|
|
| PMID |
|
|
| TITLE |
|
| Modeling genetic and environmental influences in the etiology of conduct disorder: a study of 2,682 adult twin pairs. |
|
| ABSTRACT |
|
|
|
| The etiology of conduct disorder (CD) was examined retrospectively in a sample of 2,682 male, female, and unlike-sex adult twin pairs from the community-based Australian Twin Register. Model-fitting analyses indicated a substantial genetic influence on risk for CD, accounting for 71% of the variance (95% confidence interval [CI] = 32-79%). There was not a statistically significant effect of the shared environment in the best-fitting model of CD, but a modest effect of the shared environment on the risk for CD could not be rejected (95% CI = 0-32%). The magnitude of genetic and environmental influences for CD liability did not vary significantly for boys and girls, and the specific genetic and environmental mechanisms important for the development of CD appeared to be largely the same for both sexes. The fit of a multiple-threshold model raises the possibility that CD may not necessarily be a discrete entity but rather an extreme of the normal variation in conduct-disordered behavior found in the general population. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1997/05/01 |
| medline |
1997/05/01 00:01 |
| entrez |
1997/05/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Slutske WS |
|
Slutske |
W S |
WS |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110-1093, USA. wendy@wupsych1.wuStL.edu |
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Dinwiddie SH |
|
Dinwiddie |
S H |
SH |
|
|
| Madden PA |
|
Madden |
P A |
PA |
|
|
| Bucholz KK |
|
Bucholz |
K K |
KK |
|
|
| Dunne MP |
|
Dunne |
M P |
MP |
|
|
| Statham DJ |
|
Statham |
D J |
DJ |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 106 |
| ISSUE: 2 |
| TITLE: Journal of abnormal psychology |
| ISOABBREVIATION: J Abnorm Psychol |
| YEAR: 1997 |
| MONTH: May |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0021-843X |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Abnorm Psychol |
| COUNTRY: United States |
| ISSNLINKING: 0021-843X |
| NLMUNIQUEID: 0034461 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| MH17104 |
NIMH NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Antisocial Personality Disorder |
psychology |
| Child |
psychology |
| Child Behavior Disorders |
psychology |
| Diseases in Twins |
psychology |
| Female |
psychology |
| Humans |
psychology |
| Male |
psychology |
| Middle Aged |
psychology |
| Models, Genetic |
psychology |
| Retrospective Studies |
psychology |
| Sex Factors |
psychology |
| Social Environment |
psychology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
