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| PMID |
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| TITLE |
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| Is Pi a selectively balanced polymorphism? |
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| ABSTRACT |
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| A stable polymorphism of the Pi alleles M1, M2 and M3 close to their observed frequencies has been predicted, simply by relating fitness to the proportion of each genotype having alpha 1-antitrypsin (alpha 1-AT) levels greater than 100 mg/100 ml. By further specifying that the rare S and Z genotypes with low alpha 1-AT levels have enhanced fertility, equilibria of the M, S and Z alleles have also been predicted close to their observed frequencies; however, none of these latter equilibria is stable, mainly because the predicted fitness of the SS genotype is too great. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1983/01/01 |
| medline |
1983/01/01 00:01 |
| entrez |
1983/01/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Martin NG |
|
Martin |
N G |
NG |
|
|
| Oakeshott JG |
|
Oakeshott |
J G |
JG |
|
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 33 |
| ISSUE: 1 |
| TITLE: Human heredity |
| ISOABBREVIATION: Hum. Hered. |
| YEAR: 1983 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0001-5652 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
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| MEDLINETA: Hum Hered |
| COUNTRY: Switzerland |
| ISSNLINKING: 0001-5652 |
| NLMUNIQUEID: 0200525 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Alleles |
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| Gene Frequency |
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| Genotype |
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| Humans |
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| Phenotype |
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| Polymorphism, Genetic |
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| Selection, Genetic |
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| alpha 1-Antitrypsin |
genetics |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
alpha 1-Antitrypsin |
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| OTHER ID's |
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|
