|
|
| PMID |
|
|
| TITLE |
|
| Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. |
|
| ABSTRACT |
|
|
|
| Genetic studies are under way for many complex traits, spurred by the recent feasibility of whole genome scans. Clear guidelines for the interpretation of linkage results are needed to avoid a flood of false positive claims. At the same time, an overly cautious approach runs the risk of causing true hints of linkage to be missed. We address this problem by proposing specific standards designed to maintain rigor while also promoting communication. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1995/11/01 |
| medline |
1995/11/01 00:01 |
| entrez |
1995/11/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Lander E |
|
Lander |
E |
E |
|
Whitehead Institute for Biomedical Research, Cambridge Massachusetts 02142, USA. |
| Kruglyak L |
|
Kruglyak |
L |
L |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 11 |
| ISSUE: 3 |
| TITLE: Nature genetics |
| ISOABBREVIATION: Nat. Genet. |
| YEAR: 1995 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1061-4036 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Nat Genet |
| COUNTRY: United States |
| ISSNLINKING: 1061-4036 |
| NLMUNIQUEID: 9216904 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, U.S. Gov't, P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| CommentIn |
Nat Genet. 1995 Nov;11(3):223-4 |
7581436 |
|
| CommentIn |
Nat Genet. 1996 Oct;14(2):132-3 |
8841180 |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Genetic Linkage |
|
| Genetics |
standards |
| Genome |
standards |
| Lod Score |
standards |
| Models, Genetic |
standards |
| Research Design |
standards |
| Statistics as Topic |
standards |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
