|
|
| PMID |
|
|
| TITLE |
|
| Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Genetic influences on alcoholism risk are well-documented in men, but uncertain in women. We tested for gender differences in genetic influences on, and risk-factors for, DSM-III-R alcohol dependence (AD). |
| METHOD |
NlmCategory: METHODS |
| Diagnostic follow-up interviews were conducted in 1992-3 by telephone with twins from an Australian twin panel first surveyed in 1980-82 (N = 5889 respondents). Data were analysed using logistic regression models. |
| RESULTS |
NlmCategory: RESULTS |
| Significantly higher twin pair concordances were observed in MZ compared to DZ same-sex twin pairs in women and men, even when data were weighted to adjust for over-representation of well-educated respondents, and for selective attrition. AD risk was increased in younger birth cohorts, in Catholic males or women reporting no religious affiliation, in those reporting a history of conduct disorder or major depression and in those with high Neuroticism, Social Non-conformity, Toughmindedness, Novelty-Seeking or (in women only) Extraversion scores; and decreased in 'Other Protestants', weekly church attenders, and university-educated males. Controlling for these variables, however, did not remove the significant association with having an alcoholic MZ co-twin, implying that much of the genetic influence on AD risk remained unexplained. No significant gender difference in the genetic variance in AD was found (64% heritability, 95% confidence interval 32-73%). |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Genetic risk-factors play as important a role in determining AD risk in women as in men. With the exception of certain sociocultural variables such as religious affiliation, the same personality, sociodemographic and axis I correlates of alcoholism risk are observed in women and men. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1997/12/24 |
| medline |
1997/12/24 00:01 |
| entrez |
1997/12/24 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Heath AC |
|
Heath |
A C |
AC |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA. |
| Bucholz KK |
|
Bucholz |
K K |
KK |
|
|
| Madden PA |
|
Madden |
P A |
PA |
|
|
| Dinwiddie SH |
|
Dinwiddie |
S H |
SH |
|
|
| Slutske WS |
|
Slutske |
W S |
WS |
|
|
| Bierut LJ |
|
Bierut |
L J |
LJ |
|
|
| Statham DJ |
|
Statham |
D J |
DJ |
|
|
| Dunne MP |
|
Dunne |
M P |
MP |
|
|
| Whitfield JB |
|
Whitfield |
J B |
JB |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 27 |
| ISSUE: 6 |
| TITLE: Psychological medicine |
| ISOABBREVIATION: Psychol Med |
| YEAR: 1997 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0033-2917 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Psychol Med |
| COUNTRY: England |
| ISSNLINKING: 0033-2917 |
| NLMUNIQUEID: 1254142 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Alcoholism |
genetics |
| Australia |
epidemiology |
| Catholicism |
epidemiology |
| Diseases in Twins |
genetics |
| Female |
genetics |
| Humans |
genetics |
| Logistic Models |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Models, Genetic |
genetics |
| Odds Ratio |
genetics |
| Personality |
classification |
| Prevalence |
classification |
| Registries |
classification |
| Risk Factors |
classification |
| Severity of Illness Index |
classification |
| Sex Factors |
classification |
| Twins, Dizygotic |
classification |
| Twins, Monozygotic |
classification |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
