|
|
| PMID |
|
|
| TITLE |
|
| Panic disorder in women: a population-based twin study. |
|
| ABSTRACT |
|
|
|
| Previous studies based on probands from clinical samples suggest that panic disorder aggregates strongly in families and may be due to a highly penetrant single major locus. In this study we examine panic disorder as assessed at blind, structured psychiatric interview in 2163 women from a population-based twin registry. DSM-III-R diagnoses were assigned at a narrow and at a broad level both by clinician review and by computer algorithm. The familial aggregation of panic disorder in this sample was only modest. The relatively small number of affected individuals prevented a definitive resolution of competing genetic and non-genetic models of familial transmission. Although there was some inconsistency across diagnostic approaches, most results suggested that the familial aggregation of panic disorder was due largely to genetic factors. Using a multifactorial-threshold model, the best estimates of the heritability of liability ranged from 30 to 40%. From a familial perspective, panic disorder with phobic avoidance appears to represent a more severe form of the syndrome than panic disorder without avoidance. Our results, which suggest that in the general population panic disorder is only a moderately heritable condition, are at variance with results from several previous investigations based on clinically ascertained samples. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1993/05/01 |
| medline |
1993/05/01 00:01 |
| entrez |
1993/05/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Kendler KS |
|
Kendler |
K S |
KS |
|
Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0710. |
| Neale MC |
|
Neale |
M C |
MC |
|
|
| Kessler RC |
|
Kessler |
R C |
RC |
|
|
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Eaves LJ |
|
Eaves |
L J |
LJ |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 23 |
| ISSUE: 2 |
| TITLE: Psychological medicine |
| ISOABBREVIATION: Psychol Med |
| YEAR: 1993 |
| MONTH: May |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0033-2917 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Psychol Med |
| COUNTRY: England |
| ISSNLINKING: 0033-2917 |
| NLMUNIQUEID: 1254142 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, U.S. Gov't, P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| CommentIn |
Psychol Med. 1994 Feb;24(1):259-60 |
8208890 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| HD-26746 |
NICHD NIH HHS |
United States |
| MH-40828 |
NIMH NIH HHS |
United States |
| NS-25630 |
NINDS NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Diseases in Twins |
psychology |
| Female |
psychology |
| Humans |
psychology |
| Models, Genetic |
psychology |
| Panic Disorder |
psychology |
| Psychiatric Status Rating Scales |
psychology |
| Risk Factors |
psychology |
| Social Environment |
psychology |
| Twins, Dizygotic |
psychology |
| Twins, Monozygotic |
psychology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
|
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|
