| PMID |
|
|
| TITLE |
|
| Probability of gene identity by descent: computation and applications. |
|
| ABSTRACT |
|
|
|
| Two genes at a given locus are identical by descent (IBD) if both have been inherited from a common ancestor. We present an algorithm for computing the probabilities of all IBD relationships among the genes of pedigree members. We show how to use these probabilities to calculate the probability of any combination of genotypes or phenotypes for the pedigree members. Applications to linkage analysis and genetic counseling are illustrated with examples. The algorithm also can be used to calculate the generalized kinship coefficients proposed by others. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1994/03/01 |
| medline |
1994/03/01 00:01 |
| entrez |
1994/03/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Whittemore AS |
|
Whittemore |
A S |
AS |
|
Department of Health Research and Policy, Stanford University School of Medicine, California 94305. |
| Halpern J |
|
Halpern |
J |
J |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 50 |
| ISSUE: 1 |
| TITLE: Biometrics |
| ISOABBREVIATION: Biometrics |
| YEAR: 1994 |
| MONTH: Mar |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0006-341X |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Biometrics |
| COUNTRY: United States |
| ISSNLINKING: 0006-341X |
| NLMUNIQUEID: 0370625 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, U.S. Gov't, P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| CA 47448 |
NCI NIH HHS |
United States |
| GM 21215 |
NIGMS NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Algorithms |
|
| Biometry |
methods |
| Female |
methods |
| Genetic Counseling |
methods |
| Genetic Linkage |
methods |
| Genotype |
methods |
| Humans |
methods |
| Male |
methods |
| Models, Genetic |
methods |
| Pedigree |
methods |
| Phenotype |
methods |
| Probability |
methods |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
