Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
9293047
TITLE
Nicotine withdrawal in women.
ABSTRACT
Associations between self-report symptom profiles for nicotine withdrawal, personality (TPQ, EPQ-R), life-time history of psychopathology and smoking history were examined in data obtained from 553 female adult Australian twins (246 regular smokers), aged 32-48 years, who had participated in a telephone interview survey that included life-time assessments of smoking history, nicotine dependence and symptoms of withdrawal. Two hundred and two respondents were from high-risk pairs where either the respondent or the respondent's co-twin had reported a life-time history of alcohol dependence; 351 were from control pairs. Latent class analysis was used to identify subtypes ('classes') of smokers reporting similar withdrawal symptom profiles. Three major classes were identified which appeared to represent a continuum from mild to severe nicotine withdrawal. Smokers from the severe withdrawal class were best characterized by hands shaking and by the prominence of depressive features. There were marked increases in life-time alcohol dependence rates as a function of severity class. In contrast, significantly elevated rates of major depression, conduct disorder and anxiety disorder were observed only among smokers from the most severe withdrawal class. Neuroticism was the only personality factor strongly associated with the development of withdrawal symptoms.
DATE PUBLISHED
1997 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1997/07/01 00:00
medline 1997/09/18 00:01
entrez 1997/07/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Madden PA Madden P A PA Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Bucholz KK Bucholz K K KK
Dinwiddie SH Dinwiddie S H SH
Slutske WS Slutske W S WS
Bierut LJ Bierut L J LJ
Statham DJ Statham D J DJ
Dunne MP Dunne M P MP
Martin NG Martin N G NG
Heath AC Heath A C AC
INVESTIGATORS
JOURNAL
VOLUME: 92
ISSUE: 7
TITLE: Addiction (Abingdon, England)
ISOABBREVIATION: Addiction
YEAR: 1997
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0965-2140
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Addiction
COUNTRY: England
ISSNLINKING: 0965-2140
NLMUNIQUEID: 9304118
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
DA00272 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Diseases in Twins
Female
Humans
Mental Disorders chemically induced
Middle Aged chemically induced
Nicotine adverse effects
Personality adverse effects
Smoking adverse effects
Substance Withdrawal Syndrome psychology
Tobacco Use Disorder complications
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
54-11-5 Nicotine
OTHER ID's