| PMID |
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| TITLE |
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| Evidence for polygenic epistatic interactions in man? |
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| ABSTRACT |
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| Studies of multifactorial inheritance in man have ignored nonadditive gene action or attributed it entirely to dominance. Reanalyses of dermatoglyphic data on monozygotic and dizygotic twins, siblings and parents and offspring suggest that a substantial proportion of variation in total finger pattern intensity is due to epistatic interactions between additive genetic deviations, not dominance. Bootstrapping and power simulations support this interpretation of the data. We believe this is the strongest evidence so far for polygenic epistasis in man. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1984/04/01 |
| medline |
1984/04/01 00:01 |
| entrez |
1984/04/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
| Eaves LJ |
|
Eaves |
L J |
LJ |
|
|
| Loesch D |
|
Loesch |
D |
D |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
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| VOLUME: 106 |
| ISSUE: 4 |
| TITLE: Genetics |
| ISOABBREVIATION: Genetics |
| YEAR: 1984 |
| MONTH: Apr |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0016-6731 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Genetics |
| COUNTRY: United States |
| ISSNLINKING: 0016-6731 |
| NLMUNIQUEID: 0374636 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
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| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Psychol Bull. 1970 May;73(5):311-49 |
5528333 |
|
| Cites |
Heredity (Edinb). 1975 Feb;34(1):132-6 |
1054674 |
|
| Cites |
Am J Hum Genet. 1976 May;28(3):228-42 |
944529 |
|
| Cites |
Behav Genet. 1977 Mar;7(2):147-59 |
869856 |
|
| Cites |
Am J Hum Genet. 1979 Mar;31(2):176-98 |
453202 |
|
| Cites |
Genet Res. 1979 Apr;33(2):175-88 |
478296 |
|
| Cites |
Genet Res. 1982 Apr;39(2):187-98 |
7084667 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| GM30250 |
NIGMS NIH HHS |
United States |
| HL28922 |
NHLBI NIH HHS |
United States |
|
| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Dermatoglyphics |
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| Epistasis, Genetic |
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| Female |
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| Humans |
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| Models, Biological |
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| Pregnancy |
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| Twins |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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| OTHERID |
SOURCE |
| PMC1202301 |
NLM |
|
