|
|
| PMID |
|
|
| TITLE |
|
| ADH genotypes and alcohol use and dependence in Europeans. |
|
| ABSTRACT |
|
|
|
| We have tested for effects of alcohol dehydrogenase (ADH) genotypes on self-reported alcohol consumption and symptoms of alcohol dependence, recorded on three occasions up to 15 years apart, in 377 male and female subjects of European descent. ADH2 genotype had significant effects on both consumption and dependence in the men, but not in the women. The effects of ADH3 genotype were considerably less than those of ADH2, but significant results could be demonstrated when the combined genotypes were considered. The direction of the effects on alcohol consumption and dependence risk were consistent with reports on Asian subjects, and with the in vitro properties of ADH isoenzymes. As with previous studies on the relationship between ADH type and alcohol use, population stratification cannot be excluded as a contributing factor in these results. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1998/11/05 |
| medline |
1998/11/05 00:01 |
| entrez |
1998/11/05 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Whitfield JB |
|
Whitfield |
J B |
JB |
|
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia. |
| Nightingale BN |
|
Nightingale |
B N |
BN |
|
|
| Bucholz KK |
|
Bucholz |
K K |
KK |
|
|
| Madden PA |
|
Madden |
P A |
PA |
|
|
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 22 |
| ISSUE: 7 |
| TITLE: Alcoholism, clinical and experimental research |
| ISOABBREVIATION: Alcohol. Clin. Exp. Res. |
| YEAR: 1998 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0145-6008 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Alcohol Clin Exp Res |
| COUNTRY: England |
| ISSNLINKING: 0145-6008 |
| NLMUNIQUEID: 7707242 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Alcohol Dehydrogenase |
genetics |
| Alcoholism |
genetics |
| Australia |
genetics |
| Ethnic Groups |
genetics |
| Europe |
ethnology |
| European Continental Ancestry Group |
genetics |
| Female |
genetics |
| Genetics, Population |
genetics |
| Genotype |
genetics |
| Humans |
genetics |
| Isoenzymes |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Risk |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Isoenzymes |
| EC 1.1.1.1 |
Alcohol Dehydrogenase |
|
| OTHER ID's |
|
|
|
