2 dose2 725 fa.23 mo.23 x n 0.2 dose2 726 fa.23 mo.23 x n 0.2 dose2 727 fa.23 mo.23 x n 0.2 dose2 728 fa.23 mo.23 x n 0.2 dose2 729 fa.23 mo.23 x n 0.2 dose2 730 fa.23 mo.23 x n 0.2 dose2 731 fa.23 mo.23 x n 0.2 dose2 732 fa.27 mo.27 x y 0.2 dose2 733 fa.27 mo.27 x y 0.2 dose2 734 fa.27 mo.27 x y 0.2 dose2 735 fa.27 mo.27 x y 0.2 dose2 736 fa.27 mo.27 x n 0.2 dose2 737 fa.27 mo.27 x n 0.2 dose2 738 fa.27 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0.2 dose2 772 fa.35 mo.35 x n 0.2 dose2 773 fa.39 mo.39 x y 0.2 dose2 774 fa.39 mo.39 x n 0.2 dose2 775 fa.39 mo.39 x n 0.2 dose2 776 fa.39 mo.39 x n 0.2 dose2 777 fa.39 mo.39 x n 0.2 dose2 778 fa.39 mo.39 x n 0.2 dose2 779 fa.43 mo.43 x y 0.2 dose2 780 fa.43 mo.43 x y 0.2 dose2 781 fa.43 mo.43 x n 0.2 dose2 782 fa.43 mo.43 x n 0.2 dose2 783 fa.43 mo.43 x n 0.2 dose2 784 fa.43 mo.43 x n 0.2 dose2 785 fa.43 mo.43 x n 0.2 dose2 786 fa.43 mo.43 x n 0.2 dose2 787 fa.43 mo.43 x n 0.2 dose2 788 fa.43 mo.43 x n 0.2 dose2 789 fa.43 mo.43 x n 0.2 dose2 790 fa.43 mo.43 x n 0.2 dose2 791 fa.43 mo.43 x n 0.2 dose2 792 fa.47 mo.47 x n 0.2 dose2 793 fa.47 mo.47 x n 0.2 dose2 794 fa.47 mo.47 x n 0.2 dose2 795 fa.47 mo.47 x n 0.2 dose2 796 fa.47 mo.47 x n 0.2 dose2 797 fa.47 mo.47 x n 0.2 dose2 798 fa.47 mo.47 x n 0.2 dose2 799 fa.47 mo.47 x n 0.2 dose2 800 fa.47 mo.47 x n 0.2 dose2 801 fa.47 mo.47 x n 0.2 dose2 802 fa.51 mo.51 x y 0.2 dose2 803 fa.51 mo.51 x n 0.2 dose2 804 fa.51 mo.51 x n 0.2 dose2 805 fa.51 mo.51 x n 0.2 dose2 806 fa.51 mo.51 x n 0.2 dose2 807 fa.51 mo.51 x n 0.2 dose2 808 fa.51 mo.51 x n 0.2 dose2 809 fa.51 mo.51 x n 0.2 dose2 810 fa.51 mo.51 x n 0.2 dose2 811 fa.51 mo.51 x n 0.2 dose2 812 fa.51 mo.51 x n 0.2 dose2 813 fa.51 mo.51 x n 0.2 dose2 814 fa.51 mo.51 x n 0.2 dose2 815 fa.51 mo.51 x n 0.2 dose2 816 fa.55 mo.55 x y 0.2 dose2 817 fa.55 mo.55 x n 0.2 dose2 818 fa.55 mo.55 x n 0.2 dose2 819 fa.55 mo.55 x n 0.2 dose2 820 fa.55 mo.55 x n 0.2 dose2 821 fa.55 mo.55 x n 0.2 dose2 822 fa.55 mo.55 x n 0.2 dose2 823 fa.55 mo.55 x n 0.2 dose2 824 fa.55 mo.55 x n 0.2 dose2 825 fa.55 mo.55 x n 0.2 dose2 826 fa.55 mo.55 x n 0.2 dose2 827 fa.55 mo.55 x n 0.2 dose2 828 fa.59 mo.59 x n 0.2 dose2 829 fa.59 mo.59 x n 0.2 dose2 830 fa.59 mo.59 x n 0.2 dose2 831 fa.59 mo.59 x n 0.2 dose2 832 fa.59 mo.59 x n 0.2 dose2 833 fa.59 mo.59 x n 0.2 dose2 834 fa.59 mo.59 x n 0.2 dose2 835 fa.59 mo.59 x n 0.2 dose2 836 fa.59 mo.59 x n 0.2 dose2 837 fa.59 mo.59 x n 0.2 dose2 838 fa.63 mo.63 x n 0.2 dose2 839 fa.63 mo.63 x n 0.2 dose2 840 fa.63 mo.63 x n 0.2 dose2 841 fa.63 mo.63 x n 0.2 dose2 842 fa.63 mo.63 x n 0.2 dose2 843 fa.63 mo.63 x n 0.2 dose2 844 fa.63 mo.63 x n 0.2 dose2 845 fa.63 mo.63 x n 0.2 dose2 846 fa.63 mo.63 x n 0.2 dose2 847 fa.67 mo.67 x y 0.2 dose2 848 fa.67 mo.67 x n 0.2 dose2 849 fa.67 mo.67 x n 0.2 dose2 850 fa.67 mo.67 x n 0.2 dose2 851 fa.67 mo.67 x n 0.2 dose2 852 fa.67 mo.67 x n 0.2 dose2 853 fa.67 mo.67 x n 0.2 dose2 854 fa.67 mo.67 x n 0.2 dose2 855 fa.67 mo.67 x n 0.2 dose2 856 fa.67 mo.67 x n 0.2 dose2 857 fa.67 mo.67 x n 0.2 dose2 858 fa.67 mo.67 x n 0.2 dose2 859 fa.71 mo.71 x n 0.2 dose2 860 fa.71 mo.71 x n 0.2 dose2 861 fa.71 mo.71 x n 0.2 dose2 862 fa.71 mo.71 x n 0.2 dose2 863 fa.71 mo.71 x n 0.2 dose2 864 fa.71 mo.71 x n 0.2 dose2 865 fa.71 mo.71 x n 0.2 dose2 866 fa.71 mo.71 x n 0.2 dose2 867 fa.71 mo.71 x n 0.2 dose2 868 fa.71 mo.71 x n 0.2 dose2 869 fa.71 mo.71 x n 0.2 dose2 870 fa.71 mo.71 x n 0.2 dose2 871 fa.71 mo.71 x n 0.2 dose2 872 fa.75 mo.75 x y 0.2 dose2 873 fa.75 mo.75 x n 0.2 dose2 874 fa.75 mo.75 x n 0.2 dose2 875 fa.75 mo.75 x n 0.2 dose2 876 fa.75 mo.75 x n 0.2 dose2 877 fa.75 mo.75 x n 0.2 dose2 878 fa.75 mo.75 x n 0.2 dose2 879 fa.75 mo.75 x n 0.2 dose2 880 fa.75 mo.75 x n 0.2 dose2 881 fa.75 mo.75 x n 0.2 dose2 882 fa.75 mo.75 x n 0.2 dose2 883 fa.75 mo.75 x n 0.2 dose2 884 fa.75 mo.75 x n 0.2 dose2 885 fa.75 mo.75 x n 0.2 dose2 886 fa.79 mo.79 x n 0.2 dose2 887 fa.79 mo.79 x n 0.2 dose2 888 fa.79 mo.79 x n 0.2 dose2 889 fa.79 mo.79 x n 0.2 dose2 890 fa.79 mo.79 x n 0.2 dose2 891 fa.79 mo.79 x n 0.2 dose2 892 fa.79 mo.79 x n 0.2 dose2 893 fa.79 mo.79 x n 0.2 dose2 894 fa.79 mo.79 x n 0.2 dose2 895 fa.79 mo.79 x n 0.2 dose2 896 fa.79 mo.79 x n 0.2 dose2 897 fa.79 mo.79 x n 0.2 dose2 898 fa.79 mo.79 x n 0.2 dose2 899 fa.83 mo.83 x n 0.2 dose2 900 fa.83 mo.83 x n 0.2 dose2 901 fa.83 mo.83 x n 0.2 dose2 902 fa.83 mo.83 x n 0.2 dose2 903 fa.83 mo.83 x n 0.2 dose2 904 fa.83 mo.83 x n 0.2 dose2 905 fa.83 mo.83 x n 0.2 dose2 906 fa.83 mo.83 x n 0.2 dose2 907 fa.83 mo.83 x n 0.2 dose2 908 fa.83 mo.83 x n 0.2 dose2 909 fa.83 mo.83 x n 0.2 dose2 910 fa.83 mo.83 x n 0.2 dose2 911 fa.83 mo.83 x n 0.2 dose2 912 fa.83 mo.83 x n 0.2 dose2 913 fa.87 mo.87 x y 0.2 dose2 914 fa.87 mo.87 x n 0.2 dose2 915 fa.87 mo.87 x n 0.2 dose2 916 fa.87 mo.87 x n 0.2 dose2 917 fa.87 mo.87 x n 0.2 dose2 918 fa.87 mo.87 x n 0.2 dose2 919 fa.87 mo.87 x n 0.2 dose2 920 fa.87 mo.87 x n 0.2 dose2 921 fa.87 mo.87 x n 0.2 dose2 922 fa.87 mo.87 x n 0.2 dose2 923 fa.87 mo.87 x n 0.2 dose2 924 fa.87 mo.87 x n 0.2 dose2 925 fa.87 mo.87 x n 0.2 dose2 926 fa.91 mo.91 x y 0.2 dose2 927 fa.91 mo.91 x y 0.2 dose2 928 fa.91 mo.91 x n 0.2 dose2 929 fa.91 mo.91 x n 0.2 dose2 930 fa.91 mo.91 x n 0.2 dose2 931 fa.91 mo.91 x n 0.2 dose2 932 fa.91 mo.91 x n 0.2 dose2 933 fa.91 mo.91 x n 0.2 dose2 934 fa.91 mo.91 x n 0.2 dose2 935 fa.91 mo.91 x n 0.2 dose2 936 fa.91 mo.91 x n 0.2 dose2 937 fa.91 mo.91 x n 0.2 dose2 938 fa.95 mo.95 x y 0.2 dose2 939 fa.95 mo.95 x n 0.2 dose2 940 fa.95 mo.95 x n 0.2 dose2 941 fa.95 mo.95 x n 0.2 dose2 942 fa.95 mo.95 x n 0.2 dose2 943 fa.95 mo.95 x n 0.2 dose2 944 fa.95 mo.95 x n 0.2 dose2 945 fa.95 mo.95 x n 0.2 dose2 946 fa.95 mo.95 x n 0.2 dose2 947 fa.95 mo.95 x n 0.2 dose2 948 fa.95 mo.95 x n 0.2 dose2 949 fa.95 mo.95 x n 0.2 dose2 950 fa.95 mo.95 x n 0.2 dose2 951 fa.95 mo.95 x n 0.2 dose2 952 fa.99 mo.99 x n 0.2 dose2 953 fa.99 mo.99 x n 0.2 dose2 954 fa.99 mo.99 x n 0.2 dose2 955 fa.99 mo.99 x n 0.2 dose2 956 fa.99 mo.99 x n 0.2 dose2 957 fa.99 mo.99 x n 0.2 dose2 958 fa.99 mo.99 x n 0.2 dose2 959 fa.99 mo.99 x n 0.2 dose2 960 fa.99 mo.99 x n 0.2 dose2 961 fa.99 mo.99 x n 0.2 dose2 962 fa.99 mo.99 x n 0.2 dose2 963 fa.99 mo.99 x n 0.2 dose2 964 fa.99 mo.99 x n 0.2 dose2 965 fa.103 mo.103 x n 0.2 dose2 966 fa.103 mo.103 x n 0.2 dose2 967 fa.103 mo.103 x n 0.2 dose2 968 fa.103 mo.103 x n 0.2 dose2 969 fa.103 mo.103 x n 0.2 dose2 970 fa.103 mo.103 x n 0.2 dose2 971 fa.103 mo.103 x n 0.2 dose2 972 fa.103 mo.103 x n 0.2 dose2 973 fa.103 mo.103 x n 0.2 dose2 974 fa.103 mo.103 x n 0.2 dose2 975 fa.103 mo.103 x n 0.2 dose2 976 fa.103 mo.103 x n 0.2 dose2 977 fa.107 mo.107 x y 0.2 dose2 978 fa.107 mo.107 x n 0.2 dose2 979 fa.107 mo.107 x n 0.2 dose2 980 fa.107 mo.107 x n 0.2 dose2 981 fa.107 mo.107 x n 0.2 dose2 982 fa.107 mo.107 x n 0.2 dose2 983 fa.107 mo.107 x n 0.2 dose3 984 fa.4 mo.4 x y 0.4 dose3 985 fa.4 mo.4 x y 0.4 dose3 986 fa.4 mo.4 x y 0.4 dose3 987 fa.4 mo.4 x y 0.4 dose3 988 fa.4 mo.4 x y 0.4 dose3 989 fa.4 mo.4 x y 0.4 dose3 990 fa.4 mo.4 x y 0.4 dose3 991 fa.4 mo.4 x y 0.4 dose3 992 fa.4 mo.4 x y 0.4 dose3 993 fa.4 mo.4 x y 0.4 dose3 994 fa.4 mo.4 x y 0.4 dose3 995 fa.4 mo.4 x y 0.4 dose3 996 fa.8 mo.8 x y 0.4 dose3 997 fa.8 mo.8 x n 0.4 dose3 998 fa.8 mo.8 x n 0.4 dose3 999 fa.8 mo.8 x n 0.4 dose3 1000 fa.8 mo.8 x n 0.4 dose3 1001 fa.8 mo.8 x n 0.4 dose3 1002 fa.8 mo.8 x n 0.4 dose3 1003 fa.8 mo.8 x n 0.4 dose3 1004 fa.8 mo.8 x n 0.4 dose3 1005 fa.8 mo.8 x n 0.4 dose3 1006 fa.8 mo.8 x n 0.4 dose3 1007 fa.8 mo.8 x n 0.4 dose3 1008 fa.12 mo.12 x n 0.4 dose3 1009 fa.12 mo.12 x n 0.4 dose3 1010 fa.12 mo.12 x n 0.4 dose3 1011 fa.12 mo.12 x n 0.4 dose3 1012 fa.12 mo.12 x n 0.4 dose3 1013 fa.12 mo.12 x n 0.4 dose3 1014 fa.12 mo.12 x n 0.4 dose3 1015 fa.12 mo.12 x n 0.4 dose3 1016 fa.12 mo.12 x n 0.4 dose3 1017 fa.12 mo.12 x n 0.4 dose3 1018 fa.12 mo.12 x n 0.4 dose3 1019 fa.12 mo.12 x n 0.4 dose3 1020 fa.12 mo.12 x n 0.4 dose3 1021 fa.16 mo.16 x y 0.4 dose3 1022 fa.16 mo.16 x y 0.4 dose3 1023 fa.16 mo.16 x n 0.4 dose3 1024 fa.16 mo.16 x n 0.4 dose3 1025 fa.16 mo.16 x n 0.4 dose3 1026 fa.16 mo.16 x n 0.4 dose3 1027 fa.16 mo.16 x n 0.4 dose3 1028 fa.16 mo.16 x n 0.4 dose3 1029 fa.20 mo.20 x y 0.4 dose3 1030 fa.20 mo.20 x y 0.4 dose3 1031 fa.20 mo.20 x n 0.4 dose3 1032 fa.20 mo.20 x n 0.4 dose3 1033 fa.20 mo.20 x n 0.4 dose3 1034 fa.20 mo.20 x n 0.4 dose3 1035 fa.20 mo.20 x n 0.4 dose3 1036 fa.20 mo.20 x n 0.4 dose3 1037 fa.20 mo.20 x n 0.4 dose3 1038 fa.20 mo.20 x n 0.4 dose3 1039 fa.20 mo.20 x n 0.4 dose3 1040 fa.20 mo.20 x n 0.4 dose3 1041 fa.24 mo.24 x y 0.4 dose3 1042 fa.24 mo.24 x y 0.4 dose3 1043 fa.24 mo.24 x y 0.4 dose3 1044 fa.24 mo.24 x y 0.4 dose3 1045 fa.24 mo.24 x n 0.4 dose3 1046 fa.24 mo.24 x n 0.4 dose3 1047 fa.24 mo.24 x n 0.4 dose3 1048 fa.24 mo.24 x n 0.4 dose3 1049 fa.24 mo.24 x n 0.4 dose3 1050 fa.24 mo.24 x n 0.4 dose3 1051 fa.24 mo.24 x n 0.4 dose3 1052 fa.24 mo.24 x n 0.4 dose3 1053 fa.24 mo.24 x n 0.4 dose3 1054 fa.28 mo.28 x n 0.4 dose3 1055 fa.28 mo.28 x n 0.4 dose3 1056 fa.28 mo.28 x n 0.4 dose3 1057 fa.28 mo.28 x n 0.4 dose3 1058 fa.28 mo.28 x n 0.4 dose3 1059 fa.28 mo.28 x n 0.4 dose3 1060 fa.28 mo.28 x n 0.4 dose3 1061 fa.28 mo.28 x n 0.4 dose3 1062 fa.28 mo.28 x n 0.4 dose3 1063 fa.28 mo.28 x n 0.4 dose3 1064 fa.28 mo.28 x n 0.4 dose3 1065 fa.28 mo.28 x n 0.4 dose3 1066 fa.28 mo.28 x n 0.4 dose3 1067 fa.32 mo.32 x y 0.4 dose3 1068 fa.32 mo.32 x n 0.4 dose3 1069 fa.32 mo.32 x n 0.4 dose3 1070 fa.32 mo.32 x n 0.4 dose3 1071 fa.32 mo.32 x n 0.4 dose3 1072 fa.32 mo.32 x n 0.4 dose3 1073 fa.32 mo.32 x n 0.4 dose3 1074 fa.32 mo.32 x n 0.4 dose3 1075 fa.32 mo.32 x n 0.4 dose3 1076 fa.32 mo.32 x n 0.4 dose3 1077 fa.32 mo.32 x n 0.4 dose3 1078 fa.32 mo.32 x n 0.4 dose3 1079 fa.32 mo.32 x n 0.4 dose3 1080 fa.36 mo.36 x n 0.4 dose3 1081 fa.36 mo.36 x n 0.4 dose3 1082 fa.36 mo.36 x n 0.4 dose3 1083 fa.36 mo.36 x n 0.4 dose3 1084 fa.36 mo.36 x n 0.4 dose3 1085 fa.36 mo.36 x n 0.4 dose3 1086 fa.36 mo.36 x n 0.4 dose3 1087 fa.36 mo.36 x n 0.4 dose3 1088 fa.36 mo.36 x n 0.4 dose3 1089 fa.36 mo.36 x n 0.4 dose3 1090 fa.36 mo.36 x n 0.4 dose3 1091 fa.36 mo.36 x n 0.4 dose3 1092 fa.40 mo.40 x y 0.4 dose3 1093 fa.40 mo.40 x n 0.4 dose3 1094 fa.40 mo.40 x n 0.4 dose3 1095 fa.40 mo.40 x n 0.4 dose3 1096 fa.40 mo.40 x n 0.4 dose3 1097 fa.40 mo.40 x n 0.4 dose3 1098 fa.40 mo.40 x n 0.4 dose3 1099 fa.40 mo.40 x n 0.4 dose3 1100 fa.40 mo.40 x n 0.4 dose3 1101 fa.44 mo.44 x y 0.4 dose3 1102 fa.44 mo.44 x y 0.4 dose3 1103 fa.44 mo.44 x y 0.4 dose3 1104 fa.44 mo.44 x n 0.4 dose3 1105 fa.44 mo.44 x n 0.4 dose3 1106 fa.44 mo.44 x n 0.4 dose3 1107 fa.44 mo.44 x n 0.4 dose3 1108 fa.44 mo.44 x n 0.4 dose3 1109 fa.44 mo.44 x n 0.4 dose3 1110 fa.48 mo.48 x n 0.4 dose3 1111 fa.48 mo.48 x n 0.4 dose3 1112 fa.48 mo.48 x n 0.4 dose3 1113 fa.48 mo.48 x n 0.4 dose3 1114 fa.48 mo.48 x n 0.4 dose3 1115 fa.48 mo.48 x n 0.4 dose3 1116 fa.48 mo.48 x n 0.4 dose3 1117 fa.48 mo.48 x n 0.4 dose3 1118 fa.48 mo.48 x n 0.4 dose3 1119 fa.48 mo.48 x n 0.4 dose3 1120 fa.48 mo.48 x n 0.4 dose3 1121 fa.52 mo.52 x y 0.4 dose3 1122 fa.52 mo.52 x n 0.4 dose3 1123 fa.52 mo.52 x n 0.4 dose3 1124 fa.52 mo.52 x n 0.4 dose3 1125 fa.52 mo.52 x n 0.4 dose3 1126 fa.52 mo.52 x n 0.4 dose3 1127 fa.52 mo.52 x n 0.4 dose3 1128 fa.52 mo.52 x n 0.4 dose3 1129 fa.52 mo.52 x n 0.4 dose3 1130 fa.52 mo.52 x n 0.4 dose3 1131 fa.52 mo.52 x n 0.4 dose3 1132 fa.52 mo.52 x n 0.4 dose3 1133 fa.52 mo.52 x n 0.4 dose3 1134 fa.52 mo.52 x n 0.4 dose3 1135 fa.56 mo.56 x n 0.4 dose3 1136 fa.56 mo.56 x n 0.4 dose3 1137 fa.56 mo.56 x n 0.4 dose3 1138 fa.56 mo.56 x n 0.4 dose3 1139 fa.56 mo.56 x n 0.4 dose3 1140 fa.56 mo.56 x n 0.4 dose3 1141 fa.56 mo.56 x n 0.4 dose3 1142 fa.56 mo.56 x n 0.4 dose3 1143 fa.56 mo.56 x n 0.4 dose3 1144 fa.56 mo.56 x n 0.4 dose3 1145 fa.60 mo.60 x y 0.4 dose3 1146 fa.60 mo.60 x y 0.4 dose3 1147 fa.60 mo.60 x y 0.4 dose3 1148 fa.60 mo.60 x n 0.4 dose3 1149 fa.60 mo.60 x n 0.4 dose3 1150 fa.60 mo.60 x n 0.4 dose3 1151 fa.60 mo.60 x n 0.4 dose3 1152 fa.60 mo.60 x n 0.4 dose3 1153 fa.60 mo.60 x n 0.4 dose3 1154 fa.60 mo.60 x n 0.4 dose3 1155 fa.60 mo.60 x n 0.4 dose3 1156 fa.60 mo.60 x n 0.4 dose3 1157 fa.64 mo.64 x y 0.4 dose3 1158 fa.64 mo.64 x y 0.4 dose3 1159 fa.64 mo.64 x n 0.4 dose3 1160 fa.64 mo.64 x n 0.4 dose3 1161 fa.64 mo.64 x n 0.4 dose3 1162 fa.64 mo.64 x n 0.4 dose3 1163 fa.64 mo.64 x n 0.4 dose3 1164 fa.64 mo.64 x n 0.4 dose3 1165 fa.64 mo.64 x n 0.4 dose3 1166 fa.64 mo.64 x n 0.4 dose3 1167 fa.64 mo.64 x n 0.4 dose3 1168 fa.64 mo.64 x n 0.4 dose3 1169 fa.64 mo.64 x n 0.4 dose3 1170 fa.64 mo.64 x n 0.4 dose3 1171 fa.64 mo.64 x n 0.4 dose3 1172 fa.64 mo.64 x n 0.4 dose3 1173 fa.64 mo.64 x n 0.4 dose3 1174 fa.64 mo.64 x n 0.4 dose3 1175 fa.64 mo.64 x n 0.4 dose3 1176 fa.64 mo.64 x n 0.4 dose3 1177 fa.64 mo.64 x n 0.4 dose3 1178 fa.68 mo.68 x y 0.4 dose3 1179 fa.68 mo.68 x y 0.4 dose3 1180 fa.68 mo.68 x y 0.4 dose3 1181 fa.68 mo.68 x n 0.4 dose3 1182 fa.68 mo.68 x n 0.4 dose3 1183 fa.68 mo.68 x n 0.4 dose3 1184 fa.68 mo.68 x n 0.4 dose3 1185 fa.68 mo.68 x n 0.4 dose3 1186 fa.68 mo.68 x n 0.4 dose3 1187 fa.68 mo.68 x n 0.4 dose3 1188 fa.72 mo.72 x y 0.4 dose3 1189 fa.72 mo.72 x y 0.4 dose3 1190 fa.72 mo.72 x y 0.4 dose3 1191 fa.72 mo.72 x n 0.4 dose3 1192 fa.72 mo.72 x n 0.4 dose3 1193 fa.72 mo.72 x n 0.4 dose3 1194 fa.72 mo.72 x n 0.4 dose3 1195 fa.72 mo.72 x n 0.4 dose3 1196 fa.72 mo.72 x n 0.4 dose3 1197 fa.72 mo.72 x n 0.4 dose3 1198 fa.72 mo.72 x n 0.4 dose3 1199 fa.76 mo.76 x y 0.4 dose3 1200 fa.76 mo.76 x n 0.4 dose3 1201 fa.76 mo.76 x n 0.4 dose3 1202 fa.76 mo.76 x n 0.4 dose3 1203 fa.76 mo.76 x n 0.4 dose3 1204 fa.76 mo.76 x n 0.4 dose3 1205 fa.76 mo.76 x n 0.4 dose3 1206 fa.76 mo.76 x n 0.4 dose3 1207 fa.76 mo.76 x n 0.4 dose3 1208 fa.76 mo.76 x n 0.4 dose3 1209 fa.76 mo.76 x n 0.4 dose3 1210 fa.80 mo.80 x y 0.4 dose3 1211 fa.80 mo.80 x n 0.4 dose3 1212 fa.80 mo.80 x n 0.4 dose3 1213 fa.80 mo.80 x n 0.4 dose3 1214 fa.80 mo.80 x n 0.4 dose3 1215 fa.80 mo.80 x n 0.4 dose3 1216 fa.80 mo.80 x n 0.4 dose3 1217 fa.80 mo.80 x n 0.4 dose3 1218 fa.80 mo.80 x n 0.4 dose3 1219 fa.80 mo.80 x n 0.4 dose3 1220 fa.80 mo.80 x n 0.4 dose3 1221 fa.84 mo.84 x n 0.4 dose3 1222 fa.84 mo.84 x n 0.4 dose3 1223 fa.84 mo.84 x n 0.4 dose3 1224 fa.84 mo.84 x n 0.4 dose3 1225 fa.84 mo.84 x n 0.4 dose3 1226 fa.84 mo.84 x n 0.4 dose3 1227 fa.84 mo.84 x y 0.4 dose3 1228 fa.84 mo.84 x y 0.4 dose3 1229 fa.84 mo.84 x y 0.4 dose3 1230 fa.84 mo.84 x y 0.4 dose3 1231 fa.84 mo.84 x y 0.4 dose3 1232 fa.84 mo.84 x y 0.4 dose3 1233 fa.84 mo.84 x y 0.4 dose3 1234 fa.84 mo.84 x y 0.4 dose3 1235 fa.88 mo.88 x n 0.4 dose3 1236 fa.88 mo.88 x n 0.4 dose3 1237 fa.88 mo.88 x n 0.4 dose3 1238 fa.88 mo.88 x n 0.4 dose3 1239 fa.88 mo.88 x n 0.4 dose3 1240 fa.88 mo.88 x n 0.4 dose3 1241 fa.88 mo.88 x n 0.4 dose3 1242 fa.88 mo.88 x n 0.4 dose3 1243 fa.88 mo.88 x n 0.4 dose3 1244 fa.88 mo.88 x n 0.4 dose3 1245 fa.88 mo.88 x n 0.4 dose3 1246 fa.88 mo.88 x n 0.4 dose3 1247 fa.88 mo.88 x n 0.4 dose3 1248 fa.88 mo.88 x n 0.4 dose3 1249 fa.88 mo.88 x n 0.4 dose3 1250 fa.92 mo.92 x y 0.4 dose3 1251 fa.92 mo.92 x y 0.4 dose3 1252 fa.92 mo.92 x n 0.4 dose3 1253 fa.92 mo.92 x n 0.4 dose3 1254 fa.92 mo.92 x n 0.4 dose3 1255 fa.92 mo.92 x n 0.4 dose3 1256 fa.92 mo.92 x n 0.4 dose3 1257 fa.92 mo.92 x n 0.4 dose3 1258 fa.92 mo.92 x n 0.4 dose3 1259 fa.92 mo.92 x n 0.4 dose3 1260 fa.92 mo.92 x n 0.4 dose3 1261 fa.92 mo.92 x n 0.4 dose3 1262 fa.92 mo.92 x n 0.4 dose3 1263 fa.96 mo.96 x y 0.4 dose3 1264 fa.96 mo.96 x y 0.4 dose3 1265 fa.96 mo.96 x y 0.4 dose3 1266 fa.96 mo.96 x y 0.4 dose3 1267 fa.96 mo.96 x y 0.4 dose3 1268 fa.96 mo.96 x y 0.4 dose3 1269 fa.96 mo.96 x y 0.4 dose3 1270 fa.96 mo.96 x y 0.4 dose3 1271 fa.96 mo.96 x n 0.4 dose3 1272 fa.96 mo.96 x n 0.4 dose3 1273 fa.96 mo.96 x n 0.4 dose3 1274 fa.100 mo.100 x y 0.4 dose3 1275 fa.100 mo.100 x y 0.4 dose3 1276 fa.100 mo.100 x y 0.4 dose3 1277 fa.100 mo.100 x y 0.4 dose3 1278 fa.100 mo.100 x n 0.4 dose3 1279 fa.100 mo.100 x n 0.4 dose3 1280 fa.100 mo.100 x n 0.4 dose3 1281 fa.100 mo.100 x n 0.4 dose3 1282 fa.100 mo.100 x n 0.4 dose3 1283 fa.100 mo.100 x n 0.4 dose3 1284 fa.100 mo.100 x n 0.4 dose3 1285 fa.100 mo.100 x n 0.4 dose3 1286 fa.104 mo.104 x y 0.4 dose3 1287 fa.104 mo.104 x y 0.4 dose3 1288 fa.104 mo.104 x n 0.4 dose3 1289 fa.104 mo.104 x n 0.4 dose3 1290 fa.104 mo.104 x n 0.4 dose3 1291 fa.104 mo.104 x n 0.4 dose3 1292 fa.104 mo.104 x n 0.4 dose3 1293 fa.104 mo.104 x n 0.4 dose3 1294 fa.104 mo.104 x n 0.4 dose3 1295 fa.104 mo.104 x n 0.4 dose3 1296 fa.104 mo.104 x n 0.4 dose3 1297 fa.104 mo.104 x n 0.4 ;;;; run # # Test if dose affects intralitter correlation as well as mean # Slaton et al's LRTS gave X2(df=3)=15.66 # but this is using a beta-logistic model rather than the # gaussian-logistic # # -- uncomment the next lines to do the analysis # set iter 1000 # set chains 4 # fpm nonviable nqtl 0 c s cov dose # fpm nonviable nqtl 0 s cov dose # lrt # # Produce equivalent test of toxicity to that of Slaton et al: # X2(df=2)=21.71 # # fpm nonviable nqtl 0 c s cov dose # fpm nonviable nqtl 0 s # lrt