Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
8465673
TITLE
Genetic models for the natural history of smoking: evidence for a genetic influence on smoking persistence.
ABSTRACT
We reanalyze data from the 1981 mailed questionnaire survey of the Australian twin register, to test for a genetic effect on smoking persistence (whether or not a smoker quits smoking). In the young cohort, aged 18-30 years, there are too few ex-smokers to permit resolution of genetic and non-genetic models. In the older cohort, we find a significant and substantial genetic effect on smoking persistence, accounting for 53% of the variance. This genetic effect on smoking persistence is independent of genetic effects on smoking initiation.
DATE PUBLISHED
1993 Jan-Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1993/01/01
medline 1993/01/01 00:01
entrez 1993/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Heath AC Heath A C AC Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 1
TITLE: Addictive behaviors
ISOABBREVIATION: Addict Behav
YEAR:
MONTH:
DAY:
MEDLINEDATE: 1993 Jan-Feb
SEASON:
CITEDMEDIUM: Print
ISSN: 0306-4603
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Addict Behav
COUNTRY: ENGLAND
ISSNLINKING: 0306-4603
NLMUNIQUEID: 7603486
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Age Factors
Behavior, Addictive
Cohort Studies
Female
Humans
Male
Models, Genetic
Smoking genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's