|
|
| PMID |
|
|
| TITLE |
|
| Association of a low density lipoprotein receptor microsatellite variant with obesity. |
|
| ABSTRACT |
|
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. |
| DESIGN |
NlmCategory: METHODS |
| A cross-sectional case-control study. |
| SUBJECTS |
NlmCategory: METHODS |
| One hundred and seven obese individuals, defined as a body mass index (BMI) > or = 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2. |
| MEASUREMENTS |
NlmCategory: METHODS |
| BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). |
| RESULTS |
NlmCategory: RESULTS |
| There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (chi 2 = 12.3, P = 0.002), but not in males (chi 2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| These results suggest that in females, LDLR may play a role in the development of obesity. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1997/11/22 |
| medline |
1997/11/22 00:01 |
| entrez |
1997/11/22 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Rutherford S |
|
Rutherford |
S |
S |
|
Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Australia. |
| Nyholt DR |
|
Nyholt |
D R |
DR |
|
|
| Curtain RP |
|
Curtain |
R P |
RP |
|
|
| Quinlan SR |
|
Quinlan |
S R |
SR |
|
|
| Gaffney PT |
|
Gaffney |
P T |
PT |
|
|
| Morris BJ |
|
Morris |
B J |
BJ |
|
|
| Griffiths LR |
|
Griffiths |
L R |
LR |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 21 |
| ISSUE: 11 |
| TITLE: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity |
| ISOABBREVIATION: Int. J. Obes. Relat. Metab. Disord. |
| YEAR: 1997 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: |
| ISSNTYPE: |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Int J Obes Relat Metab Disord |
| COUNTRY: ENGLAND |
| ISSNLINKING: |
| NLMUNIQUEID: 9313169 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Comparative Study |
| Journal Article |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Alleles |
|
| Analysis of Variance |
|
| Body Mass Index |
|
| Case-Control Studies |
|
| Cross-Sectional Studies |
|
| Female |
|
| Genotype |
|
| Humans |
|
| Hypertension |
genetics |
| Lipids |
blood |
| Male |
blood |
| Microsatellite Repeats |
genetics |
| Obesity |
genetics |
| Polymorphism, Genetic |
genetics |
| Receptors, LDL |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Lipids |
| 0 |
Receptors, LDL |
|
| OTHER ID's |
|
|
|
