Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
7201774
TITLE
Evidence for directional non-additivity in the genetics of finger ridge counts.
ABSTRACT
A genetical analysis of variation in finger ridge counts of 221 pairs of twins and 80 pairs of opposite sex siblings has been carried out. Negative regression of DZ and sibling pair variances on pair means suggests the action of non-additive genes or unequal gene frequencies tending to increase finger ridge counts. Negative skewness of the distributions supports this view. While models including dominance or epistasis are not a significant improvement over purely additive genetic models, it is regarded as important that large and positive values of non-additive genetic variance are estimated. The evolutionary importance of dominance and epistasis for greater finger ridge counts is discussed.
DATE PUBLISHED
1982 May-Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1982/05/01
medline 1982/05/01 00:01
entrez 1982/05/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Martin NG Martin N G NG
Loesch DZ Loesch D Z DZ
Jardine R Jardine R R
INVESTIGATORS
JOURNAL
VOLUME: 9
ISSUE: 3
TITLE: Annals of human biology
ISOABBREVIATION: Ann. Hum. Biol.
YEAR:
MONTH:
DAY:
MEDLINEDATE: 1982 May-Jun
SEASON:
CITEDMEDIUM: Print
ISSN: 0301-4460
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Ann Hum Biol
COUNTRY: England
ISSNLINKING: 0301-4460
NLMUNIQUEID: 0404024
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Dermatoglyphics
Female
Genetic Variation
Humans
Male
Mathematics
Models, Genetic
Pregnancy
Twins, Dizygotic
Twins, Monozygotic
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's