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| PMID |
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| TITLE |
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| Sense and nonsense in genetic epidemiology: a critique of the statistical model of Williams and Lyer. |
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| ABSTRACT |
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| The statistical model for the analysis of twin-family data of Williams and Iyer is examined. The model uses a large number of redundant parameters. It does not lead to quantitative predictions for new relationships. It allows for epistasis but not dominance. It makes assumptions about assortative mating which are inconsistent with any biologically plausible mechanism. It assumes that the environmental correlation between parent and offspring is due to the direct effect of the parental genotypes, not phenotypes, on offspring environment. Other models which avoid these problems are more appropriate for the analysis of extended twin-family data. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1984/01/01 |
| medline |
1984/01/01 00:01 |
| entrez |
1984/01/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
| Eaves LJ |
|
Eaves |
L J |
LJ |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
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| VOLUME: 33 |
| ISSUE: 4 |
| TITLE: Acta geneticae medicae et gemellologiae |
| ISOABBREVIATION: Acta Genet Med Gemellol (Roma) |
| YEAR: 1984 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0001-5660 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Acta Genet Med Gemellol (Roma) |
| COUNTRY: Italy |
| ISSNLINKING: 0001-5660 |
| NLMUNIQUEID: 0370314 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, U.S. Gov't, P.H.S. |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| GM30250 |
NIGMS NIH HHS |
United States |
| HL28922 |
NHLBI NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Analysis of Variance |
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| Environment |
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| Epistasis, Genetic |
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| Female |
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| Gene Expression Regulation |
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| Genotype |
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| Humans |
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| Male |
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| Models, Genetic |
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| Pedigree |
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| Phenotype |
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| Pregnancy |
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| Twins |
|
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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