| PMID |
|
|
| TITLE |
|
| Determinants of variation in plasma alkaline phosphatase activity: a twin study. |
|
| ABSTRACT |
|
|
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| Plasma alkaline phosphatase activity has been measured in 204 pairs of twins aged 18-34. Estimated genetic variance was the same in men and women, after exclusion of the youngest men, but environmental variance was greater in men so that the heritability was .90 +/- .02 in the women and .71 +/- .05 in the 19-34-year-old men. About 15% of the genetic variance was associated with the ABO blood group polymorphism, which is known to affect intestinal alkaline phosphatase. Differences in plasma alkaline phosphatase activity between normal people may be mainly due to genetically determined proportions of isoenzymes of differing stability. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1983/09/01 |
| medline |
1983/09/01 00:01 |
| entrez |
1983/09/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Whitfield JB |
|
Whitfield |
J B |
JB |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 35 |
| ISSUE: 5 |
| TITLE: American journal of human genetics |
| ISOABBREVIATION: Am. J. Hum. Genet. |
| YEAR: 1983 |
| MONTH: Sep |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0002-9297 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Am J Hum Genet |
| COUNTRY: United States |
| ISSNLINKING: 0002-9297 |
| NLMUNIQUEID: 0370475 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Clin Chem. 1965 Sep;11(9):876-88 |
5835656 |
|
| Cites |
Acta Genet Med Gemellol (Roma). 1970 Jan-Apr;19(1):122-6 |
4993637 |
|
| Cites |
Clin Chem. 1972 Dec;18(12):1468-74 |
4508937 |
|
| Cites |
Clin Chem. 1977;23(4):659-62 |
557378 |
|
| Cites |
Clin Chim Acta. 1977 Oct 1;80(1):209-20 |
908143 |
|
| Cites |
Clin Chem. 1978 Feb;24(2):212-22 |
627051 |
|
| Cites |
Clin Chem. 1978 Feb;24(2):313-20 |
627063 |
|
| Cites |
Heredity (Edinb). 1978 Dec;41(3):249-320 |
370072 |
|
| Cites |
Clin Chim Acta. 1980 Nov 20;108(1):81-7 |
7449139 |
|
| Cites |
Acta Genet Med Gemellol (Roma). 1980;29(3):171-92 |
7196668 |
|
| Cites |
Aust N Z J Med. 1981 Apr;11(2):140-3 |
6944037 |
|
| Cites |
Lancet. 1965 Mar 6;1(7384):530-1 |
14251523 |
|
| Cites |
J Pediatr. 1950 Mar;36(3):335-41 |
15405413 |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| ABO Blood-Group System |
genetics |
| Adolescent |
genetics |
| Adult |
genetics |
| Alkaline Phosphatase |
genetics |
| Environment |
genetics |
| Female |
genetics |
| Genetic Variation |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Models, Genetic |
genetics |
| Polymorphism, Genetic |
genetics |
| Pregnancy |
genetics |
| Twins |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
ABO Blood-Group System |
| EC 3.1.3.1 |
Alkaline Phosphatase |
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| PMC1685834 |
NLM |
|
