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PMID |
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TITLE |
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A twin-pronged attack on complex traits. |
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ABSTRACT |
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Before one starts the hunt for quantitative trait loci (QTLs) for a complex trait, it is necessary to show that the trait is genetically influenced. This evidence is most likely to come from the classical twin study--the demonstration that monozygotic twins are more similar for the trait than dizygotic twins. The strengths and weaknesses of twin studies are discussed, and it is suggested that, far from becoming irrelevant with advances in molecular biology, they can improve the efficiency of QTL detection and play an important role in unravelling developmental genetic mechanisms. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
pubmed |
1997/12/17 |
medline |
1997/12/17 00:01 |
entrez |
1997/12/17 00:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Martin N |
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Martin |
N |
N |
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Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia. nickM@qimr.edu.au |
Boomsma D |
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Boomsma |
D |
D |
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Machin G |
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Machin |
G |
G |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 17 |
ISSUE: 4 |
TITLE: Nature genetics |
ISOABBREVIATION: Nat. Genet. |
YEAR: 1997 |
MONTH: Dec |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 1061-4036 |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Genet |
COUNTRY: United States |
ISSNLINKING: 1061-4036 |
NLMUNIQUEID: 9216904 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Review |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Diseases in Twins |
genetics |
Genetic Linkage |
genetics |
Genetic Markers |
genetics |
Humans |
genetics |
Models, Genetic |
genetics |
Multivariate Analysis |
genetics |
Quantitative Trait, Heritable |
genetics |
Social Environment |
genetics |
Twins, Dizygotic |
genetics |
Twins, Monozygotic |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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REGISTRYNUMBER |
NAMEOFSUBSTANCE |
0 |
Genetic Markers |
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OTHER ID's |
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