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| PMID |
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| TITLE |
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| Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. |
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| ABSTRACT |
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| The association between MSHR coding region variation and hair colour in humans has been examined by genotyping 25 red haired and 62 non-red Caucasians, all of whom were 12 years of age and members of a twin pair study. Twelve amino acid substitutions were seen at 11 different sites, nine of these being newly described MSHR variants. The previously reported Val92Met allele shows no association with hair colour, but the three alleles Arg151Cys, Arg160Trp and Asp294His were associated with red hair and one Val60Leu variant was most frequent in fair/blonde and light brown hair colours. Variant MSHR genotypes are associated with lighter skin types and red hair (P < 0.001). However, comparison of the MSHR genotypes in dizygotic twin pairs discordant for red hair colour indicates that the MSHR gene cannot be solely responsible for the red hair phenotype, since five of 13 pairs tested had both haplotypes identical by state (with three of the five having both identical by descent). Rather, it is likely that additional modifier genes exist, making variance in the MSHR gene necessary but not always sufficient, for red hair production. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1997/09/25 |
| medline |
1997/09/25 00:01 |
| entrez |
1997/09/25 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Box NF |
|
Box |
N F |
NF |
|
Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia. |
| Wyeth JR |
|
Wyeth |
J R |
JR |
|
|
| O'Gorman LE |
|
O'Gorman |
L E |
LE |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
| Sturm RA |
|
Sturm |
R A |
RA |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 6 |
| ISSUE: 11 |
| TITLE: Human molecular genetics |
| ISOABBREVIATION: Hum. Mol. Genet. |
| YEAR: 1997 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0964-6906 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Hum Mol Genet |
| COUNTRY: England |
| ISSNLINKING: 0964-6906 |
| NLMUNIQUEID: 9208958 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Alleles |
|
| Amino Acid Sequence |
|
| Asian Continental Ancestry Group |
genetics |
| Child |
genetics |
| Cloning, Molecular |
genetics |
| European Continental Ancestry Group |
genetics |
| Female |
genetics |
| Gene Frequency |
genetics |
| Genetic Variation |
genetics |
| Hair Color |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Molecular Sequence Data |
genetics |
| Receptors, Pituitary Hormone |
genetics |
| Skin Pigmentation |
genetics |
| Twins |
genetics |
| Twins, Dizygotic |
genetics |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
MSH receptor |
| 0 |
Receptors, Pituitary Hormone |
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| OTHER ID's |
|
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|
