Sib-pair Command: ito

Class	Global Utility
Name	ito
Arguments	<Frequency of A allele> [<Penetrance of AA genotype> <Penetrance of AB genotype> <Penetrance of BB genotype>]

Calculates conditional genotype frequencies for a relative of a proband of given genotype (if only allele frequency provided) or affection status under the specified diallelic generalized single major locus model (if penetrances were also specified). ITO refers to the matrices used to perform the calculation for pairs of relatives.

Example:

>> ito 0.0001
               Sibling           Par-Off           2nd degree        3rd degree
Proband Freq   A/A   A/B   B/B   A/A   A/B   B/B   A/A   A/B   B/B   A/A   A/B   B/B
------- ----   ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
A/A     0.000  0.250 0.500 0.250 0.000 1.000 0.000 0.000 0.500 0.500 0.000 0.250 0.750
A/B     0.000  0.000 0.500 0.500 0.000 0.500 0.500 0.000 0.250 0.750 0.000 0.125 0.875
B/B     1.000  0.000 0.000 1.000 0.000 0.000 1.000 0.000 0.000 1.000 0.000 0.000 1.000
>> ito 0.0001 0.5 0.5 0.0
               Sibling           Par-Off           2nd degree        3rd degree
Proband Freq   A/A   A/B   B/B   A/A   A/B   B/B   A/A   A/B   B/B   A/A   A/B   B/B
------- ----   ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
Aff     0.000  0.000 0.500 0.500 0.000 0.500 0.500 0.000 0.250 0.750 0.000 0.125 0.875
UnA     1.000  0.000 0.000 1.000 0.000 0.000 1.000 0.000 0.000 1.000 0.000 0.000 1.000