| PMID |
|
|
| TITLE |
|
| A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes. |
|
| ABSTRACT |
|
|
|
| Two widely used affected-sib-pair scoring procedures (the Green and Woodrow [1977] procedure, and the method of forming all possible affected-sib-pairs) are compared with a new method for their relative efficiency in detecting the presence of an HLA-linked disease susceptibility gene. Their relative performance is investigated by extensive computer simulations over a large number of disease transmission models. On the average, the new procedure appears to outperform the Green and Woodrow method and the "all-possible-pairs" method. |
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| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1984/05/01 |
| medline |
1984/05/01 00:01 |
| entrez |
1984/05/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Suarez BK |
|
Suarez |
B K |
BK |
|
|
| Van Eerdewegh P |
|
Van Eerdewegh |
P |
P |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 18 |
| ISSUE: 1 |
| TITLE: American journal of medical genetics |
| ISOABBREVIATION: Am. J. Med. Genet. |
| YEAR: 1984 |
| MONTH: May |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0148-7299 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Am J Med Genet |
| COUNTRY: United States |
| ISSNLINKING: 0148-7299 |
| NLMUNIQUEID: 7708900 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Comparative Study |
| Journal Article |
| Research Support, U.S. Gov't, P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| GM 28719 |
NIGMS NIH HHS |
United States |
| MH 14677 |
NIMH NIH HHS |
United States |
| MH 31302 |
NIMH NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Computers |
|
| Disease Susceptibility |
|
| Genes, MHC Class II |
|
| Genetic Linkage |
|
| HLA-DQ Antigens |
|
| Histocompatibility Antigens Class II |
genetics |
| Humans |
genetics |
| Models, Genetic |
genetics |
| Pedigree |
genetics |
| Phenotype |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
HLA-DQ Antigens |
| 0 |
Histocompatibility Antigens Class II |
|
| OTHER ID's |
|
|
