| PMID |
|
|
| TITLE |
|
| Quantitative trait locus for reading disability on chromosome 6. |
|
| ABSTRACT |
|
|
|
| Interval mapping of data from two independent samples of sib pairs, at least one member of whom was reading disabled, revealed evidence for a quantitative trait locus (QTL) on chromosome 6. Results obtained from analyses of reading performance from 114 sib pairs genotyped for DNA markers localized the QTL to 6p21.3. Analyses of corresponding data from an independent sample of 50 dizygotic twin pairs provided evidence for linkage to the same region. In combination, the replicate samples yielded a chi 2 value of 16.73 (P = 0.0002). Examination of twin and kindred siblings with more extreme deficits in reading performance yielded even stronger evidence for a QTL (chi 2 = 27.35, P < 0.00001). The position of the QTL was narrowly defined with a 100:1 confidence interval to a 2-centimorgan region within the human leukocyte antigen complex. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1994/10/14 |
| medline |
1994/10/14 00:01 |
| entrez |
1994/10/14 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Cardon LR |
|
Cardon |
L R |
LR |
|
Health Sciences Program, SRI International, Menlo Park, CA 94025. |
| Smith SD |
|
Smith |
S D |
SD |
|
|
| Fulker DW |
|
Fulker |
D W |
DW |
|
|
| Kimberling WJ |
|
Kimberling |
W J |
WJ |
|
|
| Pennington BF |
|
Pennington |
B F |
BF |
|
|
| DeFries JC |
|
DeFries |
J C |
JC |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 266 |
| ISSUE: 5183 |
| TITLE: Science (New York, N.Y.) |
| ISOABBREVIATION: Science |
| YEAR: 1994 |
| MONTH: Oct |
| DAY: 14 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0036-8075 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Science |
| COUNTRY: United States |
| ISSNLINKING: 0036-8075 |
| NLMUNIQUEID: 0404511 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| CommentIn |
Science. 1995 May 12;268(5212):786-8 |
7605493 |
|
| ErratumIn |
Science. 1995 Jun 16;268(5217):1553 |
7777847 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| HD-11681 |
NICHD NIH HHS |
United States |
| HD-27802 |
NICHD NIH HHS |
United States |
| HG-00085 |
NHGRI NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Alleles |
|
| Child |
|
| Chromosome Mapping |
|
| Chromosomes, Human, Pair 6 |
|
| Diseases in Twins |
genetics |
| Dyslexia |
genetics |
| Female |
genetics |
| Genetic Linkage |
genetics |
| Genetic Markers |
genetics |
| HLA Antigens |
genetics |
| Humans |
genetics |
| Major Histocompatibility Complex |
genetics |
| Male |
genetics |
| Nuclear Family |
genetics |
| Regression Analysis |
genetics |
| Twins, Dizygotic |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Genetic Markers |
| 0 |
HLA Antigens |
|
| OTHER ID's |
|
|
