|
|
| PMID |
|
|
| TITLE |
|
| Psoriasis in Australian twins. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Occurrence of psoriasis has been found to be strongly genetically controlled in Northern European and U.S. twin and family studies. |
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| Our purpose was to assess cumulative incidence and heritability of psoriasis in the Australian population. |
| METHODS |
NlmCategory: METHODS |
| Australian twins reporting psoriasis on a screening questionnaire received from 3808 pairs were mailed a detailed instrument designed to validate the diagnosis, supplemented by telephone interview and examination of medical records. |
| RESULTS |
NlmCategory: RESULTS |
| Only 94 of 160 subjects who screened positive were confirmed to have psoriasis. The cumulative incidence of confirmed psoriasis was 2% in 30- to 60-year-old subjects. The monozygotic twin casewise concordance for confirmed psoriasis was 35% (12 of 34 pairs), and the dizygotic twin concordance 12% (5 of 43 pairs), giving an estimated heritability of 80%, was similar to that found in a genetic reanalysis of three previous twin studies. A case-control analysis of psoriasis-discordant twin pairs found no evidence for influences of alcohol or coffee intake, overweight, birth weight, or personality in the origin of psoriasis. |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| Occurrence of psoriasis in the Australian population is highly heritable, but identical twins are often discordant; the factor responsible for the onset of disease in one twin and not the other is unclear. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1993/09/01 |
| medline |
1993/09/01 00:01 |
| entrez |
1993/09/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Duffy DL |
|
Duffy |
D L |
DL |
|
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia. |
| Spelman LS |
|
Spelman |
L S |
LS |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 29 |
| ISSUE: 3 |
| TITLE: Journal of the American Academy of Dermatology |
| ISOABBREVIATION: J. Am. Acad. Dermatol. |
| YEAR: 1993 |
| MONTH: Sep |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0190-9622 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Am Acad Dermatol |
| COUNTRY: United States |
| ISSNLINKING: 0190-9622 |
| NLMUNIQUEID: 7907132 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Australia |
epidemiology |
| Case-Control Studies |
epidemiology |
| Diseases in Twins |
epidemiology |
| Female |
epidemiology |
| Follow-Up Studies |
epidemiology |
| Humans |
epidemiology |
| Male |
epidemiology |
| Middle Aged |
epidemiology |
| Observer Variation |
epidemiology |
| Psoriasis |
epidemiology |
| Questionnaires |
epidemiology |
| Twins, Dizygotic |
epidemiology |
| Twins, Monozygotic |
epidemiology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
