Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
8933989
TITLE
Migraine association and linkage analyses of the human 5-hydroxytryptamine (5HT2A) receptor gene.
ABSTRACT
5-Hydroxytryptamine (5HT), commonly known as serotonin, which predominantly serves as an inhibitory neurotransmitter in the brain, has long been implicated in migraine pathophysiology. This study tested an MspI polymorphism in the human 5HT2A receptor gene (HTR2A) and a closely linked microsatellite marker (D13S126), for linkage and association with common migraine. In the association analyses, no significant differences were found between the migraine and control populations for both the MspI polymorphism and the D13S126 microsatellite marker. The linkage studies involving three families comprising 36 affected members were analysed using both parametric (FASTLINK) and non-parametric (MFLINK and APM) techniques. Significant close linkage was indicated between the MspI polymorphism and the D13S126 microsatellite marker at a recombination fraction (theta) of zero (lod score = 7.15). Linkage results for the MspI polymorphism were not very informative in the three families, producing maximum and minimum lod scores of only 0.35 and -0.39 at recombination fractions (theta) of 0.2 and 0.00, respectively. However, linkage analysis between the D13S126 marker and migraine indicated significant non-linkage (lod < -2) up to a recombination fraction (theta) of 0.028. Results from this study exclude the HTR2A gene, which has been localized to chromosome 13q14-q21, for involvement with common migraine.
DATE PUBLISHED
1996 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1996/11/01
medline 1996/11/01 00:01
entrez 1996/11/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Nyholt DR Nyholt D R DR School of Health Sciences, NHS, Griffith University, Gold Coast, Queensland, Australia.
Curtain RP Curtain R P RP
Gaffney PT Gaffney P T PT
Brimage P Brimage P P
Goadsby PJ Goadsby P J PJ
Griffiths LR Griffiths L R LR
INVESTIGATORS
JOURNAL
VOLUME: 16
ISSUE: 7
TITLE: Cephalalgia : an international journal of headache
ISOABBREVIATION: Cephalalgia
YEAR: 1996
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0333-1024
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Cephalalgia
COUNTRY: England
ISSNLINKING: 0333-1024
NLMUNIQUEID: 8200710
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alleles
Chromosomes, Human, Pair 13
Female
Genetic Linkage
Humans
Male
Microsatellite Repeats
Migraine Disorders metabolism
Pedigree metabolism
Polymerase Chain Reaction metabolism
Polymorphism, Genetic metabolism
Receptors, Serotonin genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Receptors, Serotonin
OTHER ID's