| PMID |
|
|
| TITLE |
|
| Directional dominance for low IgM and IgA levels. |
|
| ABSTRACT |
|
|
|
| A biometrical genetical analysis of IgG, IgM, and IgA levels in 134 sets of twins is reported. High heritabilities, around .8, are found for all three immunoglobulin levels, and possible reasons for lower heritabilities found in family studies are discussed. There is evidence for genetical dominance tending to decrease IgM and IgA levels, but there is no evidence for the importance of family environment although the presence of dominance may make its detection difficult. The causes of covariation in the three measurements are unclear in males but in females appear to be mainly environmental in correlations with IgA and equally genetical and environmental in the IgG-IgM correlation. |
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| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1981/09/01 |
| medline |
1981/09/01 00:01 |
| entrez |
1981/09/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Clark P |
|
Clark |
P |
P |
|
|
| Jardine R |
|
Jardine |
R |
R |
|
|
| Jones P |
|
Jones |
P |
P |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
| Walsh RJ |
|
Walsh |
R J |
RJ |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 33 |
| ISSUE: 5 |
| TITLE: American journal of human genetics |
| ISOABBREVIATION: Am. J. Hum. Genet. |
| YEAR: 1981 |
| MONTH: Sep |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0002-9297 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Am J Hum Genet |
| COUNTRY: United States |
| ISSNLINKING: 0002-9297 |
| NLMUNIQUEID: 0370475 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Clin Exp Immunol. 1968 Mar;3(3):233-44 |
4173142 |
|
| Cites |
J Immunol. 1969 Jun;102(6):1504-10 |
4182117 |
|
| Cites |
Clin Exp Immunol. 1969 Nov;5(5):469-77 |
4188215 |
|
| Cites |
Psychol Bull. 1970 May;73(5):311-49 |
5528333 |
|
| Cites |
Science. 1972 Apr 21;176(4032):311-2 |
5019789 |
|
| Cites |
Am J Hum Genet. 1974 Jan;26(1):1-12 |
4204534 |
|
| Cites |
Heredity (Edinb). 1976 Apr;36(2):205-14 |
1063734 |
|
| Cites |
Genetics. 1976 Aug;83(4):811-26 |
986976 |
|
| Cites |
Am J Hum Genet. 1977 Nov;29(6):571-4 |
930923 |
|
| Cites |
Heredity (Edinb). 1978 Feb;40(1):97-116 |
272366 |
|
| Cites |
Ann Hum Genet. 1975 Oct;39(2):219-29 |
1053249 |
|
| Cites |
Heredity (Edinb). 1978 Dec;41(3):249-320 |
370072 |
|
| Cites |
Hum Hered. 1979;29(5):306-9 |
573743 |
|
| Cites |
Clin Exp Immunol. 1980 Apr;40(1):8-15 |
6930337 |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Age Factors |
|
| Female |
|
| Genes, Dominant |
|
| Humans |
|
| Immunoglobulin A |
genetics |
| Immunoglobulin G |
genetics |
| Immunoglobulin M |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Models, Genetic |
genetics |
| Pregnancy |
genetics |
| Sex Factors |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Immunoglobulin A |
| 0 |
Immunoglobulin G |
| 0 |
Immunoglobulin M |
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| PMC1685124 |
NLM |
|
