|
|
| PMID |
|
|
| TITLE |
|
| Common genetic risk factors for conduct disorder and alcohol dependence. |
|
| ABSTRACT |
|
|
|
| The association between retrospectively reported childhood conduct disorder (CD) and a history of alcohol dependence (AD) was examined in a sample of 2,682 male, female, and unlike-sex adult twin pairs. There was a strong association between CD and AD in both men (tetrachoric r = .34, odds ratio = 2.8) and women (tetrachoric r = .53, odds ratio = 9.9). Genetic factors accounted for most of the association between CD and AD liability in men and women, with the remainder of the association being due to nonshared individual-specific environmental factors. Genetic influences common to CD and AD accounted for 17% and 35% of the genetic variation in AD liability in men and women, respectively, and accounted for 11% and 23% of the total variation in AD liability in men and women, respectively. The results suggest that there are common genetic risk factors for CD and AD or that CD itself is an important genetically influenced risk factor for AD. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1998/08/26 |
| medline |
1998/08/26 00:01 |
| entrez |
1998/08/26 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Slutske WS |
|
Slutske |
W S |
WS |
|
Department of Psychology, University of Missouri-Columbia 65211, USA. psycws@showme.missouri.edu |
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Dinwiddie SH |
|
Dinwiddie |
S H |
SH |
|
|
| Madden PA |
|
Madden |
P A |
PA |
|
|
| Bucholz KK |
|
Bucholz |
K K |
KK |
|
|
| Dunne MP |
|
Dunne |
M P |
MP |
|
|
| Statham DJ |
|
Statham |
D J |
DJ |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 107 |
| ISSUE: 3 |
| TITLE: Journal of abnormal psychology |
| ISOABBREVIATION: J Abnorm Psychol |
| YEAR: 1998 |
| MONTH: Aug |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0021-843X |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Abnorm Psychol |
| COUNTRY: United States |
| ISSNLINKING: 0021-843X |
| NLMUNIQUEID: 0034461 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Alcohol-Related Disorders |
genetics |
| Australia |
epidemiology |
| Chi-Square Distribution |
epidemiology |
| Comorbidity |
epidemiology |
| Conduct Disorder |
genetics |
| Female |
genetics |
| Humans |
genetics |
| Least-Squares Analysis |
genetics |
| Likelihood Functions |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Models, Genetic |
genetics |
| Odds Ratio |
genetics |
| Retrospective Studies |
genetics |
| Risk Factors |
genetics |
| Twins, Dizygotic |
statistics & numerical data |
| Twins, Monozygotic |
statistics & numerical data |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
